EP 1077958 A1 20010228 - OXAZOLE-ARYL-CARBOXYLIC ACIDS USEFUL IN THE TREATMENT OF INSULIN RESISTANCE AND HYPERGLYCEMIA
Title (en)
OXAZOLE-ARYL-CARBOXYLIC ACIDS USEFUL IN THE TREATMENT OF INSULIN RESISTANCE AND HYPERGLYCEMIA
Title (de)
OXAZOLE-ARYLCARBONSÄURE DERIVATE FÜR DIE BEHANDLUNG VON INSULINRESISTENZ UND HYPERGLYKÄMIE
Title (fr)
ACIDES OXAZOL-ARYL-CARBOXYLIQUES UTILES DANS LE TRAITEMENT DE L'INSULINORESISTANCE ET DE L'HYPERGLYCEMIE
Publication
Application
Priority
- US 9910183 W 19990510
- US 7671098 A 19980512
Abstract (en)
[origin: WO9958511A1] This invention provides compounds of Formula (I) having the structure (I) wherein R is (a) or (b); A is OR<5>, or (c); R<1> is alkyl of 1-6 carbon atoms, cycloalkyl of 3-8 carbon atoms, thienyl, furyl, pyridyl, (d) or (e) R<2> is hydrogen, alkyl of 1-6 carbons atoms, or aryl of 6 to 10 carbon atoms; R<3> and R<4> are independently halogen, hydrogen, alkyl of 1-12 carbon atoms, aryl of 6 to 10 carbon atoms; halogen, trifluoromethyl of 1-6 carbon atoms, alkoxyaryl of 7-14 carbon atoms; nitro, amino, carboalkoxy, carbamide, carbamate, urea, alkylsulfoamide, -NR<7>(CH2)mO2H, arylsulfoamide, cycloalkyl of 3-8 carbon atoms, or heterocycle of 5 to 7 atom rings containing from 1 to 3 heteroatoms selected from oxygen, nitrogen, or sulfur; R<5> is hydrogen, alkyl of 1-6 carbon atoms, -CH(R<8>)R<9>, -C(CH2)nCO2R<10>, -C(CH3)2CO2R<10>, -CH(R<8>)(CH2)nCO2R<10>, -CH(R<8>)C6H4CO2R<10>, or -CH2-tetrazole; R<6> is hydrogen, alkyl of 1-6 carbon atoms, halogen, alkyoxy of 1-6 carbon atoms, trifluoroalkyl of 1-6 carbon atoms or trifluoroalkoxy of 1-6 carbon atoms; or a pharmaceutically acceptable salt thereof, which are useful in treating metabolic disorders related to insulin resistance or hyperglycemia.
IPC 1-7
C07D 263/32; C07D 413/10; C07D 413/12; C07D 277/24; C07D 417/12; A61K 31/42; A61K 31/425; C07D 413/04; C07D 417/04
IPC 8 full level
A61K 31/421 (2006.01); A61K 31/422 (2006.01); A61K 31/4245 (2006.01); A61K 31/426 (2006.01); A61K 31/4439 (2006.01); A61P 3/10 (2006.01); A61P 43/00 (2006.01); C07D 263/32 (2006.01); C07D 277/22 (2006.01); C07D 277/24 (2006.01); C07D 413/04 (2006.01); C07D 413/10 (2006.01); C07D 413/12 (2006.01); C07D 417/04 (2006.01); C07D 417/12 (2006.01)
CPC (source: EP)
A61P 3/10 (2017.12); A61P 43/00 (2017.12); C07D 263/32 (2013.01); C07D 277/24 (2013.01); C07D 413/10 (2013.01); C07D 413/12 (2013.01)
Citation (search report)
See references of WO 9958511A1
Designated contracting state (EPC)
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU NL PT SE
DOCDB simple family (publication)
WO 9958511 A1 19991118; AU 4073299 A 19991129; CA 2331118 A1 19991118; CN 1308618 A 20010815; EP 1077958 A1 20010228; JP 2002514631 A 20020521
DOCDB simple family (application)
US 9910183 W 19990510; AU 4073299 A 19990510; CA 2331118 A 19990510; CN 99808363 A 19990510; EP 99924163 A 19990510; JP 2000548315 A 19990510