Global patent index - EP 1077958 A1

EP 1077958 A1 2001-02-28 - OXAZOLE-ARYL-CARBOXYLIC ACIDS USEFUL IN THE TREATMENT OF INSULIN RESISTANCE AND HYPERGLYCEMIA

Title (en)

OXAZOLE-ARYL-CARBOXYLIC ACIDS USEFUL IN THE TREATMENT OF INSULIN RESISTANCE AND HYPERGLYCEMIA

Title (de)

OXAZOLE-ARYLCARBONSÄURE DERIVATE FÜR DIE BEHANDLUNG VON INSULINRESISTENZ UND HYPERGLYKÄMIE

Title (fr)

ACIDES OXAZOL-ARYL-CARBOXYLIQUES UTILES DANS LE TRAITEMENT DE L'INSULINORESISTANCE ET DE L'HYPERGLYCEMIE

Publication

EP 1077958 A1 (EN)

Application

EP 99924163 A

Priority

  • US 9910183 W
  • US 7671098 A

Abstract (en)

[origin: WO9958511A1] This invention provides compounds of Formula (I) having the structure (I) wherein R is (a) or (b); A is OR<5>, or (c); R<1> is alkyl of 1-6 carbon atoms, cycloalkyl of 3-8 carbon atoms, thienyl, furyl, pyridyl, (d) or (e) R<2> is hydrogen, alkyl of 1-6 carbons atoms, or aryl of 6 to 10 carbon atoms; R<3> and R<4> are independently halogen, hydrogen, alkyl of 1-12 carbon atoms, aryl of 6 to 10 carbon atoms; halogen, trifluoromethyl of 1-6 carbon atoms, alkoxyaryl of 7-14 carbon atoms; nitro, amino, carboalkoxy, carbamide, carbamate, urea, alkylsulfoamide, -NR<7>(CH2)mO2H, arylsulfoamide, cycloalkyl of 3-8 carbon atoms, or heterocycle of 5 to 7 atom rings containing from 1 to 3 heteroatoms selected from oxygen, nitrogen, or sulfur; R<5> is hydrogen, alkyl of 1-6 carbon atoms, -CH(R<8>)R<9>, -C(CH2)nCO2R<10>, -C(CH3)2CO2R<10>, -CH(R<8>)(CH2)nCO2R<10>, -CH(R<8>)C6H4CO2R<10>, or -CH2-tetrazole; R<6> is hydrogen, alkyl of 1-6 carbon atoms, halogen, alkyoxy of 1-6 carbon atoms, trifluoroalkyl of 1-6 carbon atoms or trifluoroalkoxy of 1-6 carbon atoms; or a pharmaceutically acceptable salt thereof, which are useful in treating metabolic disorders related to insulin resistance or hyperglycemia.

IPC 1-7 (main, further and additional classification)

C07D 263/32; A61K 31/42; A61K 31/425; C07D 277/24; C07D 413/04; C07D 413/10; C07D 413/12; C07D 417/04; C07D 417/12

IPC 8 full level (invention and additional information)

C07D 277/22 (2006.01); A61K 31/421 (2006.01); A61K 31/422 (2006.01); A61K 31/4245 (2006.01); A61K 31/426 (2006.01); A61K 31/4439 (2006.01); A61P 3/10 (2006.01); A61P 43/00 (2006.01); C07D 263/32 (2006.01); C07D 277/24 (2006.01); C07D 413/04 (2006.01); C07D 413/10 (2006.01); C07D 413/12 (2006.01); C07D 417/04 (2006.01); C07D 417/12 (2006.01)

CPC (invention and additional information)

C07D 413/12 (2013.01); C07D 263/32 (2013.01); C07D 277/24 (2013.01); C07D 413/10 (2013.01)

Citation (search report)

See references of WO 9958511A1

Designated contracting state (EPC)

AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU NL PT SE

EPO simple patent family

WO 9958511 A1 19991118; AU 4073299 A 19991129; CA 2331118 A1 19991118; CN 1308618 A 20010815; EP 1077958 A1 20010228; JP 2002514631 A 20020521

INPADOC legal status

2004-02-11 [18D] DEEMED TO BE WITHDRAWN

- Ref Legal Event Code: 18D

- Effective date: 20030807

2003-05-14 [17Q] FIRST EXAMINATION REPORT

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- Effective date: 20030327

2002-06-19 [RAP1] TRANSFER OF RIGHTS OF AN EP PUBLISHED APPLICATION

- Owner name: WYETH

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2001-02-28 [17P] REQUEST FOR EXAMINATION FILED

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- Effective date: 20001019

2001-02-28 [AK] DESIGNATED CONTRACTING STATES:

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- Designated State(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU NL PT SE

2001-02-28 [AX] REQUEST FOR EXTENSION OF THE EUROPEAN PATENT TO

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- Free Format Text: AL PAYMENT 20001019;LT PAYMENT 20001019;LV PAYMENT 20001019;RO PAYMENT 20001019;SI PAYMENT 20001019