EP 1077965 A1 20010228 - PHENYL OXO-ACETIC ACIDS USEFUL IN THE TREATMENT OF INSULIN RESISTANCE AND HYPERGLYCEMIA
Title (en)
PHENYL OXO-ACETIC ACIDS USEFUL IN THE TREATMENT OF INSULIN RESISTANCE AND HYPERGLYCEMIA
Title (de)
PHENYL-OXOESSIGSÄUREDERIVATE NÜTZLICH IN DER BEHANDLUNG VON INSULINRESISTENZ UND HYPERGLYCÄMIE
Title (fr)
ACIDES PHENYL-OXO-ACETIQUES UTILES DANS LE TRAITEMENT DE L'INSULINORESISTANCE ET DE L'HYPERGLYCEMIE
Publication
Application
Priority
- US 9910211 W 19990510
- US 7659698 A 19980512
Abstract (en)
[origin: WO9958519A1] This invention provides compounds of structural Formula (I) wherein A is O, S, or N; B is -(CH2)m-, -CH(OH)-, or carbonyl; R<1> is hydrogen, halogen, alkyl of 1-6 carbon atoms, alcoxy of 1-6 carbon atoms, or trifluoromethyl; R<2> is alkyl of 1-18 carbon atoms, aryl of 6-10 carbon atoms, arylalkyl of 7-15 carbon atoms, Het-alkyl wherein the alkyl moiety is 1-6 carbon atoms; Het is (a) or (b); R<2a> is alkylene of 1-3 carbon atoms; G is oxygen, sulfur, or nitrogen; R<3>, R<4> are each, independently, hydrogen, halogen, alkyl of 1-3 carbon atoms, aryl of 6-10 carbon atoms or a heterocyclic ring of 5 to 7 ring atom containing 1 to 3 heteroatoms selected from oxygen, nitrogen, sulfur; R<5> is hydrogen, alkyl of 1-6 carbon atoms, -CH(R<7>)R<8>, -C(CH2)nCO2R<9>, -C(CH3)2CO2R<9>, -CH(R<7>)(CH2)nCO2R<9>, or CH(R<7>)C6H4CO2R<9>; R<6> is hydrogen, halogen, alkyl of 1-6 carbon atoms, or -OR<5>; m=1-6; n=1-6; R<7> is hydrogen, alkyl of 1-6 carbons atoms, aryl of 6-10 carbon atoms, or arylalkyl of 7-15 carbon atoms; R<8> is -CO2R<10>, -CONHR<10>, tetrazole, or -PO3; R<9> and R<10> are each, independently, hydrogen, alkyl of 1-6 carbon atoms, aryl of 6-10 carbon atoms, or arylalkyl of 7-15 carbon atoms; or a pharmaceutically acceptable salt thereof, which are useful in treating metabolic disorders related to insulin resistance or hyperglycemia.
IPC 1-7
IPC 8 full level
A61K 31/343 (2006.01); A61K 31/381 (2006.01); A61P 3/10 (2006.01); C07D 307/80 (2006.01); C07D 333/56 (2006.01)
CPC (source: EP)
A61P 3/10 (2017.12); C07D 307/80 (2013.01); C07D 333/56 (2013.01)
Citation (search report)
See references of WO 9958519A1
Designated contracting state (EPC)
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU NL PT SE
DOCDB simple family (publication)
WO 9958519 A1 19991118; AU 3791799 A 19991129; CA 2331120 A1 19991118; CN 1308621 A 20010815; EP 1077965 A1 20010228; JP 2002514636 A 20020521
DOCDB simple family (application)
US 9910211 W 19990510; AU 3791799 A 19990510; CA 2331120 A 19990510; CN 99808361 A 19990510; EP 99920419 A 19990510; JP 2000548323 A 19990510