Global Patent Index - EP 1077970 A1

EP 1077970 A1 2001-02-28 - 11-ARYL-BENZO(B)NAPHTHO(2,3-D)FURANS AND 11-ARYL-BENZO(B)NAPHTHO(2,3-D)THIOPHENES USEFUL IN THE TREATMENT OF INSULIN RESISTANCE AND HYPERGLYCEMIA

Title (en)

11-ARYL-BENZO(B)NAPHTHO(2,3-D)FURANS AND 11-ARYL-BENZO(B)NAPHTHO(2,3-D)THIOPHENES USEFUL IN THE TREATMENT OF INSULIN RESISTANCE AND HYPERGLYCEMIA

Title (de)

11-ARYL-BENZO(B)NAPHTHO(2,3-D)FURAN- UND 11-ARYL-BENZO(B)NAPHTHO(2,3-D)THIOPHEN-DERIVATE VERWENDBAR ZUR BEHANDLUNG VON INSULINRESISTENZ UND HYPERGLYKAEMIE

Title (fr)

11-ARYL-BENZO B NAPHTO 2,3-D FURANES ET 11-ARYL-BENZO b NAPHTO 2,3-d THIOPHENES UTILES DANS LES TRAITEMENTS DE LA RESISTANCE INSULINIQUE ET DE L'HYPERGLYCEMIE

Publication

EP 1077970 A1 (EN)

Application

EP 99922897 A

Priority

  • US 9910185 W
  • US 7659298 A

Abstract (en)

[origin: WO9958521A1] The invention provides compounds of formula (I) having a structure wherein A is hydrogen, halogen, or OH; B and D are each, independently, hydrogen, halogen, CN, alkyl of 1-6 carbon atoms, aryl, aralkyl of 6-12 carbon atoms, nitro, amino or OR; R is hydrogen, alkyl of 1-6 carbon atoms, -COR<1>, -CH2CO2R<1>, -CH(R<1a>)CO2R<1>, or -SO2R<1>; R<1> and R<1a> are each, independently, hydrogen, alkyl of 1-6 carbon atoms, aralkyl of 6-12 carbon atoms or aryl; E is S, SO, SO2, O; X is hydrogen, halogen, alkyl of 1-6 carbon atoms, CN, perfluoroalkyl of 1-6 carbon atoms, alkoxy of 1-6 carbon atoms, aryloxy, arylalkoxy of 6-12 carbon atoms, nitro, amino, alkylsulfanyl of 1-6 carbon atoms, arylsulfanyl, pyridylsulfanyl, 2-N,N-dimethylaminoethylsulfanyl, or -OCH2CO2R<1b>; R<1b> is hydrogen or alkyl of 1-6 carbon atoms; Y and Z are each, independently, hydrogen or OR<2>; R<2> is hydrogen, alkyl of 1-6 carbon atoms, aralkyl of 6-12 carbon atoms, or -CH2CO2R<3>; R<3> is hydrogen or alkyl of 1-6 carbon atoms; C is hydrogen, halogen or OR<4>; R<4> is hydrogen, alkyl of 1-6 carbon atoms, -CH(R<5>)W, -C(CH3)2CO2R<6>, 5-thiazolidine-2,4-dione, -CH(R<7>)CH2CO2R<6>, -COR<6>, PO3(R<6>)2, or -SO2R<6>; R<5> is hydrogen, alkyl of 1-6 carbon atoms, aralkyl, aryl, CH2(1H-imidazol-4-yl), -CH2(3-1H-indolyl), -CH2CH2(1,3-dioxo-1,3-dihydro-isoindol-2-yl), -CH2CH2(1-oxo-1,3-dihydro-isoindol-2-yl), -CH2(3-pyridyl), or -CH2CO2H; W is -CO2R<6>, -CONH2, -CONHOH, CN, -CONH(CH2)2CN, 5-tetrazole, -PO3(R<6>)2, -CH2OH, or -CH2Br, -CONR<6>CHR<7>CO2R<8>, R<6> is hydrogen, alkyl of 1-6 carbon atoms, aryl or aralkyl; R<7> is hydrogen, alkyl of 1-6 carbon atoms, aryl or aralkyl; R<8> is hydrogen, alkyl of 1-6 carbon atoms, aryl or aralkyl; or a pharmaceutically acceptable salt thereof, which are useful in treating metabolic disorders related to insuling resistance or hyperglycemia.

IPC 1-7 (main, further and additional classification)

C07D 333/74; A61K 31/34; A61K 31/38; C07D 307/77; C07D 409/10

IPC 8 full level (invention and additional information)

C07D 333/50 (2006.01); A61K 31/343 (2006.01); A61K 31/381 (2006.01); A61K 31/4035 (2006.01); A61K 31/41 (2006.01); A61K 31/4178 (2006.01); A61K 31/427 (2006.01); A61K 31/4433 (2006.01); A61K 31/4436 (2006.01); A61K 31/665 (2006.01); A61K 31/67 (2006.01); A61P 3/10 (2006.01); C07D 307/77 (2006.01); C07D 333/74 (2006.01); C07D 409/10 (2006.01); C07D 409/12 (2006.01); C07D 417/12 (2006.01); C07F 9/655 (2006.01); C07F 9/6553 (2006.01)

CPC (invention and additional information)

C07D 307/77 (2013.01); C07D 333/74 (2013.01); C07D 409/10 (2013.01)

Citation (search report)

See references of WO 9958521A1

Designated contracting state (EPC)

AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU NL PT SE

Designated extension state (EPC)

AL LT LV RO SI

EPO simple patent family

WO 9958521 A1 19991118; AU 3979199 A 19991129; CA 2330623 A1 19991118; CN 1308627 A 20010815; EP 1077970 A1 20010228; JP 2002514638 A 20020521

INPADOC legal status


2003-08-20 [18D] DEEMED TO BE WITHDRAWN

- Effective date: 20030211

2002-06-19 [RAP1] TRANSFER OF RIGHTS OF AN EP PUBLISHED APPLICATION

- Owner name: WYETH

2001-08-29 [17Q] FIRST EXAMINATION REPORT

- Effective date: 20010717

2001-02-28 [17P] REQUEST FOR EXAMINATION FILED

- Effective date: 20001024

2001-02-28 [AK] DESIGNATED CONTRACTING STATES:

- Kind Code of Ref Document: A1

- Designated State(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU NL PT SE

2001-02-28 [AX] REQUEST FOR EXTENSION OF THE EUROPEAN PATENT TO

- Free text: AL PAYMENT 20001024;LT PAYMENT 20001024;LV PAYMENT 20001024;RO PAYMENT 20001024;SI PAYMENT 20001024