EP 1077971 A1 20010228 - 1,5-DIARYL SUBSTITUTED PYRAZOLES AS p38 KINASE INHIBITORS
Title (en)
1,5-DIARYL SUBSTITUTED PYRAZOLES AS p38 KINASE INHIBITORS
Title (de)
SUBSTITUIERTE 1,5-DIARYLPYRAZOLE ALS P38 KINASE INHIBITOREN
Title (fr)
PYRAZOLES A SUBSTITUTION 1,5-DIARYLE COMME INHIBITEURS DE LA PROTEINE p38 KINASE
Publication
Application
Priority
- US 9907036 W 19990512
- US 8549498 P 19980514
Abstract (en)
[origin: WO9958523A1] The present invention contemplates 1,5-diaryl-substituted pyrazole compounds which correspond in structure to Formula (I), or a pharmaceutically-acceptable salt thereof: wherein A is =N- or =CH-; and which inter alia, inhibit the activity of p38 MAP kinase. Also contemplated by the invention are processes for the preparation of the contemplated compounds and for the use of a contemplated compound in treating a mammalian host having a p38 kinase- or TNF-mediated disease.
IPC 1-7
C07D 401/04; C07D 401/14; C07D 403/04; A61K 31/44; A61K 31/505
IPC 8 full level
A61K 31/4427 (2006.01); A61K 31/4439 (2006.01); A61K 31/496 (2006.01); A61K 31/506 (2006.01); A61P 1/04 (2006.01); A61P 1/16 (2006.01); A61P 3/10 (2006.01); A61P 7/02 (2006.01); A61P 9/00 (2006.01); A61P 9/02 (2006.01); A61P 9/04 (2006.01); A61P 9/10 (2006.01); A61P 11/00 (2006.01); A61P 11/06 (2006.01); A61P 13/12 (2006.01); A61P 17/00 (2006.01); A61P 17/02 (2006.01); A61P 17/06 (2006.01); A61P 19/02 (2006.01); A61P 19/10 (2006.01); A61P 27/02 (2006.01); A61P 29/00 (2006.01); A61P 31/04 (2006.01); A61P 31/12 (2006.01); A61P 31/18 (2006.01); A61P 33/06 (2006.01); A61P 35/00 (2006.01); A61P 43/00 (2006.01); C07D 231/12 (2006.01); C07D 401/04 (2006.01); C07D 401/14 (2006.01); C07D 403/04 (2006.01)
CPC (source: EP)
A61P 1/04 (2017.12); A61P 1/16 (2017.12); A61P 3/10 (2017.12); A61P 7/02 (2017.12); A61P 9/00 (2017.12); A61P 9/02 (2017.12); A61P 9/04 (2017.12); A61P 9/10 (2017.12); A61P 11/00 (2017.12); A61P 11/06 (2017.12); A61P 13/12 (2017.12); A61P 17/00 (2017.12); A61P 17/02 (2017.12); A61P 17/06 (2017.12); A61P 19/02 (2017.12); A61P 19/10 (2017.12); A61P 27/02 (2017.12); A61P 29/00 (2017.12); A61P 31/04 (2017.12); A61P 31/12 (2017.12); A61P 31/18 (2017.12); A61P 33/06 (2017.12); A61P 35/00 (2017.12); A61P 43/00 (2017.12); C07D 401/04 (2013.01); C07D 401/14 (2013.01); C07D 403/04 (2013.01)
Citation (search report)
See references of WO 9958523A1
Designated contracting state (EPC)
AT BE CH DE DK ES FI FR GB GR IE IT LI LU NL PT SE
DOCDB simple family (publication)
WO 9958523 A1 19991118; AU 3859999 A 19991129; CA 2331878 A1 19991118; EP 1077971 A1 20010228; JP 2002514640 A 20020521
DOCDB simple family (application)
US 9907036 W 19990512; AU 3859999 A 19990512; CA 2331878 A 19990512; EP 99921363 A 19990512; JP 2000548327 A 19990512