EP 1078040 A1 20010228 - NT2LP, NOVEL G-PROTEIN COUPLED RECEPTORS HAVING HOMOLOGY TO NEUROTENSIN-2 RECEPTORS
Title (en)
NT2LP, NOVEL G-PROTEIN COUPLED RECEPTORS HAVING HOMOLOGY TO NEUROTENSIN-2 RECEPTORS
Title (de)
NT2LP, neuartige G-Protein gekoppelte Rezeptoren mit Homologie zu Neurotensin-2 Rezeptoren
Title (fr)
NOUVEAUX RECEPTEURS COUPLES A LA PROTEINE-G (NT2LP), PRESENTANT UNE HOMOLOGIE POUR LES RECEPTEURS DE LA NEUROTENSINE-2
Publication
Application
Priority
- US 9910311 W 19990511
- US 7631398 A 19980511
- US 22349298 A 19981230
Abstract (en)
[origin: WO9958641A2] The present invention is based on the identification of a novel G-protein coupled receptor (GPCR) that is expressed predominantly in the brain and nucleic acid molecules that encoded the GPCR, referred to herein as the NT2LP protein and NT2LP gene respectively. The NT2LP protein has high sequence homology to the NT family of receptors, particularly members of the NT2 subfamily. Based on this identification, the present invention provides: 1) isolated NT2LP protein, 2) isolated nucleic acid molecules that encode a NT2LP protein, 3) antibodies that selectively bind to the NT2LP protein, 4) methods of isolating allelic variants of the NT2LP protein and gene, 5) methods of identifying cells and tissues that express the NT2LP protein/gene, 6) methods of identifying agents and cellular compounds that bind to the NT2LP protein, 7) methods of identifying agents that modulate the expression of the NT2LP gene, 8) methods of modulating the activity of the NT2LP protein in a cell or organism and 9) a method for treating diseases, pathologies, or biological processes, for example, pain, comprising administering an agent that binds to and/or modulates NT2LP proteins.
IPC 1-7
IPC 8 full level
C07K 14/705 (2006.01); C07K 14/72 (2006.01); C07K 16/28 (2006.01); C12N 5/10 (2006.01); C12N 15/09 (2006.01); C12P 21/02 (2006.01); C12Q 1/68 (2006.01); G01N 33/15 (2006.01); G01N 33/50 (2006.01); G01N 33/53 (2006.01); G01N 33/566 (2006.01); A61K 38/00 (2006.01)
CPC (source: EP)
C07K 14/723 (2013.01); A61K 38/00 (2013.01)
Designated contracting state (EPC)
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
DOCDB simple family (publication)
WO 9958641 A2 19991118; WO 9958641 A8 20000120; AU 3897699 A 19991129; CA 2327548 A1 19991118; EP 1078040 A1 20010228; EP 1078040 A4 20030102; JP 2003525576 A 20030902
DOCDB simple family (application)
US 9910311 W 19990511; AU 3897699 A 19990511; CA 2327548 A 19990511; EP 99921872 A 19990511; JP 2000548434 A 19990511