Global patent index - EP 1078048 A2

EP 1078048 A2 2001-02-28 - TRANSGENIC ANIMALS PRODUCED BY HOMOLOGOUS SEQUENCE TARGETING

Title (en)

TRANSGENIC ANIMALS PRODUCED BY HOMOLOGOUS SEQUENCE TARGETING

Title (de)

DURCH ZIELEN DER HOMOLOGEN SEQUENZEN HERGESTELLTE TRANSGENTIERE

Title (fr)

ANIMAUX TRANSGENIQUES PRODUITS PAR CIBLAGE DE SEQUENCE HOMOLOGUE

Publication

EP 1078048 A2 (EN)

Application

EP 99924251 A

Priority

  • US 9910731 W
  • US 7987798 A

Abstract (en)

[origin: WO9960108A2] The invention relates to methods and compositions for producing transgenic animals by targeted homologous recombination comprising targeting an exogenous polynucleotide or exogenous complementary polynucleotide pair to a predetermined endogenous DNA target sequence in a target cell by homologous pairing, particularly for altering an endogenous DNA sequence, such as a chromosomal DNA sequence. In certain embodiments, the invention relates to compositions that contain exogenous targeting polynucleotides, complementary pairs of exogenous targeting polynucleotides, chemical substituents of such polynucleotides, and recombinase proteins used in the methods of the invention.

IPC 1-7 (main, further and additional classification)

C12N 15/00; A01K 67/027; A61K 48/00; C07K 14/47; C12N 9/10; C12N 15/90

IPC 8 full level (invention and additional information)

A01K 67/027 (2006.01); C07K 14/47 (2006.01); C12N 9/10 (2006.01); C12N 15/90 (2006.01); A61K 48/00 (2006.01)

CPC (invention and additional information)

A01K 67/0275 (2013.01); C07K 14/4712 (2013.01); C07K 14/4746 (2013.01); C12N 9/1018 (2013.01); C12N 15/907 (2013.01); A01K 2217/05 (2013.01); A01K 2217/075 (2013.01); A61K 48/00 (2013.01)

Citation (search report)

See references of WO 9960108A3

Designated contracting state (EPC)

AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

EPO simple patent family

WO 9960108 A2 19991125; WO 9960108 A3 20000203; AU 4079799 A 19991206; CA 2341350 A1 19991125; EP 1078048 A2 20010228; NZ 508665 A 20030926; NZ 527435 A 20050128

INPADOC legal status

2007-05-23 [18D] DEEMED TO BE WITHDRAWN

- Ref Legal Event Code: 18D

- Effective date: 20061201

2003-07-30 [17Q] FIRST EXAMINATION REPORT

- Ref Legal Event Code: 17Q

- Effective date: 20030616

2001-02-28 [17P] REQUEST FOR EXAMINATION FILED

- Ref Legal Event Code: 17P

- Effective date: 20001213

2001-02-28 [AK] DESIGNATED CONTRACTING STATES:

- Ref Legal Event Code: AK

- Designated State(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE