EP 1078048 A2 20010228 - TRANSGENIC ANIMALS PRODUCED BY HOMOLOGOUS SEQUENCE TARGETING
Title (en)
TRANSGENIC ANIMALS PRODUCED BY HOMOLOGOUS SEQUENCE TARGETING
Title (de)
DURCH ZIELEN DER HOMOLOGEN SEQUENZEN HERGESTELLTE TRANSGENTIERE
Title (fr)
ANIMAUX TRANSGENIQUES PRODUITS PAR CIBLAGE DE SEQUENCE HOMOLOGUE
Publication
Application
Priority
- US 9910731 W 19990514
- US 7987798 A 19980515
Abstract (en)
[origin: WO9960108A2] The invention relates to methods and compositions for producing transgenic animals by targeted homologous recombination comprising targeting an exogenous polynucleotide or exogenous complementary polynucleotide pair to a predetermined endogenous DNA target sequence in a target cell by homologous pairing, particularly for altering an endogenous DNA sequence, such as a chromosomal DNA sequence. In certain embodiments, the invention relates to compositions that contain exogenous targeting polynucleotides, complementary pairs of exogenous targeting polynucleotides, chemical substituents of such polynucleotides, and recombinase proteins used in the methods of the invention.
IPC 1-7
C12N 15/00; A01K 67/027; C12N 15/90; A61K 48/00; C07K 14/47; C12N 9/10
IPC 8 full level
A01K 67/027 (2006.01); C07K 14/47 (2006.01); C12N 9/10 (2006.01); C12N 15/90 (2006.01); A61K 48/00 (2006.01)
CPC (source: EP)
A01K 67/0275 (2013.01); C07K 14/4712 (2013.01); C07K 14/4746 (2013.01); C12N 9/1018 (2013.01); C12N 15/907 (2013.01); A01K 2217/05 (2013.01); A01K 2217/075 (2013.01); A61K 48/00 (2013.01)
Citation (search report)
See references of WO 9960108A2
Designated contracting state (EPC)
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
DOCDB simple family (publication)
WO 9960108 A2 19991125; WO 9960108 A3 20000203; AU 4079799 A 19991206; CA 2341350 A1 19991125; EP 1078048 A2 20010228; NZ 508665 A 20030926; NZ 527435 A 20050128
DOCDB simple family (application)
US 9910731 W 19990514; AU 4079799 A 19990514; CA 2341350 A 19990514; EP 99924251 A 19990514; NZ 50866599 A 19990514; NZ 52743599 A 19990514