Global Patent Index - EP 1079821 A1

EP 1079821 A1 2001-03-07 - PROTEASE INHIBITORS

Title (en)

PROTEASE INHIBITORS

Title (de)

PROTEASE INHIBITOREN

Title (fr)

INHIBITEURS DE LA PROTEASE

Publication

EP 1079821 A1 (EN)

Application

EP 98943273 A

Priority

  • US 9817275 W
  • US 8655398 P

Abstract (en)

[origin: WO9959570A1] The present invention provides diacyl carbohydrazide compounds, and pharmaceutically acceptable salts, hydrates and solvates thereof, which inhibit proteases, including cathepsin K, pharmaceutical compositions of such compounds, novel intermediates of such compounds, and methods for treating diseases of excessive bone loss or cartilage or matrix degradation, including osteoporosis; gingival disease including gingivitis and periodontitis; arthritis, more specifically, osteoarthritis and rheumatoid arthritis; Paget's disease; hypercalcemia of malignancy; and metabolic bone disease, comprising inhibiting said bone loss or excessive cartilage or matrix degradation by administering to a patient in need thereof a compound of the present invention.

IPC 1-7 (main, further and additional classification)

A61K 31/175; A61K 31/34; A61K 31/38; A61K 31/41; A61K 31/42; A61K 31/425; A61K 31/44; A61K 31/47; A61K 31/535; C07C 281/06; C07D 213/54; C07D 217/16; C07D 263/32; C07D 265/30; C07D 277/64; C07D 307/81; C07D 413/04; C07D 495/04

IPC 8 full level (invention and additional information)

C07D 295/08 (2006.01); A61K 31/175 (2006.01); A61K 31/357 (2006.01); A61K 31/44 (2006.01); A61K 31/4402 (2006.01); A61K 31/4406 (2006.01); A61K 31/4427 (2006.01); A61K 31/443 (2006.01); A61K 31/4433 (2006.01); A61K 31/4436 (2006.01); A61K 31/4439 (2006.01); A61K 31/444 (2006.01); A61K 31/4709 (2006.01); A61K 31/472 (2006.01); A61K 31/4725 (2006.01); A61K 31/5375 (2006.01); A61K 31/5377 (2006.01); A61K 38/00 (2006.01); A61P 1/02 (2006.01); A61P 3/12 (2006.01); A61P 19/02 (2006.01); A61P 19/10 (2006.01); A61P 29/00 (2006.01); C07C 281/06 (2006.01); C07D 213/54 (2006.01); C07D 213/56 (2006.01); C07D 213/81 (2006.01); C07D 213/82 (2006.01); C07D 215/48 (2006.01); C07D 217/16 (2006.01); C07D 217/26 (2006.01); C07D 239/34 (2006.01); C07D 263/32 (2006.01); C07D 263/34 (2006.01); C07D 265/30 (2006.01); C07D 277/20 (2006.01); C07D 277/56 (2006.01); C07D 277/62 (2006.01); C07D 277/64 (2006.01); C07D 307/81 (2006.01); C07D 307/84 (2006.01); C07D 321/10 (2006.01); C07D 401/12 (2006.01); C07D 405/12 (2006.01); C07D 409/12 (2006.01); C07D 413/04 (2006.01); C07D 413/12 (2006.01); C07D 417/12 (2006.01); C07D 495/04 (2006.01)

CPC (invention and additional information)

C07D 213/54 (2013.01); C07C 281/06 (2013.01); C07D 217/16 (2013.01); C07D 263/32 (2013.01); C07D 265/30 (2013.01); C07D 277/64 (2013.01); C07D 295/088 (2013.01); C07D 307/81 (2013.01); C07D 401/12 (2013.01); C07D 405/12 (2013.01); C07D 409/12 (2013.01); C07D 413/04 (2013.01); C07D 417/12 (2013.01); C07C 2101/14 (2013.01); C07C 2102/08 (2013.01)

Designated contracting state (EPC)

BE CH DE ES FR GB IT LI NL

EPO simple patent family

WO 9959570 A1 19991125; AU 9110298 A 19991206; CA 2332492 A1 19991125; EP 1079821 A1 20010307; EP 1079821 A4 20010829; JP 2002515428 A 20020528

INPADOC legal status


2003-06-18 [18D] DEEMED TO BE WITHDRAWN

- Ref Legal Event Code: 18D

- Effective date: 20021203

2002-07-03 [17Q] FIRST EXAMINATION REPORT

- Ref Legal Event Code: 17Q

- Effective date: 20020523

2001-08-29 [A4] SUPPLEMENTARY SEARCH REPORT

- Ref Legal Event Code: A4

- Effective date: 20010716

2001-08-29 [AK] DESIGNATED CONTRACTING STATES:

- Ref Legal Event Code: AK

- Designated State(s): BE CH DE ES FR GB IT LI NL

2001-08-29 [RIC1] CLASSIFICATION (CORRECTION)

- Ref Legal Event Code: RIC1

- Free Format Text: 7A 61K 31/175 A, 7A 61K 31/34 B, 7A 61K 31/38 B, 7A 61K 31/41 B, 7A 61K 31/42 B, 7A 61K 31/425 B, 7A 61K 31/44 B, 7A 61K 31/47 B, 7A 61K 31/535 B, 7C 07C 281/06 B, 7C 07D 263/32 B, 7C 07D 307/81 B, 7C 07D 213/54 B, 7C 07D 265/30 B, 7C 07D 277/64 B, 7C 07D 217/16 B, 7C 07D 413/04 B, 7C 07D 409/12 B, 7C 07D 417/12 B, 7C 07D 401/12 B, 7C 07D 405/12 B

2001-03-07 [17P] REQUEST FOR EXAMINATION FILED

- Ref Legal Event Code: 17P

- Effective date: 20001128

2001-03-07 [AK] DESIGNATED CONTRACTING STATES:

- Ref Legal Event Code: AK

- Designated State(s): BE CH DE ES FR GB IT LI NL