Global patent index - EP 1079827 A2

EP 1079827 A2 2001-03-07 - PHARMACEUTICAL PREPARATIONS FOR REGULATING THE RELEASE OF INSULIN BY INFLUENCING THE $g(b)-CELL OF THE PANCREATIC ISLETS OF LANGERHANS

Title (en)

PHARMACEUTICAL PREPARATIONS FOR REGULATING THE RELEASE OF INSULIN BY INFLUENCING THE $g(b)-CELL OF THE PANCREATIC ISLETS OF LANGERHANS

Title (de)

PHARMAZEUTISCHE PRÄPARATE ZUR REGULIERUNG DER INSULIN-FREISETZUNG DURCH BEEINFLUSSUNG DER $g(b)-ZELLE DER PANKREATISCHEN INSELN

Title (fr)

PREPARATION PHARMACEUTIQUE POUR LA REGULATION DE LA LIBERATION DE L'INSULINE PAR ACTION SUR LES CELLULES $g(b) DES ILOTS PANCREATIQUES

Publication

EP 1079827 A2 (DE)

Application

EP 99936315 A

Priority

  • DE 9901541 W
  • DE 19823829 A

Abstract (en)

[origin: DE19823829A1] The invention relates to the use of melatonin and/or its chemically modified derivatives for producing pharmaceutical preparations for regulating the release of insulin by influencing the beta -cell of the pancreatic islets of Langerhans. When used according to the invention, melatonin and/or its chemically modified derivatives have the effect of reducing insulin via membrane-bound G-protein-coupled receptors, gain timer significance through the melatonin receptor since the release of insulin by the pancreatic islets of Langerhans is subject to circadian and ultradian rhythms and significantly statistically reduce the stimulated release of insulin by the pancreatic islets of Langerhans through the melatonin receptor in pharmacological (5 mu M) and physiological (0.2 nM) doses.

IPC 1-7 (main, further and additional classification)

A61K 31/40

IPC 8 full level (invention and additional information)

A61K 31/4045 (2006.01)

CPC (invention and additional information)

A61K 31/4045 (2013.01)

Citation (search report)

See references of WO 9961009A3

Designated contracting state (EPC)

AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

EPO simple patent family

DE 19823829 A1 19991202; AU 5149899 A 19991213; EP 1079827 A2 20010307; WO 9961009 A2 19991202; WO 9961009 A3 20000413

INPADOC legal status

2003-01-02 [18W] WITHDRAWN

- Ref Legal Event Code: 18W

- Date of withdrawal: 20021111

2002-04-24 [17Q] FIRST EXAMINATION REPORT

- Ref Legal Event Code: 17Q

- Effective date: 20020307

2001-03-07 [17P] REQUEST FOR EXAMINATION FILED

- Ref Legal Event Code: 17P

- Effective date: 20001006

2001-03-07 [AK] DESIGNATED CONTRACTING STATES:

- Ref Legal Event Code: AK

- Designated State(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE