EP 1079827 A2 20010307 - PHARMACEUTICAL PREPARATIONS FOR REGULATING THE RELEASE OF INSULIN BY INFLUENCING THE $g(b)-CELL OF THE PANCREATIC ISLETS OF LANGERHANS
Title (en)
PHARMACEUTICAL PREPARATIONS FOR REGULATING THE RELEASE OF INSULIN BY INFLUENCING THE $g(b)-CELL OF THE PANCREATIC ISLETS OF LANGERHANS
Title (de)
PHARMAZEUTISCHE PRÄPARATE ZUR REGULIERUNG DER INSULIN-FREISETZUNG DURCH BEEINFLUSSUNG DER $g(b)-ZELLE DER PANKREATISCHEN INSELN
Title (fr)
PREPARATION PHARMACEUTIQUE POUR LA REGULATION DE LA LIBERATION DE L'INSULINE PAR ACTION SUR LES CELLULES $g(b) DES ILOTS PANCREATIQUES
Publication
Application
Priority
- DE 9901541 W 19990526
- DE 19823829 A 19980528
Abstract (en)
[origin: DE19823829A1] The invention relates to the use of melatonin and/or its chemically modified derivatives for producing pharmaceutical preparations for regulating the release of insulin by influencing the beta -cell of the pancreatic islets of Langerhans. When used according to the invention, melatonin and/or its chemically modified derivatives have the effect of reducing insulin via membrane-bound G-protein-coupled receptors, gain timer significance through the melatonin receptor since the release of insulin by the pancreatic islets of Langerhans is subject to circadian and ultradian rhythms and significantly statistically reduce the stimulated release of insulin by the pancreatic islets of Langerhans through the melatonin receptor in pharmacological (5 mu M) and physiological (0.2 nM) doses.
IPC 1-7
IPC 8 full level
A61K 31/4045 (2006.01)
CPC (source: EP)
A61K 31/4045 (2013.01)
Citation (search report)
See references of WO 9961009A2
Designated contracting state (EPC)
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
DOCDB simple family (publication)
DE 19823829 A1 19991202; AU 5149899 A 19991213; EP 1079827 A2 20010307; WO 9961009 A2 19991202; WO 9961009 A3 20000413
DOCDB simple family (application)
DE 19823829 A 19980528; AU 5149899 A 19990526; DE 9901541 W 19990526; EP 99936315 A 19990526