EP 1080105 A1 20010307 - PHENYLALANINE DERIVATIVES HAVING VLA-4 ANTAGONISTIC ACTIVITY
Title (en)
PHENYLALANINE DERIVATIVES HAVING VLA-4 ANTAGONISTIC ACTIVITY
Title (de)
PHENYLALANINEDERIVATE MIT VLA-4 ANTAGONISTISCHER AKTIVITÄT
Title (fr)
DERIVES PHENILALANINE COMPORTANT UNE ACTIVITE ANTAGONISTE DU VLA-4
Publication
Application
Priority
- GB 9901615 W 19990521
- GB 9811159 A 19980522
Abstract (en)
[origin: WO9961465A1] Phenylalanine derivatives of formula (1) are described, wherein R is a carboxylic acid or a derivative thereof; L<1> is a linker atom or group; and R<5> is a group -L<2>(CH2)tR<6> in which L<2> is a -N(R<7>)CO- or -N(R<7>)CS- group. The compounds are able to inhibit the binding alpha 4 integrins to their ligands and are of use in the prophylaxis and treatment of immune or inflammatory disorders.
IPC 1-7
IPC 8 full level
A61K 31/425 (2006.01); A61K 38/00 (2006.01); A61P 29/00 (2006.01); C07D 213/82 (2006.01); C07K 5/078 (2006.01)
CPC (source: EP US)
A61P 29/00 (2017.12 - EP); C07D 213/82 (2013.01 - EP US); C07K 5/06139 (2013.01 - EP US); A61K 38/00 (2013.01 - EP US)
Citation (search report)
See references of WO 9961465A1
Designated contracting state (EPC)
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
DOCDB simple family (publication)
WO 9961465 A1 19991202; AU 3947599 A 19991213; EP 1080105 A1 20010307; GB 9811159 D0 19980722; JP 2002516336 A 20020604; US 6362204 B1 20020326
DOCDB simple family (application)
GB 9901615 W 19990521; AU 3947599 A 19990521; EP 99922380 A 19990521; GB 9811159 A 19980522; JP 2000550869 A 19990521; US 31708199 A 19990520