EP 1082425 A2 20010314 - ION CHANNELS
Title (en)
ION CHANNELS
Title (de)
IONENKANÄLE
Title (fr)
CANAUX IONIQUES
Publication
Application
Priority
- GB 9901743 W 19990603
- GB 9811965 A 19980603
Abstract (en)
[origin: WO9963081A2] The invention provides acid sensitive cation channel proteins which are capable of reversibly mediating (i) a rapid, and (ii) a sustained cation current, particularly the SPASIC protein or variants (e.g. homologues or fragments) thereof. Also provided are nucleic acids encoding these, or which have utility in probing, amplifying or down-regulating these. Methods of providing the proteins and nucleic acids are disclosed, as are vectors, host cells, and organisms utilising them, and antibodies. Also disclosed are methods of influencing the electrophysiological and/or pharmacological properties of a cell (e.g. by way of therapy) based on manipulation of the proteins or nucleic acids, and methods for screening for substances having ion-channel modulating activity (which may be potential analgesics; neuromodulatory agents; anti-inflammatory agents; agents that regulate neurotransmitter release or neuronal excitability).
IPC 1-7
C12N 15/12; C07K 14/705; C12Q 1/68; C12N 15/85; C12N 5/10; A61K 48/00; A01K 67/027
IPC 8 full level
C07K 14/705 (2006.01); C12N 15/12 (2006.01); A61K 48/00 (2006.01)
CPC (source: EP)
C07K 14/705 (2013.01); A01K 2217/05 (2013.01); A61K 48/00 (2013.01)
Citation (search report)
See references of WO 9963081A2
Designated contracting state (EPC)
CH DE FR GB IT LI SE
DOCDB simple family (publication)
WO 9963081 A2 19991209; WO 9963081 A3 20000127; AU 4156799 A 19991220; EP 1082425 A2 20010314; GB 9811965 D0 19980729
DOCDB simple family (application)
GB 9901743 W 19990603; AU 4156799 A 19990603; EP 99925184 A 19990603; GB 9811965 A 19980603