Global Patent Index - EP 1082431 A2

EP 1082431 A2 2001-03-14 - PROTEASE INHIBITOR PEPTIDES

Title (en)

PROTEASE INHIBITOR PEPTIDES

Title (de)

PROTEASE-INHIBITOR-PEPTIDE

Title (fr)

PEPTIDES INHIBITEURS DE PROTEASE

Publication

EP 1082431 A2 (EN)

Application

EP 99926138 A

Priority

  • US 9912276 W
  • US 8788598 P

Abstract (en)

[origin: WO9963090A2] Analogues of the Kunitz Protease Inhibitor (KPI) domain of amyloid precursor protein bind to an inhibit activity of serine proteases, including kallikrein, plasmin and coagulation factors such as factors VIIa, IXa, Xa, XIa, and XIIa. Pharmaceutical compositions containing the KPI analogs, along with methods for using such compositions, are useful for ameliorating and treating clinical conditions associated with increased serine protease activity, such as blood loss related to cardiopulmonary bypass surgery. Nucleic acid sequences encoding these analogs and systems for expression of the peptides of the invention are provided.

IPC 1-7 (main, further and additional classification)

C12N 15/15; A61K 38/57; C07K 14/81; C12N 1/19; C12N 1/21

IPC 8 full level (invention and additional information)

C12N 15/09 (2006.01); A61K 38/55 (2006.01); A61P 43/00 (2006.01); C07K 14/47 (2006.01); C07K 14/81 (2006.01); C12N 1/19 (2006.01); C12N 1/21 (2006.01); C12N 15/15 (2006.01); C12P 21/02 (2006.01); A61K 38/00 (2006.01); C12R 1/865 (2006.01)

CPC (invention and additional information)

C07K 14/8114 (2013.01); C07K 14/4711 (2013.01); A61K 38/00 (2013.01)

Citation (search report)

See references of WO 9963090A3

Designated contracting state (EPC)

AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

EPO simple patent family

WO 9963090 A2 19991209; WO 9963090 A3 20000302; AU 4229599 A 19991220; CA 2330191 A1 19991209; EP 1082431 A2 20010314; JP 2002517197 A 20020618

INPADOC legal status


2004-08-25 [18D] DEEMED TO BE WITHDRAWN

- Effective date: 20040217

2001-03-14 [17P] REQUEST FOR EXAMINATION FILED

- Effective date: 20010103

2001-03-14 [AK] DESIGNATED CONTRACTING STATES:

- Kind Code of Ref Document: A2

- Designated State(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE