EP 1083935 A1 20010321 - PROSTHETIC IMPLANT AND METHODS OF USE FOR THERAPEUTIC GENE EXPRESSION
Title (en)
PROSTHETIC IMPLANT AND METHODS OF USE FOR THERAPEUTIC GENE EXPRESSION
Title (de)
PROSTHETISCHES IMPLANTAT UND VERFAHREN ZUR VERWENDUNG FÜR THERAPEUTISCHE GENEXPRESSION
Title (fr)
IMPLANT PROTHETIQUE ET TECHNIQUES D'UTILISATION AUX FINS DE L'EXPRESSION DE GENES THERAPEUTIQUES
Publication
Application
Priority
- US 9912116 W 19990601
- US 8765998 P 19980602
Abstract (en)
[origin: WO9962562A1] The invention provides a method of systemic delivery of a gene product to an individual. The method consists of implanting within the wall of the digestive tract of an individual a prosthetic chamber containing an effective amount of cells secreting the gene product. The prosthetic chamber can be implanted within or proximal to a connective tissue layer including, for example, between the tunica serosa and the tunica muscularis of the digestive tract wall. The gene product to be delivered can be selected from cytokines, hormones, growth factors and blood clotting factors including, for example, Epo or insulin. Expression of the gene product can be constitutive or inducible. Therefor, the invention provides a method of treating a pathology mediated by the deficiency of a gene product. The method consists of implanting a prosthetic chamber containing an effective amount of cells expressing therapeutic levels of the deficient gene product.
IPC 1-7
IPC 8 full level
A61K 38/18 (2006.01); A61K 48/00 (2006.01); A61P 5/00 (2006.01)
CPC (source: EP)
A61K 38/1816 (2013.01); A61K 48/00 (2013.01); A61P 5/00 (2017.12)
Citation (search report)
See references of WO 9962562A1
Designated contracting state (EPC)
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
DOCDB simple family (publication)
WO 9962562 A1 19991209; AU 4410799 A 19991220; CA 2330172 A1 19991209; DE 1083935 T1 20011220; EP 1083935 A1 20010321; ES 2157874 T1 20010901; GR 20010300045 T1 20010831
DOCDB simple family (application)
US 9912116 W 19990601; AU 4410799 A 19990601; CA 2330172 A 19990601; DE 99927128 T 19990601; EP 99927128 A 19990601; ES 99927128 T 19990601; GR 20010300045 T 20010831