EP 1083951 A1 20010321 - METHODS OF DELIVERING AEROSOLIZED POLYNUCLEOTIDES TO THE RESPIRATORY TRACT
Title (en)
METHODS OF DELIVERING AEROSOLIZED POLYNUCLEOTIDES TO THE RESPIRATORY TRACT
Title (de)
METHODE ZUR AUSTRAGUNG VON POLYNUKLEOTIDE IN FORM EINES AEROSOLS IN DEN RESPIRATIONSTRAKT
Title (fr)
METHODES D'ADMINISTRATION DE POLYNUCLEOTIDES SOUS FORME D'AEROSOLS A L'APPAREILS RESPIRATOIRES
Publication
Application
Priority
- US 9913306 W 19990611
- US 8914698 P 19980612
Abstract (en)
[origin: WO9964094A1] Methods and devices for delivering aerosolized formulations containing polynucleotides to specified regions within a subject's respiratory tract are disclosed. The methods find use in the delivery of ribozymes, antisense polynucleotides, and DNA and RNA expression vectors into airway epithelial cells, alveoli, pulmonary macrophages and other cells in the respiratory tract (including the oropharynx, nose, nasopharynx). These methods may be used for optimization of transfection efficiency and expression in vivo, and for in vivo expression, for example for generating an immune response, or inducing immunological tolerance.
IPC 1-7
IPC 8 full level
A61K 9/00 (2006.01); A61K 48/00 (2006.01); A61M 15/00 (2006.01); A61M 16/10 (2006.01)
CPC (source: EP)
A61K 9/0075 (2013.01); A61K 48/00 (2013.01)
Designated contracting state (EPC)
DE ES FR GB IT
DOCDB simple family (publication)
WO 9964094 A1 19991216; AU 4680699 A 19991230; EP 1083951 A1 20010321; EP 1083951 A4 20040707
DOCDB simple family (application)
US 9913306 W 19990611; AU 4680699 A 19990611; EP 99930226 A 19990611