Global patent index - EP 1083951 A1

EP 1083951 A1 2001-03-21 - METHODS OF DELIVERING AEROSOLIZED POLYNUCLEOTIDES TO THE RESPIRATORY TRACT

Title (en)

METHODS OF DELIVERING AEROSOLIZED POLYNUCLEOTIDES TO THE RESPIRATORY TRACT

Title (de)

METHODE ZUR AUSTRAGUNG VON POLYNUKLEOTIDE IN FORM EINES AEROSOLS IN DEN RESPIRATIONSTRAKT

Title (fr)

METHODES D'ADMINISTRATION DE POLYNUCLEOTIDES SOUS FORME D'AEROSOLS A L'APPAREILS RESPIRATOIRES

Publication

EP 1083951 A1 (EN)

Application

EP 99930226 A

Priority

  • US 9913306 W
  • US 8914698 P

Abstract (en)

[origin: WO9964094A1] Methods and devices for delivering aerosolized formulations containing polynucleotides to specified regions within a subject's respiratory tract are disclosed. The methods find use in the delivery of ribozymes, antisense polynucleotides, and DNA and RNA expression vectors into airway epithelial cells, alveoli, pulmonary macrophages and other cells in the respiratory tract (including the oropharynx, nose, nasopharynx). These methods may be used for optimization of transfection efficiency and expression in vivo, and for in vivo expression, for example for generating an immune response, or inducing immunological tolerance.

IPC 1-7 (main, further and additional classification)

A61M 15/00; A61M 11/00

IPC 8 full level (invention and additional information)

A61K 9/00 (2006.01); A61K 48/00 (2006.01); A61M 15/00 (2006.01); A61M 16/10 (2006.01)

CPC (invention and additional information)

A61K 9/0075 (2013.01); A61K 48/00 (2013.01)

Designated contracting state (EPC)

DE ES FR GB IT

EPO simple patent family

WO 9964094 A1 19991216; AU 4680699 A 19991230; EP 1083951 A1 20010321; EP 1083951 A4 20040707

INPADOC legal status

2006-01-04 [18D] DEEMED TO BE WITHDRAWN

- Ref Legal Event Code: 18D

- Effective date: 20050629

2005-04-06 [17Q] FIRST EXAMINATION REPORT

- Ref Legal Event Code: 17Q

- Effective date: 20050218

2004-07-07 [A4] SUPPLEMENTARY SEARCH REPORT

- Ref Legal Event Code: A4

- Effective date: 20040525

2004-07-07 [RIC1] CLASSIFICATION (CORRECTION)

- Ref Legal Event Code: RIC1

- IPC: 7A 61M 15/00 A

2004-07-07 [RIC1] CLASSIFICATION (CORRECTION)

- Ref Legal Event Code: RIC1

- IPC: 7A 61M 11/00 B

2001-03-21 [17P] REQUEST FOR EXAMINATION FILED

- Ref Legal Event Code: 17P

- Effective date: 20001221

2001-03-21 [AK] DESIGNATED CONTRACTING STATES:

- Ref Legal Event Code: AK

- Designated State(s): DE ES FR GB IT