EP 1084122 B1 20031022 - TETRAHYDRONAPHTHYRIDINYL-CARBOXAMIDES HAVING ANTI-CONVULSANT ACTIVITY
Title (en)
TETRAHYDRONAPHTHYRIDINYL-CARBOXAMIDES HAVING ANTI-CONVULSANT ACTIVITY
Title (de)
TETRAHYDRONAPHTHYRIDINYL-CARBOXAMIDE MIT ANTICONVULSIVER WIRKUNG
Title (fr)
TETRAHYDRONAPHTYRIDINYL-CARBOXAMIDES PRESENTANT UNE ACTIVITE ANTI-CONVULSIVANTE
Publication
Application
Priority
- GB 9901826 W 19990609
- GB 9812683 A 19980612
Abstract (en)
[origin: WO9965903A1] Compounds of formula (I) and pharmaceutically acceptable salts and solvates: where R<1> is hydrogen, C1-6alkyl (optionally substituted by hydroxy or C1-4alkoxy), phenyl-C1-4alkyl-, C1-6alkenyl, C1-6alkynyl; R<2> is hydrogen or up to three substituents selected from halogen, NO2, CN, N3, CF3O-, CF3S-, CF3SO2-, CF3CO-, C1-6alkyl, C1-6alkenyl, C1-6alkynyl, C1-6perfluoroalkyl, C3-6cycloalkyl, C3-6cycloalkyl-C1-4alkyl-, C1-6alkylO-, C1-6alkylCO-, C3-6cycloalkylO-, C3-6cycloalkylCO-, C3-6cycloalkyl-C1-4alkylO-, C3-6cycloalkyl-C1-4alkylCO-, phenyl, phenoxy, benzyloxy, benzoyl, phenyl-C1-4alkyl-, C1-6alkylS-, C1-6alkylSO2-, (C1-4alkyl)2NSO2-, (C1-4alkyl)NHSO2-, (C1-4alkyl)2NCO-, (C1-4alkyl)NHCO- or CONH2; or -NR<5>R<6> where R<5> is hydrogen or C1-4alkyl, and R<6> is hydrogen, C1-4alkyl, formyl, -CO2C1-4alkyl or -COC1-4alkyl; or two R<2> groups together form a carbocyclic ring that is saturated or unsaturated, optionally interrupted by O or NH; R<3> groups and R<4> groups are each independently hydrogen or C1-6alkyl and/or the two R<3> groups and/or the two R<4> groups together form a C3-6spiroalkyl group, provided that at least one R<3> or R<4> group is not hydrogen; and X is selected from hydrogen, halogen, cyano, alkyl and alkoxy, are useful in the treatment and prophylaxis of epilepsy, migraine, and other disorders.
IPC 1-7
IPC 8 full level
A61K 31/4375 (2006.01); A61P 19/02 (2006.01); A61P 21/00 (2006.01); A61P 25/00 (2006.01); A61P 25/04 (2006.01); A61P 25/06 (2006.01); A61P 25/08 (2006.01); A61P 25/14 (2006.01); A61P 25/16 (2006.01); A61P 25/18 (2006.01); A61P 25/20 (2006.01); A61P 25/22 (2006.01); A61P 25/24 (2006.01); A61P 25/28 (2006.01); A61P 25/30 (2006.01); A61P 25/32 (2006.01); A61P 25/34 (2006.01); A61P 43/00 (2006.01); C07D 471/04 (2006.01); C07D 471/10 (2006.01)
CPC (source: EP KR US)
A61P 19/02 (2017.12 - EP); A61P 21/00 (2017.12 - EP); A61P 25/00 (2017.12 - EP); A61P 25/04 (2017.12 - EP); A61P 25/06 (2017.12 - EP); A61P 25/08 (2017.12 - EP); A61P 25/14 (2017.12 - EP); A61P 25/16 (2017.12 - EP); A61P 25/18 (2017.12 - EP); A61P 25/20 (2017.12 - EP); A61P 25/22 (2017.12 - EP); A61P 25/24 (2017.12 - EP); A61P 25/26 (2017.12 - EP); A61P 25/28 (2017.12 - EP); A61P 25/30 (2017.12 - EP); A61P 25/32 (2017.12 - EP); A61P 25/34 (2017.12 - EP); A61P 31/18 (2017.12 - EP); A61P 43/00 (2017.12 - EP); C07D 471/04 (2013.01 - EP KR US); C07D 471/10 (2013.01 - EP US)
Designated contracting state (EPC)
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
DOCDB simple family (publication)
WO 9965903 A1 19991223; AP 2000002009 A0 20001231; AR 018656 A1 20011128; AT E252579 T1 20031115; AU 4280099 A 20000105; AU 750470 B2 20020718; BG 105126 A 20011130; BR 9911110 A 20011030; CA 2334900 A1 19991223; CN 1311789 A 20010905; CO 5040081 A1 20010529; CZ 20004611 A3 20010613; CZ 293010 B6 20040114; DE 69912278 D1 20031127; DE 69912278 T2 20040812; EA 200100033 A1 20010625; EP 1084122 A1 20010321; EP 1084122 B1 20031022; ES 2209524 T3 20040616; GB 9812683 D0 19980812; HU P0102773 A2 20020128; HU P0102773 A3 20020930; ID 27593 A 20010412; IL 140171 A0 20020210; JP 2002518390 A 20020625; KR 20010052792 A 20010625; MA 26646 A1 20041220; NO 20006269 D0 20001211; NO 20006269 L 20010207; NZ 508799 A 20030829; PE 20000727 A1 20000928; PL 344791 A1 20011119; SK 18962000 A3 20010806; TR 200003694 T2 20010621; TW 495510 B 20020721; US 2002143029 A1 20021003; US 6410555 B1 20020625; US 6762192 B2 20040713; ZA 200007397 B 20020227
DOCDB simple family (application)
GB 9901826 W 19990609; AP 2000002009 A 19990609; AR P990102772 A 19990610; AT 99957056 T 19990609; AU 4280099 A 19990609; BG 10512601 A 20010108; BR 9911110 A 19990609; CA 2334900 A 19990609; CN 99809413 A 19990609; CO 99036865 A 19990611; CZ 20004611 A 19990609; DE 69912278 T 19990609; EA 200100033 A 19990609; EP 99957056 A 19990609; ES 99957056 T 19990609; GB 9812683 A 19980612; HU P0102773 A 19990609; ID 20002580 A 19990609; IL 14017199 A 19990609; JP 2000554728 A 19990609; KR 20007014099 A 20001212; MA 25618 A 19990610; NO 20006269 A 20001211; NZ 50879999 A 19990609; PE 00051999 A 19990611; PL 34479199 A 19990609; SK 18962000 A 19990609; TR 200003694 T 19990609; TW 88109749 A 19990611; US 15499702 A 20020523; US 71933501 A 20010216; ZA 200007397 A 20001212