Global patent index - EP 1084140 A1

EP 1084140 A1 2001-03-21 - PREPARATION AND PURIFICATION OF A SALT OF ASPARTAME WITH ACESULFAM K

Title (en)

PREPARATION AND PURIFICATION OF A SALT OF ASPARTAME WITH ACESULFAM K

Title (de)

BEREITSTELLUNG UND REINIGUNG EINES SALZES VON ASPARTAM MIT ACESULFAM-K

Title (fr)

PREPARATION ET PURIFICATION D'UN SEL ORGANIQUE D'ASPARTAME AU MOYEN D'ACESULFAME-K

Publication

EP 1084140 A1 (EN)

Application

EP 99925472 A

Priority

  • NL 9900339 W
  • NL 1009323 A

Abstract (en)

[origin: WO9964445A1] The invention relates to a process for the preparation of the salt of aspartame and acesulphamic acid wherein the salt of aspartame and acesulphamic acid is made available as a wet solid crystalline product which upon drying results in a product having a particle-size distribution in which at least 10 wt.% of the particles is larger than 200 mu m. This crystalline product has an improved stability as compared with the product of the state of the art. In one embodiment the wet solid crystalline product is also subjected, prior to the drying operation, to a washing operation with a basic aqueous solution having a pH of 8 or higher. The invention also relates to the salt of aspartame and acesulphamic acid having such an increased stability that the acetoacetamide content upon heating of that salt in dry form at a temperature of 80 DEG C for 48 hours remains lower than 10 ppm relative to the dry weight of the salt. In dried form, such salt of aspartame and acesulphamic acid has a particle-size distribution in which at least 10 wt.%, and more in particular at least 25 wt.%, of the particles is larger than 200 mu m.

IPC 1-7 (main, further and additional classification)

C07K 5/075; A23L 1/236

IPC 8 full level (invention and additional information)

A23L 27/30 (2016.01); C07K 5/075 (2006.01)

CPC (invention and additional information)

C07K 5/0613 (2013.01); A23L 27/32 (2016.08)

Designated contracting state (EPC)

DE FR GB NL

EPO simple patent family

WO 9964445 A1 19991216; AU 4173899 A 19991230; CN 1304415 A 20010718; EP 1084140 A1 20010321; JP 2002517511 A 20020618; NL 1009323 C2 19991207

INPADOC legal status

2002-05-08 [18D] DEEMED TO BE WITHDRAWN

- Ref Legal Event Code: 18D

- Effective date: 20011026

2001-08-01 [17Q] FIRST EXAMINATION REPORT

- Ref Legal Event Code: 17Q

- Effective date: 20010615

2001-03-21 [17P] REQUEST FOR EXAMINATION FILED

- Ref Legal Event Code: 17P

- Effective date: 20001018

2001-03-21 [AK] DESIGNATED CONTRACTING STATES:

- Ref Legal Event Code: AK

- Designated State(s): DE FR GB NL