Global Patent Index - EP 1084242 A2

EP 1084242 A2 2001-03-21 - PHAGOCYTIC ASSAY METHOD

Title (en)

PHAGOCYTIC ASSAY METHOD

Title (de)

VERFAHREN EINES PHAGOZYTOSE-ASSAYS

Title (fr)

PROCEDE D'ANALYSE PHAGOCYTAIRE

Publication

EP 1084242 A2 (EN)

Application

EP 99929185 A

Priority

  • EP 9904043 W
  • GB 9812660 A
  • GB 9820816 A

Abstract (en)

[origin: WO9964586A2] The invention provides assay methods for determining whether a compound is an enhancer or an inhibitor of a signal transduction pathway which promotes phagocytosis of apoptotic cells. The methods involve exposing a phagocytic cell to apoptotic cells, optionally transfected with a reporter gene, and measuring the extent of phagocytosis in the presence or absence of the test compound. Expression vectors are provided to transfect mammalian cells with DNA sequences which when expressed influence the rate of phagocytosis of apoptotic cells such as the human homologue of the C. elegans ced-6 gene.

IPC 1-7 (main, further and additional classification)

C12N 15/12; A61K 38/17; C07K 14/435; C07K 14/47; C07K 16/18; C12N 5/10; C12N 15/62; C12Q 1/68; G01N 33/50; G01N 33/563

IPC 8 full level (invention and additional information)

G01N 33/50 (2006.01); A01K 67/027 (2006.01); A61K 38/00 (2006.01); A61K 39/395 (2006.01); A61P 43/00 (2006.01); C07K 14/435 (2006.01); C07K 14/47 (2006.01); C07K 16/18 (2006.01); C07K 19/00 (2006.01); C12N 5/10 (2006.01); C12N 15/09 (2006.01); C12N 15/12 (2006.01); C12Q 1/02 (2006.01); C12Q 1/34 (2006.01); C12Q 1/66 (2006.01); C12Q 1/68 (2006.01); G01N 33/563 (2006.01)

CPC (invention and additional information)

C07K 14/4702 (2013.01); C07K 14/43545 (2013.01); A01K 2217/05 (2013.01)

Citation (search report)

See references of WO 9964586A3

Designated contracting state (EPC)

AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

EPO simple patent family

WO 9964586 A2 19991216; WO 9964586 A3 20000427; AU 4608499 A 19991230; BR 9911097 A 20010213; CA 2332993 A1 19991216; CN 1305525 A 20010725; EP 1084242 A2 20010321; HU 0102349 A2 20011028; IL 140016 D0 20020210; JP 2002517238 A 20020618; PL 345951 A1 20020114

INPADOC legal status


2008-01-18 [REG HK WD] APPLICATIONS WITHDRAWN, DEEMED TO BE WITHDRAWN, OR REFUSED AFTER PUBLICATION IN HONG KONG

- Document: HK 1038376

2003-07-02 [18D] DEEMED TO BE WITHDRAWN

- Effective date: 20030103

2001-03-21 [17P] REQUEST FOR EXAMINATION FILED

- Effective date: 20010104

2001-03-21 [AK] DESIGNATED CONTRACTING STATES:

- Kind Code of Ref Document: A2

- Designated State(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE