EP 1085857 A2 20010328 - CATIONIC AMPHIPHILE MICELLAR COMPLEXES
Title (en)
CATIONIC AMPHIPHILE MICELLAR COMPLEXES
Title (de)
KATIONISCHE AMPHIPHILE MIZELLENARTIGE KOMPLEXE
Title (fr)
COMPLEXES MICELLAIRES D'AMPHIPHILES CATIONIQUES
Publication
Application
Priority
- US 9913875 W 19990618
- US 8987998 P 19980619
Abstract (en)
[origin: WO9965461A2] The effective introduction of foreign genes and other biologically active molecules into targeted mammalian cells is a challenge still facing those skilled in the art. Gene therapy, for example, requires successful transfection of target cells in a patient. The present invention relates to novel micellar complexes of cationic amphiphilic compounds that facilitate delivery of biologically active molecules to the targeted cells of a mammal. The novel micellar complexes are comprised of a cationic amphiphile, a biologically active molecule, a derivative of polyethylene glycol (PEG), and optionally, a co-lipid. A further aspect of the invention is the use of targeting absents in any of the methods that effectuate the delivery of biologically active molecules into the cells of mammals. A targeting agent is usually any molecule, peptide sequence, or large protein that preferentially targets or binds to specific mammalian cells.
IPC 1-7
IPC 8 full level
C12N 15/00 (2006.01); A61K 9/00 (2006.01); A61K 9/127 (2006.01); A61K 31/711 (2006.01); A61K 39/395 (2006.01); A61K 47/24 (2006.01); A61K 47/34 (2006.01); A61K 47/42 (2006.01); A61K 47/44 (2006.01); A61K 47/48 (2006.01); A61K 48/00 (2006.01)
CPC (source: EP)
A61K 9/1272 (2013.01); A61K 47/6907 (2017.07); A61K 47/6911 (2017.07)
Citation (search report)
See references of WO 9965461A2
Designated contracting state (EPC)
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
DOCDB simple family (publication)
WO 9965461 A2 19991223; WO 9965461 A3 20000224; WO 9965461 A9 20010201; AU 4698499 A 20000105; CA 2335638 A1 19991223; EP 1085857 A2 20010328; JP 2002518313 A 20020625
DOCDB simple family (application)
US 9913875 W 19990618; AU 4698499 A 19990618; CA 2335638 A 19990618; EP 99930442 A 19990618; JP 2000554341 A 19990618