Global Patent Index - EP 1085857 A2

EP 1085857 A2 2001-03-28 - CATIONIC AMPHIPHILE MICELLAR COMPLEXES

Title (en)

CATIONIC AMPHIPHILE MICELLAR COMPLEXES

Title (de)

KATIONISCHE AMPHIPHILE MIZELLENARTIGE KOMPLEXE

Title (fr)

COMPLEXES MICELLAIRES D'AMPHIPHILES CATIONIQUES

Publication

EP 1085857 A2 (EN)

Application

EP 99930442 A

Priority

  • US 9913875 W
  • US 8987998 P

Abstract (en)

[origin: WO9965461A2] The effective introduction of foreign genes and other biologically active molecules into targeted mammalian cells is a challenge still facing those skilled in the art. Gene therapy, for example, requires successful transfection of target cells in a patient. The present invention relates to novel micellar complexes of cationic amphiphilic compounds that facilitate delivery of biologically active molecules to the targeted cells of a mammal. The novel micellar complexes are comprised of a cationic amphiphile, a biologically active molecule, a derivative of polyethylene glycol (PEG), and optionally, a co-lipid. A further aspect of the invention is the use of targeting absents in any of the methods that effectuate the delivery of biologically active molecules into the cells of mammals. A targeting agent is usually any molecule, peptide sequence, or large protein that preferentially targets or binds to specific mammalian cells.

IPC 1-7 (main, further and additional classification)

A61K 9/127; A61K 39/44; A61K 48/00; C12N 15/63; C12N 15/88

IPC 8 full level (invention and additional information)

C12N 15/00 (2006.01); A61K 9/00 (2006.01); A61K 9/127 (2006.01); A61K 31/711 (2006.01); A61K 39/395 (2006.01); A61K 47/24 (2006.01); A61K 47/34 (2006.01); A61K 47/42 (2006.01); A61K 47/44 (2006.01); A61K 47/48 (2006.01); A61K 48/00 (2006.01)

CPC (invention and additional information)

A61K 9/1272 (2013.01); A61K 47/488 (2013.01); A61K 47/48815 (2013.01)

Citation (search report)

See references of WO 9965461A3

Designated contracting state (EPC)

AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

EPO simple patent family

WO 9965461 A2 19991223; WO 9965461 A3 20000224; WO 9965461 A9 20010201; AU 4698499 A 20000105; CA 2335638 A1 19991223; EP 1085857 A2 20010328; JP 2002518313 A 20020625

INPADOC legal status


2003-05-02 [18W] WITHDRAWN

- Effective date: 20030301

2001-06-13 [17Q] FIRST EXAMINATION REPORT

- Effective date: 20010427

2001-06-13 [RIN1] INVENTOR (CORRECTION)

- Inventor name: TOUSIGNANT, JENNIFER, D.

2001-06-13 [RIN1] INVENTOR (CORRECTION)

- Inventor name: EASTMAN, SIMON, J.

2001-06-13 [RIN1] INVENTOR (CORRECTION)

- Inventor name: CHU, QUIMING

2001-06-13 [RIN1] INVENTOR (CORRECTION)

- Inventor name: LEE, EDWARD, R.

2001-06-13 [RIN1] INVENTOR (CORRECTION)

- Inventor name: NIETUPSKI, JANNIFER

2001-06-13 [RIN1] INVENTOR (CORRECTION)

- Inventor name: SCHEULE, RONALD

2001-06-13 [RIN1] INVENTOR (CORRECTION)

- Inventor name: CHENG, SENG

2001-06-13 [RIN1] INVENTOR (CORRECTION)

- Inventor name: MARSHALL, JOHN

2001-03-28 [17P] REQUEST FOR EXAMINATION FILED

- Effective date: 20001215

2001-03-28 [AK] DESIGNATED CONTRACTING STATES:

- Kind Code of Ref Document: A2

- Designated State(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE