Global patent index - EP 1085867 A1

EP 1085867 A1 2001-03-28 - THERAPEUTIC COMBINATIONS OF (SELECTIVE) ESTROGEN RECEPTOR MODULATORS (SERM) AND GROWTH HORMONE SECRETAGOGUES (GHS) FOR TREATING MUSCULOSKELETAL FRAILTY

Title (en)

THERAPEUTIC COMBINATIONS OF (SELECTIVE) ESTROGEN RECEPTOR MODULATORS (SERM) AND GROWTH HORMONE SECRETAGOGUES (GHS) FOR TREATING MUSCULOSKELETAL FRAILTY

Title (de)

THERAPEUTISCHE KOMBINATIONEN AUS (SELEKTIVE) ESTROGEN-REZEPTOR MODULATOREN (SERM) UND WACHSTUMSHORMONSEKRETIONSFÖRDERER (GHS) ZUR BEHANDLUNG VON MUSKELSKELETT-GEBRECHLICHKEIT

Title (fr)

COMBINAISONS THERAPEUTIQUES DE MODULATEURS (SELECTIFS) DES RECEPTEURS DES OESTROGENES (SERM) ET DE SECRETAGOGUES D'HORMONES DE CROISSANCE (GHS) POUR TRAITER LA FRAGILITE MUSCULO-SQUELETTIQUE

Publication

EP 1085867 A1 (EN)

Application

EP 99914723 A

Priority

  • IB 9900796 W
  • US 8942498 P

Abstract (en)

[origin: WO9965488A1] This invention is directed to pharmaceutical combination compositions and methods comprising (-)-cis-6- phenyl-5-(4- (2-pyrrolidin-1- yl-ethoxy) -phenyl)- 5,6,7,8- tetrahydronaphthalene -2-ol or a pharmaceutically acceptable salt thereof and 2-amino-N-(1(R) -(2,4-difluoro- benzyloxymethyl) -2-oxo-2-(3- oxo-3a(R) -pyridin-2- ylmethyl)-2-( 2,2,2-trifluoro-ethyl) -2,3,3a,4,6,7 -hexahydro -pyrazolo [4,3-c]pyridin -5-yl)-ethyl) -2-methyl-propionamide or a pharmaceutically acceptable salt thereof, methods of using such compositions and kits containing such compositions. The compositions are useful for treating musculoskeletal frailty, including osteoporosis, osteoporotic fracture, low bone mass, frailty and low muscle mass.

IPC 1-7 (main, further and additional classification)

A61K 31/44

IPC 8 full level (invention and additional information)

C07D 295/08 (2006.01); A61K 31/40 (2006.01); A61K 31/402 (2006.01); A61K 31/435 (2006.01); A61K 31/437 (2006.01); A61K 31/44 (2006.01); A61K 31/444 (2006.01); A61P 1/02 (2006.01); A61P 19/00 (2006.01); A61P 19/08 (2006.01); A61P 19/10 (2006.01); A61P 43/00 (2006.01); C07D 471/04 (2006.01)

IPC 8 main group level (invention and additional information)

A61K (2006.01); C07D (2006.01)

CPC (invention and additional information)

A61K 31/44 (2013.01)

Combination set (CPC)

  1. A61K 31/44 + A61K 31/40
  2. A61K 31/44 + A61K 2300/00

Citation (search report)

See references of WO 9965488A1

Designated contracting state (EPC)

AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU NL PT SE

EPO simple patent family

WO 9965488 A1 19991223; AP 9901581 D0 19990630; AR 018868 A1 20011212; AU 3342099 A 20000105; BG 105128 A 20011130; BR 9911357 A 20010313; CA 2335112 A1 19991223; CN 1305378 A 20010725; CO 5070586 A1 20010828; EP 1085867 A1 20010328; GT 199900083 A 20001205; HR P20000857 A2 20011031; HU 0102395 A2 20011128; ID 26726 A 20010201; IL 139587 D0 20020210; IS 5727 A 20001124; JP 2002518328 A 20020625; MA 26648 A1 20041220; NO 20006381 A 20001214; NO 20006381 D0 20001214; OA 11569 A 20040701; PA 8472101 A1 20000929; PE 06332000 A1 20000726; PL 345064 A1 20011119; SK 18902000 A3 20011203; TN SN99118 A1 20030403; UY 25557 A1 20010131; ZA 9903973 B 20001215

INPADOC legal status

2004-06-30 [18D] DEEMED TO BE WITHDRAWN

- Ref Legal Event Code: 18D

- Effective date: 20031202

2001-03-28 [17P] REQUEST FOR EXAMINATION FILED

- Ref Legal Event Code: 17P

- Effective date: 20001127

2001-03-28 [AK] DESIGNATED CONTRACTING STATES:

- Ref Legal Event Code: AK

- Designated State(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU NL PT SE

2001-03-28 [AX] REQUEST FOR EXTENSION OF THE EUROPEAN PATENT TO

- Ref Legal Event Code: AX

- Free Format Text: AL PAYMENT 20001127;LT PAYMENT 20001127;LV PAYMENT 20001127;MK PAYMENT 20001127;RO PAYMENT 20001127;SI PAYMENT 20001127