Global Patent Index - EP 1085881 A1

EP 1085881 A1 2001-03-28 - PHARMACEUTICAL COMPOSITIONS CONTAINING ALPHA-TOCOPHERYLPHOSPHOCHOLINE

Title (en)

PHARMACEUTICAL COMPOSITIONS CONTAINING ALPHA-TOCOPHERYLPHOSPHOCHOLINE

Title (de)

PHARMAZEUTISCHE ZUSAMMENSETZUNGEN ENTHALTEND ALPHA-TOCOPHERYLPHOSPHOCHOLIN

Title (fr)

COMPOSITIONS PHARMACEUTIQUES CONTENANT DE L'ALPHA-TOCOPHERYLPHOSPHOCHOLINE

Publication

EP 1085881 A1 (EN)

Application

EP 98926417 A

Priority

US 9811818 W

Abstract (en)

[origin: WO9964015A1] alpha -Tocopherylphosphocholine and salts thereof have been discovered to possess antiviral, anti-fungal, anti-inflammatory, PAF-antagonist, and ultra-violet radiation-blocking activities. The compounds are effective to treat a variety of ailments, including diseases of the airways and pulmonary passages. The compound and salts have also been discovered to be capable of forming liposomes. The present invention thus provides methods of treating viral and fungal infections, respiratory disorders, inflammatory disorders and pathophysiological conditions due to PAF activity in a mammal by administering to the mammal alpha -tocopherylphosphocholine or a pharmaceutically acceptable salt thereof. The invention also provides pharmaceutical compositions comprising alpha -tocopherylphosphocholine or a pharmaceutically acceptable salt thereof and a pharmaceutically acceptable carrier. Further, the invention provides liposomes which comprise alpha -tocopherylphosphocholine or a salt thereof as a structural component of the liposome bilayer.

[origin: WO9964015A1] alpha -Tocopherylphosphocholine and salts thereof have been discovered to possess antiviral, anti-fungal, anti-inflammatory, PAF-antagonist, and ultra-violet radiation-blocking activities. The compounds are effective to treat a variety of ailments, including diseases of the airways and pulmonary passages. The compound and salts have also been discovered to be capable of forming liposomes. The present invention thus provides methods of treating viral and fungal infections, respiratory disorders, inflammatory disorders and pathophysiological conditions due to PAF activity in a mammal by administering to the mammal alpha -tocopherylphosphocholine or a pharmaceutically acceptable salt thereof. The invention also provides pharmaceutical compositions comprising alpha -tocopherylphosphocholine or a pharmaceutically acceptable salt thereof and a pharmaceutically acceptable carrier. Further, the invention provides liposomes which comprise alpha -tocopherylphosphocholine or a salt thereof as a structural component of the liposome bilayer.

IPC 1-7 (main, further and additional classification)

A61K 31/66

IPC 8 full level (invention and additional information)

A61K 31/665 (2006.01)

CPC (invention and additional information)

A61K 31/685 (2013.01); A61K 31/665 (2013.01)

Citation (search report)

See references of WO 9964015A1

Designated contracting state (EPC)

AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

EPO simple patent family

WO 9964015 A1 19991216; AU 7826198 A 19991230; CA 2334313 A1 19991216; EP 1085881 A1 20010328

INPADOC legal status


2002-07-10 [18D] DEEMED TO BE WITHDRAWN

- Ref Legal Event Code: 18D

- Effective date: 20020103

2001-03-28 [17P] REQUEST FOR EXAMINATION FILED

- Ref Legal Event Code: 17P

- Effective date: 20001227

2001-03-28 [AK] DESIGNATED CONTRACTING STATES:

- Ref Legal Event Code: AK

- Designated State(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE