EP 1085881 A1 20010328 - PHARMACEUTICAL COMPOSITIONS CONTAINING ALPHA-TOCOPHERYLPHOSPHOCHOLINE
Title (en)
PHARMACEUTICAL COMPOSITIONS CONTAINING ALPHA-TOCOPHERYLPHOSPHOCHOLINE
Title (de)
PHARMAZEUTISCHE ZUSAMMENSETZUNGEN ENTHALTEND ALPHA-TOCOPHERYLPHOSPHOCHOLIN
Title (fr)
COMPOSITIONS PHARMACEUTIQUES CONTENANT DE L'ALPHA-TOCOPHERYLPHOSPHOCHOLINE
Publication
Application
Priority
US 9811818 W 19980608
Abstract (en)
[origin: WO9964015A1] alpha -Tocopherylphosphocholine and salts thereof have been discovered to possess antiviral, anti-fungal, anti-inflammatory, PAF-antagonist, and ultra-violet radiation-blocking activities. The compounds are effective to treat a variety of ailments, including diseases of the airways and pulmonary passages. The compound and salts have also been discovered to be capable of forming liposomes. The present invention thus provides methods of treating viral and fungal infections, respiratory disorders, inflammatory disorders and pathophysiological conditions due to PAF activity in a mammal by administering to the mammal alpha -tocopherylphosphocholine or a pharmaceutically acceptable salt thereof. The invention also provides pharmaceutical compositions comprising alpha -tocopherylphosphocholine or a pharmaceutically acceptable salt thereof and a pharmaceutically acceptable carrier. Further, the invention provides liposomes which comprise alpha -tocopherylphosphocholine or a salt thereof as a structural component of the liposome bilayer.
[origin: WO9964015A1] alpha -Tocopherylphosphocholine and salts thereof have been discovered to possess antiviral, anti-fungal, anti-inflammatory, PAF-antagonist, and ultra-violet radiation-blocking activities. The compounds are effective to treat a variety of ailments, including diseases of the airways and pulmonary passages. The compound and salts have also been discovered to be capable of forming liposomes. The present invention thus provides methods of treating viral and fungal infections, respiratory disorders, inflammatory disorders and pathophysiological conditions due to PAF activity in a mammal by administering to the mammal alpha -tocopherylphosphocholine or a pharmaceutically acceptable salt thereof. The invention also provides pharmaceutical compositions comprising alpha -tocopherylphosphocholine or a pharmaceutically acceptable salt thereof and a pharmaceutically acceptable carrier. Further, the invention provides liposomes which comprise alpha -tocopherylphosphocholine or a salt thereof as a structural component of the liposome bilayer.
IPC 1-7
IPC 8 full level
A61K 31/665 (2006.01)
CPC (source: EP)
A61K 31/665 (2013.01); A61K 31/685 (2013.01)
Citation (search report)
See references of WO 9964015A1
Designated contracting state (EPC)
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
DOCDB simple family (publication)
WO 9964015 A1 19991216; AU 7826198 A 19991230; CA 2334313 A1 19991216; EP 1085881 A1 20010328
DOCDB simple family (application)
US 9811818 W 19980608; AU 7826198 A 19980608; CA 2334313 A 19980608; EP 98926417 A 19980608