Global patent index - EP 1085888 A1

EP 1085888 A1 2001-03-28 - MULTIVALENT AGONISTS, PARTIAL AGONISTS, INVERSE AGONISTS AND ANTAGONISTS OF THE 5-HT 3? RECEPTORS

Title (en)

MULTIVALENT AGONISTS, PARTIAL AGONISTS, INVERSE AGONISTS AND ANTAGONISTS OF THE 5-HT 3? RECEPTORS

Title (de)

MULTIVALENTE AGONISTEN, PARTIELLE ANTAGONISTEN, INVERSE AGONISTEN UND ANTAGONISTEN DES 5-HT 3-REZEPTORS

Title (fr)

AGONISTES POLYVALENTS, AGONISTES PARTIELS, AGONISTES INVERSES ET ANTAGONISTES DES RECEPTEURS 5-HT 3?

Publication

EP 1085888 A1 (EN)

Application

EP 99928450 A

Priority

  • US 9912768 W
  • US 8846698 P
  • US 9293898 P
  • US 12028299 P

Abstract (en)

[origin: WO9964046A1] Disclosed are novel multi-binding compounds (agents) which bind 5-HT3 receptors. The compounds of this invention comprise a plurality of ligands each of which can bind to such receptors thereby modulating the biological processes/functions thereof. Each of the ligands is covalently attached to a linker or linkers which may be the same or different to provide for the multi-binding compound. The linker is selected such that the multi-binding compound so constructed demonstrates increased modulation of the biological processes mediated by the 5-HT3 receptor.

IPC 1-7 (main, further and additional classification)

A61K 38/00; A61K 39/00; A61K 39/395; A61K 39/44; A61K 51/00; C07K 2/00; C07K 4/00; G01N 33/53; G01N 33/543; G01N 33/566

IPC 8 full level (invention and additional information)

A61K 31/00 (2006.01); A61K 38/00 (2006.01); A61K 39/00 (2006.01); A61K 39/395 (2006.01); A61K 39/44 (2006.01); A61K 51/00 (2006.01); C07K 2/00 (2006.01); C07K 4/00 (2006.01); G01N 33/53 (2006.01); G01N 33/543 (2006.01); G01N 33/566 (2006.01)

CPC (invention and additional information)

A61K 31/00 (2013.01); A61K 38/00 (2013.01); A61K 39/00 (2013.01); A61K 39/395 (2013.01); A61K 39/44 (2013.01); A61K 51/00 (2013.01); C07K 2/00 (2013.01); C07K 4/00 (2013.01); G01N 33/53 (2013.01); G01N 33/543 (2013.01); G01N 33/566 (2013.01)

Citation (search report)

See references of WO 9964046A1

Designated contracting state (EPC)

AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

EPO simple patent family

WO 9964046 A1 19991216; WO 9964046 A8 20010816; WO 9964046 A9 20000420; AU 4551499 A 19991230; CA 2321191 A1 19991216; EP 1085888 A1 20010328

INPADOC legal status

2003-07-23 [18D] DEEMED TO BE WITHDRAWN

- Ref Legal Event Code: 18D

- Effective date: 20030103

2001-03-28 [17P] REQUEST FOR EXAMINATION FILED

- Ref Legal Event Code: 17P

- Effective date: 20010108

2001-03-28 [AK] DESIGNATED CONTRACTING STATES:

- Ref Legal Event Code: AK

- Designated State(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE