EP 1085892 A2 20010328 - VACCINATION STRATEGY TO PREVENT AND TREAT CANCERS
Title (en)
VACCINATION STRATEGY TO PREVENT AND TREAT CANCERS
Title (de)
IMPFSTRATEGIE ZUR VORBEUGUNG UND BEHANDLUNG VON KREBS
Title (fr)
STRATEGIE DE VACCINATION PERMETTANT DE PREVENIR ET DE TRAITER LES CANCERS
Publication
Application
Priority
- US 9913146 W 19990611
- US 8905598 P 19980612
- US 10633998 P 19981030
Abstract (en)
[origin: WO9963945A2] A cellular immune response is induced to a non-immunogenic or weakly immunogenic target protein expressed by tumor cells, by administering to a mammalian subject an amount of a therapeutic antigen effective to induce a cellular immune response to the target protein. The therapeutic antigen is an immunogenic peptide having an MHC-binding portion which binds to the major histocompatibility complex (MHC) and an immune-recognition portion which is recognized by T-cells. The therapeutic antigen is derived from the non-immunogenic or weakly immunogenic target protein such that the MHC-binding portion binds to MHC with a greater affinity than the target protein without material alteration of the immune-recognition portion. The therapeutic antigen may include a sorting signal which directs the transport of the therapeutic antigen into the endoplasmic reticulum and into the endosome/lysosome to facilitate loading of the peptide onto MHC class I and class II molecules, respectively, to facilitate loading of the protein onto MHC molecules for presentation to the immune system.
IPC 1-7
IPC 8 full level
A61K 39/00 (2006.01); A61P 35/00 (2006.01)
CPC (source: EP US)
A61K 39/0011 (2013.01 - EP US); A61K 39/001124 (2018.08 - EP US); A61K 39/001157 (2018.08 - EP US); A61K 39/001195 (2018.08 - EP US); A61P 35/00 (2018.01 - EP)
Designated contracting state (EPC)
BE CH DE DK FR GB IE LI NL SE
DOCDB simple family (publication)
WO 9963945 A2 19991216; WO 9963945 A3 20000302; CA 2331378 A1 19991216; EP 1085892 A2 20010328; EP 1085892 A4 20020717
DOCDB simple family (application)
US 9913146 W 19990611; CA 2331378 A 19990611; EP 99930206 A 19990611