Global Patent Index - EP 1085892 A2

EP 1085892 A2 2001-03-28 - VACCINATION STRATEGY TO PREVENT AND TREAT CANCERS

Title (en)

VACCINATION STRATEGY TO PREVENT AND TREAT CANCERS

Title (de)

IMPFSTRATEGIE ZUR VORBEUGUNG UND BEHANDLUNG VON KREBS

Title (fr)

STRATEGIE DE VACCINATION PERMETTANT DE PREVENIR ET DE TRAITER LES CANCERS

Publication

EP 1085892 A2 (EN)

Application

EP 99930206 A

Priority

  • US 9913146 W
  • US 8905598 P
  • US 10633998 P

Abstract (en)

[origin: WO9963945A2] A cellular immune response is induced to a non-immunogenic or weakly immunogenic target protein expressed by tumor cells, by administering to a mammalian subject an amount of a therapeutic antigen effective to induce a cellular immune response to the target protein. The therapeutic antigen is an immunogenic peptide having an MHC-binding portion which binds to the major histocompatibility complex (MHC) and an immune-recognition portion which is recognized by T-cells. The therapeutic antigen is derived from the non-immunogenic or weakly immunogenic target protein such that the MHC-binding portion binds to MHC with a greater affinity than the target protein without material alteration of the immune-recognition portion. The therapeutic antigen may include a sorting signal which directs the transport of the therapeutic antigen into the endoplasmic reticulum and into the endosome/lysosome to facilitate loading of the peptide onto MHC class I and class II molecules, respectively, to facilitate loading of the protein onto MHC molecules for presentation to the immune system.

IPC 1-7 (main, further and additional classification)

A61K 38/00; A61K 38/04; A61K 38/08; A61K 38/10

IPC 8 full level (invention and additional information)

A61K 39/00 (2006.01); A61P 35/00 (2006.01)

CPC (invention and additional information)

A61K 39/0011 (2013.01)

Designated contracting state (EPC)

BE CH DE DK FR GB IE LI NL SE

EPO simple patent family

WO 9963945 A2 19991216; WO 9963945 A3 20000302; CA 2331378 A1 19991216; EP 1085892 A2 20010328; EP 1085892 A4 20020717

INPADOC legal status


2006-07-12 [18D] DEEMED TO BE WITHDRAWN

- Effective date: 20060118

2004-03-10 [17Q] FIRST EXAMINATION REPORT

- Effective date: 20040123

2002-07-17 [A4] SUPPLEMENTARY SEARCH REPORT

- Effective date: 20020604

2002-07-17 [AK] DESIGNATED CONTRACTING STATES:

- Kind Code of Ref Document: A4

- Designated State(s): BE CH DE DK FR GB IE LI NL SE

2001-03-28 [17P] REQUEST FOR EXAMINATION FILED

- Effective date: 20010110

2001-03-28 [AK] DESIGNATED CONTRACTING STATES:

- Kind Code of Ref Document: A2

- Designated State(s): BE CH DE DK FR GB IE LI NL SE