EP 1086063 A4 20010328 - NOVEL POTASSIUM CHANNEL DRUGS AND THEIR USES
Title (en)
NOVEL POTASSIUM CHANNEL DRUGS AND THEIR USES
Title (de)
KALIUMKANAL WIRKSTOFFE UND DEREN VERWENDUNG
Title (fr)
MEDICAMENTS A CANAL POTASSIUM ET LEUR UTILISATION
Publication
Application
Priority
- US 9912777 W 19990607
- US 8846598 P 19980608
- US 9306898 P 19980716
- US 11386498 P 19981224
Abstract (en)
[origin: WO9964050A1] This invention relates to novel multibinding compounds that bind to potassium (K<+>) channels and modulate their activity. The compounds of this invention comprise 2-10 K<+> channel ligands covalently connected by a linker or linkers, wherein the ligands in their monovalent (i.e., unlinked) state bind to one or more types of K<+> channel. The manner of linking the ligands together is such that the multibinding agents thus formed demonstrate an increased biologic and/or therapeutic effect as compared to the same number of unlinked ligands made available for binding to the K<+> channel. The invention also relates to methods of using such compounds and to methods of preparing them. The compounds of this invention are particularly useful for treating diseases and conditions of mammals that are mediated by K<+> channels. Accordingly, this invention also relates to pharmaceutical compositions comprising a pharmaceutically acceptable excipient and an effective amount of a compound of this invention.
IPC 1-7
C07B 61/00; A61K 38/00; A61K 39/00; A61K 39/44; A61K 39/395; A61K 51/00; G01N 33/53; G01N 33/543; G01N 33/566
IPC 8 full level
A61K 9/06 (2006.01); A61K 31/18 (2006.01); A61K 31/343 (2006.01); A61K 31/395 (2006.01); A61K 31/407 (2006.01); A61K 31/4178 (2006.01); A61K 31/4427 (2006.01); A61K 31/443 (2006.01); A61K 31/4545 (2006.01); A61K 45/00 (2006.01); A61K 47/48 (2006.01); A61P 9/00 (2006.01); A61P 43/00 (2006.01); C07C 311/08 (2006.01); C07C 311/10 (2006.01); C07C 311/12 (2006.01); C07C 311/22 (2006.01); C07C 311/30 (2006.01); C07D 257/02 (2006.01); C07D 307/80 (2006.01); C07D 401/06 (2006.01); C07D 405/12 (2006.01); C07D 487/04 (2006.01); C07D 487/08 (2006.01); C07K 5/09 (2006.01); C07K 5/11 (2006.01); C07K 7/06 (2006.01); C07K 7/08 (2006.01); G01N 33/15 (2006.01); G01N 33/50 (2006.01); G01N 33/566 (2006.01); G01N 33/68 (2006.01)
CPC (source: EP)
A61K 47/55 (2017.07); A61K 47/65 (2017.07); A61P 9/00 (2017.12); A61P 9/06 (2017.12); A61P 43/00 (2017.12); G01N 33/6872 (2013.01)
Citation (search report)
- [A] GUO, WEINONG ET AL: "Evidences of antagonism between amiodarone and triiodothyronine on the K+ channel activities of cultured rat cardiomyocytes", J. MOL. CELL. CARDIOL. (1997), 29(2), 617-627, XP000922930
- See references of WO 9964050A1
Designated contracting state (EPC)
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
DOCDB simple family (publication)
WO 9964050 A1 19991216; WO 9964050 A8 20000224; WO 9964050 A9 20000420; AR 015310 A1 20010418; AU 4426499 A 19991230; CA 2318745 A1 19991216; EP 1086063 A1 20010328; EP 1086063 A4 20010328; JP 2002517466 A 20020618; SG 80037 A1 20010417
DOCDB simple family (application)
US 9912777 W 19990607; AR P990102703 A 19990608; AU 4426499 A 19990607; CA 2318745 A 19990607; EP 99927330 A 19990607; JP 2000553118 A 19990607; SG 1999002714 A 19990608