Global Patent Index - EP 1086066 A4

EP 1086066 A4 20010808 - MUSCARINIC RECEPTOR ANTAGONISTS

Title (en)

MUSCARINIC RECEPTOR ANTAGONISTS

Title (de)

MUSKARINREZEPTORANTAGONISTEN

Title (fr)

ANTAGONISTES DES RECEPTEURS MUSCARINIQUES

Publication

EP 1086066 A4 20010808 (EN)

Application

EP 99928444 A 19990607

Priority

  • US 9912733 W 19990607
  • US 8846698 P 19980608
  • US 9293898 P 19980715
  • US 12028799 P 19990216

Abstract (en)

[origin: WO9964043A1] Disclosed are multibinding compounds which are muscarinic receptor antagonists. The multibinding compounds of this invention containing from 2 to 10 ligands covalently attached to one or more linkers. Each ligand is, independently of each other, a muscarinic receptor antagonist or an allosteric modulator provided that at least one of said ligand is a muscarinic receptor antagonist. The multibinding compounds of this invention are useful in the treatment and prevention of diseases such as chronic obstructive pulmonary disease, chronic bronchitis, irritable bowel syndrome, urinary incontinence, and the like.

IPC 1-7

C07B 61/00; A61K 38/00; A61K 39/00; A61K 39/44; A61K 39/395; A61K 51/00; G01N 33/53; G01N 33/543; G01N 33/566; C07D 209/00; C07D 211/00; C07D 221/24

IPC 8 full level

A01N 43/00 (2006.01); A01N 55/02 (2006.01); A61K 31/135 (2006.01); A61K 31/33 (2006.01); A61K 31/40 (2006.01); A61K 31/404 (2006.01); A61K 31/44 (2006.01); A61K 31/4427 (2006.01); A61K 31/4439 (2006.01); A61K 31/445 (2006.01); A61K 31/45 (2006.01); A61K 31/4523 (2006.01); A61K 31/454 (2006.01); A61K 31/4545 (2006.01); A61K 31/455 (2006.01); A61K 31/498 (2006.01); A61K 38/00 (2006.01); A61K 38/16 (2006.01); A61K 39/00 (2006.01); A61K 39/395 (2006.01); A61K 39/44 (2006.01); A61K 51/00 (2006.01); A61P 1/04 (2006.01); A61P 1/06 (2006.01); A61P 11/00 (2006.01); A61P 11/06 (2006.01); A61P 13/00 (2006.01); A61P 43/00 (2006.01); C07B 61/00 (2006.01); C07C 217/10 (2006.01); C07D 207/08 (2006.01); C07D 209/00 (2006.01); C07D 209/32 (2006.01); C07D 209/48 (2006.01); C07D 211/00 (2006.01); C07D 211/44 (2006.01); C07D 211/46 (2006.01); C07D 221/24 (2006.01); C07D 401/06 (2006.01); C07D 401/12 (2006.01); C07D 401/14 (2006.01); C07D 403/06 (2006.01); C07D 451/00 (2006.01); C07D 451/06 (2006.01); C07D 451/10 (2006.01); C07D 487/18 (2006.01); C07K 2/00 (2006.01); C07K 4/00 (2006.01); C07K 5/02 (2006.01); C40B 20/00 (2006.01); C40B 40/02 (2006.01); C40B 40/04 (2006.01); C40B 50/06 (2006.01); C40B 60/10 (2006.01); G01N 33/53 (2006.01); G01N 33/543 (2006.01); G01N 33/566 (2006.01)

CPC (source: EP)

A61P 1/00 (2017.12); A61P 1/04 (2017.12); A61P 1/06 (2017.12); A61P 11/00 (2017.12); A61P 11/06 (2017.12); A61P 13/00 (2017.12); A61P 43/00 (2017.12); C07D 209/32 (2013.01); C07D 211/12 (2013.01); C07D 211/44 (2013.01); C07D 401/12 (2013.01); C07D 401/14 (2013.01); C07D 403/06 (2013.01); C07D 403/12 (2013.01)

Citation (search report)

  • [A] ISHIHARA, YUJI ET AL: "Central cholinergic agents. III. Synthesis of 2-alkoxy-2,8- diazaspiro[4.5]decane-1,3-diones as muscarinic agonists", CHEM. PHARM. BULL. (1992), 40(5), 1177-85, XP000651676
  • [A] WEINER, BEN ZION ET AL: "Atropine attached to polyethylene glycols", EUR. J. MED. CHEM. - CHIM. THER. (1976), 11(6), 525-6, XP002140747
  • [A] BACHRACH, A. ET AL: "Attachment of drugs to polydimethylsiloxanes", EUR. POLYM. J. (1984), 20(5), 493-500, XP000196583
  • [A] KOSTENIS, E. ET AL: "Allosteric effect on muscarinic M2-receptors of derivatives of the alkane-bis-ammonium compound W84. Comparison with bispyridinium-type allosteric modulators", EUR. J. MED. CHEM. (1994), 29(12), 947-53, XP002168881
  • [A] DATABASE CHEMABS [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; TOMIOKA, TATSUO: "Synthesis of hypotensive compounds. I. Synthesis of methoxy and ethoxycarbonyloxy benzoates", XP002168883, retrieved from STN Database accession no. 73:120260 & YAKUGAKU ZASSHI (1970), 90(8), 1048-51
  • [A] CHEMICAL ABSTRACTS, vol. 84, no. 7, 16 February 1976, Columbus, Ohio, US; abstract no. 43492, BRAUDE, M. B. ET AL: "Chemical structure and anthelmintic activity. V. Analogs of the anthelmintics neftamon and difezil" XP002168882 & KHIM.-FARM. ZH. (1975), 9(10), 12-14
  • See references of WO 9964043A1

Designated contracting state (EPC)

AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

DOCDB simple family (publication)

WO 9964043 A1 19991216; WO 9964043 A9 20000302; AR 018629 A1 20011128; AU 4550899 A 19991230; AU 763638 B2 20030731; CA 2315883 A1 19991216; EP 1086066 A1 20010328; EP 1086066 A4 20010808; JP 2002517464 A 20020618; NZ 505329 A 20030530; SG 80041 A1 20010417

DOCDB simple family (application)

US 9912733 W 19990607; AR P990102700 A 19990608; AU 4550899 A 19990607; CA 2315883 A 19990607; EP 99928444 A 19990607; JP 2000553111 A 19990607; NZ 50532999 A 19990607; SG 1999002762 A 19990607