Global patent index - EP 1086100 A1

EP 1086100 A1 2001-03-28 - PYRROLE DERIVATIVES, PREPARATION METHOD AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME

Title (en)

PYRROLE DERIVATIVES, PREPARATION METHOD AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME

Title (de)

PYRROLDERIVATE, IHRE HERSTELLUNG UND DIESE ENTHALTENDE PHARMAZEUTISCHE ZUBEREITUNGEN

Title (fr)

DERIVES DU PYRROLE, LEUR PREPARATION ET LES COMPOSITIONS PHARMACEUTIQUES QUI LES CONTIENNENT

Publication

EP 1086100 A1 (FR)

Application

EP 99923678 A

Priority

  • FR 9901330 W
  • FR 9807274 A

Abstract (en)

[origin: FR2779724A1] The invention concerns pyrrole derivatives of general formula (I) wherein: R1 is CONH2, CN, carboxy, alkyloxycarbonyl, or acyl; R2 is a H atom, a halogen atom, a CN, alkyl, alkyoxy, alkenyl or trihalogenomethyl radical; R3 is a H atom or a halogen atom, or an alkyl or OH radical; Het is pyridyl, pyridyl N-oxide or thiazolyl; R4 is a H atom or a halogen atom, an alkylthio or alkyloxy radical; and R5 is a H atom, or a hydroxy or alkyloxy radical; provided that when R3, R4 and R5 are H atoms and Het is a pyridin-2-yl radical, then R1 cannot be acetyl or methyloxycarbonyl and R2 is a H atom, or R1 cannot be propionyl and R2 methyl, the C1-C4 alkyl and C2-C4 alkenyl radicals being linear or branched, as the case may be in the form of stereoisomers or their mixtures and/or their salts when they exist. Said derivatives are particularly useful for treating and preventing diseases wherein are involved herpes family viruses and/or wherein are involved cytokines including TNF alpha .

IPC 1-7 (main, further and additional classification)

C07D 471/04; A61K 31/435

IPC 8 full level (invention and additional information)

A61K 31/444 (2006.01); A61P 31/22 (2006.01); A61P 43/00 (2006.01); C07D 471/04 (2006.01)

CPC (invention and additional information)

C07D 471/04 (2013.01)

Citation (search report)

See references of WO 9964419A1

Designated contracting state (EPC)

AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU NL PT SE

EPO simple patent family

FR 2779724 A1 19991217; FR 2779724 B1 20010420; AU 4045899 A 19991230; EP 1086100 A1 20010328; JP 2002517499 A 20020618; US 2002006380 A1 20020117; WO 9964419 A1 19991216

INPADOC legal status

2002-04-03 [18D] DEEMED TO BE WITHDRAWN

- Ref Legal Event Code: 18D

- Effective date: 20010925

2001-06-27 [17Q] FIRST EXAMINATION REPORT

- Ref Legal Event Code: 17Q

- Effective date: 20010514

2001-03-28 [17P] REQUEST FOR EXAMINATION FILED

- Ref Legal Event Code: 17P

- Effective date: 20001204

2001-03-28 [AK] DESIGNATED CONTRACTING STATES:

- Ref Legal Event Code: AK

- Designated State(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU NL PT SE