EP 1086120 A1 20010328 - METHOD FOR PREPARING OF VIRUS-SAFE INTERFERON COMPOSITIONS
Title (en)
METHOD FOR PREPARING OF VIRUS-SAFE INTERFERON COMPOSITIONS
Title (de)
VERFAHREN ZUR HERSTELLUNG VIRUSSICHERER INTERFERON-ZUBEREITUNGEN
Title (fr)
PROCEDE DE PREPARATION DE COMPOSITIONS D'INTERFERON EXEMPTES DE VIRUS
Publication
Application
Priority
- FI 9900505 W 19990609
- FI 981337 A 19980610
Abstract (en)
[origin: WO9964441A1] The present invention concerns a method of preparing pharmaceutical compositions of a biologically active proteins, in particular multicomponent interferon compositions. The invention comprises the steps of adding to a solution of the protein a non-ionic detergent in an efficient amount to provide an extended shelf-life of the pharmaceutical composition; subjecting the solution containing the non-ionic detergent to filtration on a virus removal filter with a pore size of 10 to 40 nm; and recovering the filtrate. The method gives rise to, e.g., a virus-safe multicomponent alpha -interferon composition, comprising a non-ionic detergent as a stabilizer in an amount exceeding the critical micellar concentration of the detergent and being essentially free from substances retained on a virus-filter having high virus retentive capacity.
IPC 1-7
IPC 8 full level
A61K 9/00 (2006.01); A61K 38/21 (2006.01); A61K 47/26 (2006.01); A61L 2/00 (2006.01); C07K 1/34 (2006.01); C07K 14/56 (2006.01); C12P 21/02 (2006.01)
CPC (source: EP)
A61K 9/0019 (2013.01); A61K 38/212 (2013.01); A61K 47/26 (2013.01); A61L 2/0017 (2013.01); C07K 1/34 (2013.01); C07K 14/56 (2013.01); C12P 21/02 (2013.01)
Citation (search report)
See references of WO 9964441A1
Designated contracting state (EPC)
AT CH DE ES FR GB LI NL SE
DOCDB simple family (publication)
WO 9964441 A1 19991216; AU 4783499 A 19991230; EP 1086120 A1 20010328; FI 106465 B 20010215; FI 981337 A0 19980610; FI 981337 A 19991211
DOCDB simple family (application)
FI 9900505 W 19990609; AU 4783499 A 19990609; EP 99931279 A 19990609; FI 981337 A 19980610