Global patent index - EP 1086120 A1

EP 1086120 A1 2001-03-28 - METHOD FOR PREPARING OF VIRUS-SAFE INTERFERON COMPOSITIONS

Title (en)

METHOD FOR PREPARING OF VIRUS-SAFE INTERFERON COMPOSITIONS

Title (de)

VERFAHREN ZUR HERSTELLUNG VIRUSSICHERER INTERFERON-ZUBEREITUNGEN

Title (fr)

PROCEDE DE PREPARATION DE COMPOSITIONS D'INTERFERON EXEMPTES DE VIRUS

Publication

EP 1086120 A1 (EN)

Application

EP 99931279 A

Priority

  • FI 9900505 W
  • FI 981337 A

Abstract (en)

[origin: WO9964441A1] The present invention concerns a method of preparing pharmaceutical compositions of a biologically active proteins, in particular multicomponent interferon compositions. The invention comprises the steps of adding to a solution of the protein a non-ionic detergent in an efficient amount to provide an extended shelf-life of the pharmaceutical composition; subjecting the solution containing the non-ionic detergent to filtration on a virus removal filter with a pore size of 10 to 40 nm; and recovering the filtrate. The method gives rise to, e.g., a virus-safe multicomponent alpha -interferon composition, comprising a non-ionic detergent as a stabilizer in an amount exceeding the critical micellar concentration of the detergent and being essentially free from substances retained on a virus-filter having high virus retentive capacity.

IPC 1-7 (main, further and additional classification)

C07K 1/34; C07K 14/54

IPC 8 full level (invention and additional information)

A61K 9/00 (2006.01); A61K 38/21 (2006.01); A61K 47/26 (2006.01); A61L 2/00 (2006.01); C07K 1/34 (2006.01); C07K 14/56 (2006.01); C12P 21/02 (2006.01)

CPC (invention and additional information)

C12P 21/02 (2013.01); A61K 9/0019 (2013.01); A61K 38/212 (2013.01); A61K 47/26 (2013.01); A61L 2/0017 (2013.01); C07K 1/34 (2013.01); C07K 14/56 (2013.01)

Citation (search report)

See references of WO 9964441A1

Designated contracting state (EPC)

AT CH DE ES FR GB LI NL SE

EPO simple patent family

WO 9964441 A1 19991216; AU 4783499 A 19991230; EP 1086120 A1 20010328; FI 106465 B 20010215; FI 981337 A0 19980610; FI 981337 A 19991211

INPADOC legal status

2004-08-18 [18D] DEEMED TO BE WITHDRAWN

- Ref Legal Event Code: 18D

- Effective date: 20040211

2003-10-22 [RIC1] CLASSIFICATION (CORRECTION)

- Ref Legal Event Code: RIC1

- IPC: 7C 07K 1/34 A

2003-10-22 [RIC1] CLASSIFICATION (CORRECTION)

- Ref Legal Event Code: RIC1

- IPC: 7C 07K 14/54 B

2003-10-22 [RTI1] TITLE (CORRECTION)

- Ref Legal Event Code: RTI1

- Free Format Text: METHOD FOR PREPARING OF VIRUS-SAFE INTERFERON COMPOSITIONS

2001-08-01 [17Q] FIRST EXAMINATION REPORT

- Ref Legal Event Code: 17Q

- Effective date: 20010619

2001-03-28 [17P] REQUEST FOR EXAMINATION FILED

- Ref Legal Event Code: 17P

- Effective date: 20001108

2001-03-28 [AK] DESIGNATED CONTRACTING STATES:

- Ref Legal Event Code: AK

- Designated State(s): AT CH DE ES FR GB LI NL SE