Global Patent Index - EP 1086238 A1

EP 1086238 A1 2001-03-28 - HUMAN MP52 GENE PROMOTER AND METHOD FOR EXPLORING USEFUL SUBSTANCE BY USING THE SAME

Title (en)

HUMAN MP52 GENE PROMOTER AND METHOD FOR EXPLORING USEFUL SUBSTANCE BY USING THE SAME

Title (de)

PROMOTOR DES MENSCHLICHES MP52 GENS UND DESSEN ANWENDUNG ZUR UNTERSUCHUNG NUTZBARER SUBSTANZEN

Title (fr)

PROMOTEUR DU GENE HUMAIN MP52 ET PROCEDE L'ASSOCIANT DANS LA RECHERCHE DE SUBSTANCES UTILES

Publication

EP 1086238 A1 (EN)

Application

EP 99923787 A

Priority

  • IB 9901071 W
  • JP 17094198 A

Abstract (en)

[origin: WO9966060A1] The present object is to provide a method for exploring low molecular weight compounds having osteogenetic activity or an activity to inhibit osteogenesis that shows an equal degree to human BMP proteins. A method for exploring low molecular weight compounds which regulate positively or negatively the expression of human MP52 with reference to a reporter acivity by using 5' upstream region gene containing the human MP52 promoter and an animal cell into which a recombinant expression vector that has been ligated to an appropriate reporter gene has been introduced. Low molecular weight compounds and their derivatives obtained by the present method have morphogenetic activity and inhibiting activity for bone and cartilage, inducing or inhibiting activity for tendon and ligament, forming, inducing, and protecting effects on neural cells, or inducing or inhibiting angiogenic activity, and are effective as preventive or therapeutic agent for cartilage and bone diseases, therapeutic agent for injury of tendon and ligament, therapeutic agent for neural diseases, or healing agent for injury and carcinostatic, through the expression of human MP52.

IPC 1-7 (main, further and additional classification)

C12N 15/85; C12Q 1/68

IPC 8 full level (invention and additional information)

G01N 33/50 (2006.01); A61K 45/00 (2006.01); A61P 43/00 (2006.01); C12N 5/00 (2006.01); C12N 5/10 (2006.01); C12N 15/00 (2006.01); C12N 15/09 (2006.01); C12N 15/85 (2006.01); C12Q 1/68 (2006.01); G01N 33/15 (2006.01); G01N 33/566 (2006.01); C12R 1/91 (2006.01)

CPC (invention and additional information)

C12N 15/85 (2013.01); C12N 2830/00 (2013.01); C12N 2830/85 (2013.01)

Citation (search report)

See references of WO 9966060A1

Designated contracting state (EPC)

AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU NL PT SE

EPO simple patent family

WO 9966060 A1 19991223; AU 4054299 A 20000105; EP 1086238 A1 20010328; JP 2000004882 A 20000111; JP 2002518019 A 20020625

INPADOC legal status


2005-06-29 [18R] REFUSED

- Ref Legal Event Code: 18R

- Effective date: 20041222

2003-08-13 [17Q] FIRST EXAMINATION REPORT

- Ref Legal Event Code: 17Q

- Effective date: 20030701

2002-09-11 [RAP1] TRANSFER OF RIGHTS OF AN EP PUBLISHED APPLICATION

- Owner name: BIOPHARM GESELLSCHAFT ZUR BIOTECHNOLOGISCHEN ENTWI

- Ref Legal Event Code: RAP1

2001-03-28 [17P] REQUEST FOR EXAMINATION FILED

- Ref Legal Event Code: 17P

- Effective date: 20010118

2001-03-28 [AK] DESIGNATED CONTRACTING STATES:

- Ref Legal Event Code: AK

- Designated State(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU NL PT SE