Global Patent Index - EP 1087954 A1

EP 1087954 A1 20010404 - CYCLOALKYL-SUBSTITUTED ARYL-PIPERAZINES, PIPERIDINES AND TETRAHYDROPYRIDINES AS SEROTONERGIC AGENTS

Title (en)

CYCLOALKYL-SUBSTITUTED ARYL-PIPERAZINES, PIPERIDINES AND TETRAHYDROPYRIDINES AS SEROTONERGIC AGENTS

Title (de)

CYCLOALKYL-SUBSTITUIERTTE ARYL-PIPERAZINE, PIPERIDINE UND TETRAHYDROPYRIDINE ALS SEROTONERGISCHE AGENTE

Title (fr)

TETRAHYDROPYRIDINES, PIPERIDINES ET ARYL-PIPERAZINES A SUBSTITUTION CYCLOALKYLE, UTILISES EN TANT QU'AGENTS SEROTONINERGIQUES

Publication

EP 1087954 A1 20010404 (EN)

Application

EP 99928648 A 19990614

Priority

  • US 9913397 W 19990614
  • US 9746398 A 19980615

Abstract (en)

[origin: WO9965887A1] This invention relates to compounds which have activity as 5-HT1A agonists and antagonists which may be useful for the treatment of anxiety, depression, cognitive deficits, and prostate cancer. Useful compounds are those of formula (I) where: X is selected from the group consisting of (1), (2), (3); n is selected from the integers 1 through 5; R<1> is optionally substituted C6-C10-aryl or mono or bicyclic heteroaryl, with a proviso that heteroaryl is not thiadiazole; R<2> is selected from the group consisting of H and C1-C6 alkyl; R<3> is selected from the group consisting of H, COR<5>, COOR<5>, and CONR<5>R<6>; R<4>, R<5> and R<6> are as defined hereinabove; or an optical isomer; or a pharmaceutically acceptable salt thereof.

IPC 1-7

C07D 295/12; C07D 319/18; C07D 209/08; A61K 31/495

IPC 8 full level

A61K 31/4418 (2006.01); A61K 31/445 (2006.01); A61K 31/495 (2006.01); A61K 31/496 (2006.01); A61P 1/08 (2006.01); A61P 13/08 (2006.01); A61P 25/22 (2006.01); A61P 25/24 (2006.01); A61P 25/28 (2006.01); A61P 35/00 (2006.01); A61P 43/00 (2006.01); C07D 209/08 (2006.01); C07D 211/22 (2006.01); C07D 211/70 (2006.01); C07D 295/12 (2006.01); C07D 295/13 (2006.01); C07D 319/18 (2006.01)

CPC (source: EP)

A61P 1/08 (2017.12); A61P 13/08 (2017.12); A61P 25/22 (2017.12); A61P 25/24 (2017.12); A61P 25/28 (2017.12); A61P 35/00 (2017.12); A61P 43/00 (2017.12); C07D 209/08 (2013.01); C07D 211/22 (2013.01); C07D 295/13 (2013.01); C07D 319/18 (2013.01)

Citation (search report)

See references of WO 9965887A1

Designated contracting state (EPC)

AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU NL PT SE

DOCDB simple family (publication)

WO 9965887 A1 19991223; AU 4566399 A 20000105; BR 9911280 A 20010313; CA 2334254 A1 19991223; CN 1312802 A 20010912; EP 1087954 A1 20010404; JP 2002518382 A 20020625

DOCDB simple family (application)

US 9913397 W 19990614; AU 4566399 A 19990614; BR 9911280 A 19990614; CA 2334254 A 19990614; CN 99809567 A 19990614; EP 99928648 A 19990614; JP 2000554713 A 19990614