Global Patent Index - EP 1087954 A1

EP 1087954 A1 2001-04-04 - CYCLOALKYL-SUBSTITUTED ARYL-PIPERAZINES, PIPERIDINES AND TETRAHYDROPYRIDINES AS SEROTONERGIC AGENTS

Title (en)

CYCLOALKYL-SUBSTITUTED ARYL-PIPERAZINES, PIPERIDINES AND TETRAHYDROPYRIDINES AS SEROTONERGIC AGENTS

Title (de)

CYCLOALKYL-SUBSTITUIERTTE ARYL-PIPERAZINE, PIPERIDINE UND TETRAHYDROPYRIDINE ALS SEROTONERGISCHE AGENTE

Title (fr)

TETRAHYDROPYRIDINES, PIPERIDINES ET ARYL-PIPERAZINES A SUBSTITUTION CYCLOALKYLE, UTILISES EN TANT QU'AGENTS SEROTONINERGIQUES

Publication

EP 1087954 A1 (EN)

Application

EP 99928648 A

Priority

  • US 9913397 W
  • US 9746398 A

Abstract (en)

[origin: WO9965887A1] This invention relates to compounds which have activity as 5-HT1A agonists and antagonists which may be useful for the treatment of anxiety, depression, cognitive deficits, and prostate cancer. Useful compounds are those of formula (I) where: X is selected from the group consisting of (1), (2), (3); n is selected from the integers 1 through 5; R<1> is optionally substituted C6-C10-aryl or mono or bicyclic heteroaryl, with a proviso that heteroaryl is not thiadiazole; R<2> is selected from the group consisting of H and C1-C6 alkyl; R<3> is selected from the group consisting of H, COR<5>, COOR<5>, and CONR<5>R<6>; R<4>, R<5> and R<6> are as defined hereinabove; or an optical isomer; or a pharmaceutically acceptable salt thereof.

IPC 1-7 (main, further and additional classification)

C07D 295/12; A61K 31/495; C07D 209/08; C07D 319/18

IPC 8 full level (invention and additional information)

C07D 295/12 (2006.01); A61K 31/4418 (2006.01); A61K 31/445 (2006.01); A61K 31/495 (2006.01); A61K 31/496 (2006.01); A61P 1/08 (2006.01); A61P 13/08 (2006.01); A61P 25/22 (2006.01); A61P 25/24 (2006.01); A61P 25/28 (2006.01); A61P 35/00 (2006.01); A61P 43/00 (2006.01); C07D 209/08 (2006.01); C07D 211/22 (2006.01); C07D 211/70 (2006.01); C07D 295/13 (2006.01); C07D 319/18 (2006.01)

CPC (invention and additional information)

C07D 295/13 (2013.01); C07D 209/08 (2013.01); C07D 211/22 (2013.01); C07D 319/18 (2013.01)

Citation (search report)

See references of WO 9965887A1

Designated contracting state (EPC)

AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU NL PT SE

EPO simple patent family

WO 9965887 A1 19991223; AU 4566399 A 20000105; BR 9911280 A 20010313; CA 2334254 A1 19991223; CN 1312802 A 20010912; EP 1087954 A1 20010404; JP 2002518382 A 20020625

INPADOC legal status


2006-07-19 [18D] DEEMED TO BE WITHDRAWN

- Effective date: 20060126

2002-06-19 [RAP1] TRANSFER OF RIGHTS OF AN EP PUBLISHED APPLICATION

- Owner name: WYETH

2001-07-11 [17Q] FIRST EXAMINATION REPORT

- Effective date: 20010523

2001-04-04 [17P] REQUEST FOR EXAMINATION FILED

- Effective date: 20001127

2001-04-04 [AK] DESIGNATED CONTRACTING STATES:

- Kind Code of Ref Document: A1

- Designated State(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU NL PT SE

2001-04-04 [AX] REQUEST FOR EXTENSION OF THE EUROPEAN PATENT TO

- Free text: AL PAYMENT 20001127;LT PAYMENT 20001127;LV PAYMENT 20001127;RO PAYMENT 20001127;SI PAYMENT 20001127