Global Patent Index - EP 1087985 A1

EP 1087985 A1 2001-04-04 - EXONS 4 AND 7 ENCODE SEPARATE TRANSACTIVATING AND CHROMATIN LOCALIZING DOMAINS IN ESX

Title (en)

EXONS 4 AND 7 ENCODE SEPARATE TRANSACTIVATING AND CHROMATIN LOCALIZING DOMAINS IN ESX

Title (de)

SEPARATE TRANSAKTIVIERUNGS- UND CHROMATINLOKALISIERUNGS-DOMÄNEN IN ESX DIE EXONE 4 UND 7 KODIEREN

Title (fr)

LES EXONS 4 ET 7 CODENT POUR DES DOMAINES DISTINCTS DE TRANSACTIVATION ET DE LOCALISATION DE LA CHROMOTINE DANS LE FACTEUR ESX

Publication

EP 1087985 A1 (EN)

Application

EP 99928601 A

Priority

  • US 9913277 W
  • US 8940998 P
  • US 28953599 A

Abstract (en)

[origin: WO9965929A1] This invention identified two domains of ESX, a member of the ETS transcription regulator family, that provide particularly effective targets useful in screening for ESX modulators. One of these domains, ESX exon 4 is a potent transactivator and can be used in constructs to up-or downregulate genes or cDNAs, particularly genes or cDNAs under the control of a promoter containing an Ets element. Another of these domains, exon 7, is capable of acetylation and the level of acetylation can be used in assays for abnormal ESX regulation.

IPC 1-7 (main, further and additional classification)

C07H 21/04; C07K 14/435; C12Q 1/68; G01N 33/52

IPC 8 full level (invention and additional information)

C07K 14/47 (2006.01); C07K 14/82 (2006.01); C12Q 1/68 (2006.01); G01N 33/68 (2006.01); A61K 38/00 (2006.01)

CPC (invention and additional information)

B82Y 5/00 (2013.01); B82Y 10/00 (2013.01); C07K 14/4705 (2013.01); C07K 14/82 (2013.01); C12Q 1/6897 (2013.01); G01N 33/6872 (2013.01); A61K 38/00 (2013.01); C07K 2319/00 (2013.01); C12Q 1/6886 (2013.01)

Combination set (CPC)

C12Q 1/6897 + C12Q 2522/101

Citation (search report)

See references of WO 9965929A1

Designated contracting state (EPC)

AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

EPO simple patent family

WO 9965929 A1 19991223; AU 4563599 A 20000105; CA 2331266 A1 19991223; EP 1087985 A1 20010404

INPADOC legal status


2004-08-04 [18D] DEEMED TO BE WITHDRAWN

- Effective date: 20040103

2001-04-04 [17P] REQUEST FOR EXAMINATION FILED

- Effective date: 20010105

2001-04-04 [AK] DESIGNATED CONTRACTING STATES:

- Kind Code of Ref Document: A1

- Designated State(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE