EP 1087985 A1 20010404 - EXONS 4 AND 7 ENCODE SEPARATE TRANSACTIVATING AND CHROMATIN LOCALIZING DOMAINS IN ESX
Title (en)
EXONS 4 AND 7 ENCODE SEPARATE TRANSACTIVATING AND CHROMATIN LOCALIZING DOMAINS IN ESX
Title (de)
SEPARATE TRANSAKTIVIERUNGS- UND CHROMATINLOKALISIERUNGS-DOMÄNEN IN ESX DIE EXONE 4 UND 7 KODIEREN
Title (fr)
LES EXONS 4 ET 7 CODENT POUR DES DOMAINES DISTINCTS DE TRANSACTIVATION ET DE LOCALISATION DE LA CHROMOTINE DANS LE FACTEUR ESX
Publication
Application
Priority
- US 9913277 W 19990615
- US 8940998 P 19980616
- US 28953599 A 19990409
Abstract (en)
[origin: WO9965929A1] This invention identified two domains of ESX, a member of the ETS transcription regulator family, that provide particularly effective targets useful in screening for ESX modulators. One of these domains, ESX exon 4 is a potent transactivator and can be used in constructs to up-or downregulate genes or cDNAs, particularly genes or cDNAs under the control of a promoter containing an Ets element. Another of these domains, exon 7, is capable of acetylation and the level of acetylation can be used in assays for abnormal ESX regulation.
IPC 1-7
IPC 8 full level
C07K 14/47 (2006.01); C07K 14/82 (2006.01); C12Q 1/68 (2006.01); G01N 33/68 (2006.01); A61K 38/00 (2006.01)
CPC (source: EP)
B82Y 5/00 (2013.01); B82Y 10/00 (2013.01); C07K 14/4705 (2013.01); C07K 14/82 (2013.01); C12Q 1/6897 (2013.01); G01N 33/6872 (2013.01); A61K 38/00 (2013.01); C07K 2319/00 (2013.01); C12Q 1/6886 (2013.01)
Citation (search report)
See references of WO 9965929A1
Designated contracting state (EPC)
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
DOCDB simple family (publication)
WO 9965929 A1 19991223; AU 4563599 A 20000105; CA 2331266 A1 19991223; EP 1087985 A1 20010404
DOCDB simple family (application)
US 9913277 W 19990615; AU 4563599 A 19990615; CA 2331266 A 19990615; EP 99928601 A 19990615