EP 1088070 A2 20010404 - INTERFERENCE WITH VIRAL IRES-MEDIATED TRANSLATION BY A SMALL YEAST RNA REVEALS CRITICAL RNA-PROTEIN INTERACTIONS
Title (en)
INTERFERENCE WITH VIRAL IRES-MEDIATED TRANSLATION BY A SMALL YEAST RNA REVEALS CRITICAL RNA-PROTEIN INTERACTIONS
Title (de)
SELEKTIVE HEMMUNG VON INTERN INITIERTER RNA TRANSLATIONS
Title (fr)
MISE EN EVIDENCE DES INTERACTIONS CRITIQUES ENTRE PROTEINES D'ARN PAR INTERFERENCE AVEC LA TRADUCTION VIRALE A MEDIATION D'IRES PAR L'ARN D'UNE PETITE LEVURE
Publication
Application
Priority
- US 9911281 W 19990521
- US 8652798 P 19980522
Abstract (en)
[origin: WO9961613A2] Peptides and RNA oligonucleotides and methods of use for the inhibition of translation of an mRNA, which is initiated at an internal ribosome entry site of the mRNA and requires binding of a protein factor to that site, are disclosed. Peptides comprising the La autoantigen binding domain (LAP) are disclosed. LAP peptides alone or in combination with inhibitor RNA oligonucleotides (IRNA) may be used as antiviral agents to inhibit internal ribosome entry site (IRES) mediated viral replication.
IPC 1-7
IPC 8 full level
A61K 38/00 (2006.01); A61P 31/14 (2006.01); A61P 31/16 (2006.01); C07K 7/00 (2006.01); C07K 14/47 (2006.01); C12N 15/09 (2006.01); C12N 15/11 (2006.01); C12N 15/12 (2006.01)
CPC (source: EP)
A61P 31/14 (2017.12); A61P 31/16 (2017.12); C07K 14/4703 (2013.01); C12N 15/11 (2013.01); C12N 15/67 (2013.01); A61K 38/00 (2013.01); Y02A 50/30 (2017.12)
Citation (search report)
See references of WO 9961613A2
Designated contracting state (EPC)
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
DOCDB simple family (publication)
WO 9961613 A2 19991202; WO 9961613 A3 20000217; AU 4542499 A 19991213; AU 770432 B2 20040219; CA 2329155 A1 19991202; EP 1088070 A2 20010404; JP 2002516100 A 20020604
DOCDB simple family (application)
US 9911281 W 19990521; AU 4542499 A 19990521; CA 2329155 A 19990521; EP 99928330 A 19990521; JP 2000550997 A 19990521