EP 1088078 A2 20010404 - GENES FOR THE BIOSYNTHESIS OF EPOTHILONES
Title (en)
GENES FOR THE BIOSYNTHESIS OF EPOTHILONES
Title (de)
GENE FÜR BIOSYNTHESE VON EPOTHILONE
Title (fr)
GENES POUR LA BIOSYNTHESE D'EPOTHILONES
Publication
Application
Priority
- EP 9904171 W 19990616
- US 9950498 A 19980618
- US 10163198 P 19980924
- US 11890699 P 19990205
Abstract (en)
[origin: WO9966028A2] Nucleic acid molecules are isolated from Sorangium cellulosum that encode polypeptides necessary for the biosynthesis of epothilone. Disclosed are methods for the production of epothilone in recombinant hosts transformed with the genes of the invention. In this manner, epothilone can be produced in quantities large enough to enable their purification and use in pharmaceutical formulations such as those for the treatment of cancer.
IPC 1-7
IPC 8 full level
C07K 14/195 (2006.01); C12N 1/21 (2006.01); C12N 9/00 (2006.01); C12N 15/09 (2006.01); C12P 7/00 (2006.01); C12P 17/18 (2006.01); C12R 1/01 (2006.01); C12R 1/465 (2006.01)
CPC (source: EP KR)
A61P 35/04 (2018.01 - EP); C07K 14/195 (2013.01 - EP); C12N 15/52 (2013.01 - KR); C12P 17/181 (2013.01 - EP)
Designated contracting state (EPC)
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
DOCDB simple family (publication)
WO 9966028 A2 19991223; WO 9966028 A3 20000629; AU 4611699 A 20000105; AU 753567 B2 20021024; BR 9911349 A 20010313; CA 2329774 A1 19991223; CN 100374565 C 20080312; CN 1305530 A 20010725; EP 1088078 A2 20010404; HU P0102186 A2 20011028; HU P0102186 A3 20051028; ID 29128 A 20010802; IL 139735 A0 20020210; IL 139735 A 20090615; IL 190391 A0 20081103; JP 2002518004 A 20020625; JP 2006061166 A 20060309; JP 2008092958 A 20080424; KR 100511233 B1 20050831; KR 20010052962 A 20010625; NO 20006195 D0 20001206; NO 20006195 L 20010216; NO 20091055 L 20010216; NZ 508326 A 20031031; PL 200157 B1 20081231; PL 345579 A1 20011217; SK 19242000 A3 20010710; TR 200003759 T2 20010621
DOCDB simple family (application)
EP 9904171 W 19990616; AU 4611699 A 19990616; BR 9911349 A 19990616; CA 2329774 A 19990616; CN 99807421 A 19990616; EP 99929243 A 19990616; HU P0102186 A 19990616; ID 20002594 A 19990616; IL 13973500 A 20001116; IL 13973599 A 19990616; IL 19039108 A 20080324; JP 2000554837 A 19990616; JP 2005305998 A 20051020; JP 2007334606 A 20071226; KR 20007014348 A 20001216; NO 20006195 A 20001206; NO 20091055 A 20090309; NZ 50832698 A 19980612; PL 34557999 A 19990616; SK 19242000 A 19990616; TR 200003759 T 19990616