EP 1088079 A2 20010404 - NEK-RELATED AND BUB1-RELATED PROTEIN KINASES
Title (en)
NEK-RELATED AND BUB1-RELATED PROTEIN KINASES
Title (de)
NEK-VERWANDTE UND BUB1-VERWANDTE PROTEINKINASEN
Title (fr)
KINASES EN RAPPORT AVEC NEK ET AVEC BUB1
Publication
Application
Priority
- US 9913533 W 19990615
- US 8952098 P 19980616
- US 9826598 P 19980828
Abstract (en)
[origin: WO9966051A2] The present invention relates to BUB1 and NEK kinase polypeptides, nucleotide sequences encoding the kinase polypeptides, as well as various products and methods useful for the diagnosis and treatment of various kinase-related diseases and conditions. Through the use of a targeted PCR cloning strategy, the human BUB1 serine/threonine kinase was identified and its protein structure was predicted. Additionally, through the use of a bioinformatics strategy, three mammalian members of the NEK-subfamily of STK's have been identified and their protein structure predicted.
IPC 1-7
C12N 15/54; C12N 9/12; C12Q 1/68; C07K 16/40; C12Q 1/48; G01N 33/50; A61K 35/00; C12N 15/11
IPC 8 full level
A61K 38/45 (2006.01); A61K 45/00 (2006.01); A61K 48/00 (2006.01); A61P 25/28 (2006.01); A61P 35/00 (2006.01); A61P 35/02 (2006.01); A61P 37/00 (2006.01); C07K 16/40 (2006.01); C12N 1/15 (2006.01); C12N 1/19 (2006.01); C12N 1/21 (2006.01); C12N 5/10 (2006.01); C12N 9/12 (2006.01); C12N 15/09 (2006.01); C12N 15/54 (2006.01); C12Q 1/48 (2006.01); C12Q 1/68 (2006.01); G01N 33/15 (2006.01); G01N 33/50 (2006.01); G01N 33/68 (2006.01)
CPC (source: EP)
A61P 25/28 (2017.12); A61P 35/00 (2017.12); A61P 35/02 (2017.12); A61P 37/00 (2017.12); C12N 9/1205 (2013.01)
Citation (search report)
See references of WO 9966051A2
Designated contracting state (EPC)
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
DOCDB simple family (publication)
WO 9966051 A2 19991223; WO 9966051 A3 20000615; AU 4686299 A 20000105; CA 2331889 A1 19991223; EP 1088079 A2 20010404; JP 2002518016 A 20020625
DOCDB simple family (application)
US 9913533 W 19990615; AU 4686299 A 19990615; CA 2331889 A 19990615; EP 99930298 A 19990615; JP 2000554860 A 19990615