Global Patent Index - EP 1089732 A4

EP 1089732 A4 20010919 - COMPOSITIONS AND METHODS FOR TREATING ELEVATED BLOOD CHOLESTEROL

Title (en)

COMPOSITIONS AND METHODS FOR TREATING ELEVATED BLOOD CHOLESTEROL

Title (de)

ZUSAMMENSTELLUNGEN UND METHODEN ZUR BEHANDLUNG VON ERHÖHTEM BLUTCHOLESTEROLSPIEGEL

Title (fr)

COMPOSITIONS ET METHODES DE TRAITEMENT D'UNE CHOLESTEROLEMIE ELEVEE

Publication

EP 1089732 A4 20010919 (EN)

Application

EP 99930452 A 19990621

Priority

  • GB 9817174 A 19980806
  • US 9913888 W 19990621
  • US 9040498 P 19980624

Abstract (en)

[origin: WO9966930A1] The present invention relates to compositions and methods for treating elevated blood cholesterol in a mammal while counteracting the occurrence of potentially adverse side effects such as myopathy. The compositions useful herein comprise the combination of a pharmaceutically effective amount of a 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor (hereafter "HMG-CoA reductase inhibitor") and a caspase inhibitor to a mammal in need thereof.

IPC 1-7

A61K 31/405; A61K 38/06; A61K 38/07

IPC 8 full level

A61K 45/06 (2006.01); A61K 31/215 (2006.01); A61K 31/365 (2006.01); A61K 31/40 (2006.01); A61K 31/405 (2006.01); A61K 38/00 (2006.01); A61K 38/55 (2006.01); A61P 3/06 (2006.01); A61P 9/00 (2006.01); A61P 9/10 (2006.01); A61P 43/00 (2006.01)

CPC (source: EP)

A61K 38/005 (2013.01); A61K 38/55 (2013.01); A61P 3/06 (2017.12); A61P 9/00 (2017.12); A61P 9/10 (2017.12); A61P 43/00 (2017.12)

C-Set (source: EP)

  1. A61K 38/55 + A61K 31/44
  2. A61K 38/005 + A61K 2300/00
  3. A61K 38/55 + A61K 2300/00
  4. A61K 38/55 + A61K 31/405
  5. A61K 38/55 + A61K 31/40
  6. A61K 38/55 + A61K 31/365
  7. A61K 38/55 + A61K 31/22
  8. A61K 38/005 + A61K 31/44
  9. A61K 38/005 + A61K 31/405
  10. A61K 38/005 + A61K 31/40
  11. A61K 38/005 + A61K 31/365 + A61K 31/22

Citation (search report)

  • [Y] RUDEL T: "CASPASE INHIBITORS IN PREVENTION OF APOPTOSIS CASPASEINHIBITOREN ZUR PRAEVENTION VON APOPTOSE", HERZ,URBAN UND VOGEL, MUENCHEN,DE, vol. 24, no. 3, 1994, pages 236 - 241, XP001009833, ISSN: 0340-9937
  • [Y] WU J C ET AL: "IRREVERSIBLE CASPASE INHIBITORS: TOOLS FOR STUDYING APOPTOSIS", METHODS: A COMPANION TO METHODS IN ENZYMOLOGY,ACADEMIC PRESS INC., NEW YORK, NY,US, vol. 17, no. 4, 1999, pages 320 - 328, XP001000619, ISSN: 1046-2023
  • [Y] HUGHES DAVID E ET AL: "Involvement of the mevalonate pathway in osteoclast apoptosis and the mechanism of action of bisphosphonates.", BONE (NEW YORK), vol. 20, no. 4 SUPPL., 1997, 25th European Symposium on Calcified Tissues;Harrogate, England, UK; April 25-29, 1997, pages 110S, XP002172609, ISSN: 8756-3282
  • See references of WO 9966930A1

Designated contracting state (EPC)

AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU NL PT SE

DOCDB simple family (publication)

WO 9966930 A1 19991229; AU 4699099 A 20000110; CA 2336192 A1 19991229; EP 1089732 A1 20010411; EP 1089732 A4 20010919; JP 2002518449 A 20020625

DOCDB simple family (application)

US 9913888 W 19990621; AU 4699099 A 19990621; CA 2336192 A 19990621; EP 99930452 A 19990621; JP 2000555616 A 19990621