Global Patent Index - EP 1089962 A1

EP 1089962 A1 2001-04-11 - 2-FLUORO-2-ALKYL ALKANOAMIDES WITH ANTICONVULSANT ACTIVITY

Title (en)

2-FLUORO-2-ALKYL ALKANOAMIDES WITH ANTICONVULSANT ACTIVITY

Title (de)

2-FLUORO-2-ALKYL ALKANOLAMIDE MIT ANTIKONVULSIVER WIRKUNG

Title (fr)

2-FLUORO-2-ALKYL ALKANOAMIDES AVEC ACTIVITE ANTIEPILEPTIQUE

Publication

EP 1089962 A1 (EN)

Application

EP 99930479 A

Priority

  • US 9913941 W
  • US 9028498 P

Abstract (en)

[origin: WO9967199A1] Alpha-fluorinated alkanoamides of formula (I), and pharmaceutical compositions containing them, are provided. The compounds and compositions are useful for the treatment and prevention of seizures such as are associated with epilepsy. The compounds of the invention exhibit an improved therapeutic ratio, relative to valproic acid, with regard to sedation and teratogenic potential, and exhibit improved pharmacokinetics and pharmacodynamics.

IPC 1-7 (main, further and additional classification)

C07C 233/03; A61K 31/16

IPC 8 full level (invention and additional information)

A61P 25/08 (2006.01); A61K 31/16 (2006.01); C07C 233/05 (2006.01)

CPC (invention and additional information)

C07C 233/05 (2013.01)

Citation (search report)

See references of WO 9967199A1

Designated contracting state (EPC)

AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

EPO simple patent family

WO 9967199 A1 19991229; AU 4701399 A 20000110; CA 2335598 A1 19991229; CN 1306503 A 20010801; EP 1089962 A1 20010411; JP 2002518469 A 20020625

INPADOC legal status


2003-08-27 [18D] DEEMED TO BE WITHDRAWN

- Effective date: 20030218

2002-11-20 [17Q] FIRST EXAMINATION REPORT

- Effective date: 20021007

2001-04-11 [17P] REQUEST FOR EXAMINATION FILED

- Effective date: 20001215

2001-04-11 [AK] DESIGNATED CONTRACTING STATES:

- Kind Code of Ref Document: A1

- Designated State(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE