Global Patent Index - EP 1089990 A1

EP 1089990 A1 2001-04-11 - 1-(BENZOTHIAZOL-2-YL)-4-(1-PHENYLMETHYL)PIPERAZINES: DOPAMINE RECEPTOR SUBTYPE SPECIFIC LIGANDS

Title (en)

1-(BENZOTHIAZOL-2-YL)-4-(1-PHENYLMETHYL)PIPERAZINES: DOPAMINE RECEPTOR SUBTYPE SPECIFIC LIGANDS

Title (de)

1(BENZOTHIAZOL-2-YL)-4-(PHENYLMETHYL)PIPERAZINE: DOPAMINREZEPTOR SUBTYP SPEZIFISCHER LIGANDEN

Title (fr)

1-(BENZOTHIAZOL-2-YL)-4-(1-PHENYLMETHYL)PIPERAZINES EN TANT QUE LIGANDS SPECIFIQUES DU SOUS-TYPE DU RECEPTEUR DE LA DOPAMINE

Publication

EP 1089990 A1 (EN)

Application

EP 99931915 A

Priority

  • US 9914427 W
  • US 10760798 A

Abstract (en)

[origin: WO0000482A1] Disclosed are compounds of formula (A) or pharmaceutically acceptable addition salts thereof wherein: R1 and R2 are the same or different and represent hydrogen, halogen, C1-C6 alkyl, C1-C6 alkoxy, C1-C6 alkylthio, hydroxy, amino, mono- or di(C1-C6) alkylamino, cyano or trifluoromethyl; Ar represents aryl or heteroaryl, each of which is optionally substituted with R3, R4 and/or R6; R3, R4, and R6 independently represent hydrogen, halogen, hydroxy, C1-C6 alkyl, C1-C6 alkoxy, perfluoro (C1-C6) alkyl, perfluoro (C1-C6) alkoxy, or SO2NH2; or R3 and R4 together with the atoms to which they are attached represent a ring having 5-7 atoms; and R5 represents hydrogen or C1-C6 alkyl, which compounds are useful for the treatment and/or prevention of neuropsychological disorders including, but not limited to, schizophrenia, mania, dementia, depression, anxiety, compulsive behavior, substance abuse, Parkinson-like motor disorders and motion disorders related to the use of neuroleptic agents.

IPC 1-7 (main, further and additional classification)

C07D 277/82; C07D 277/68

IPC 8 full level (invention and additional information)

A61K 31/496 (2006.01); A61P 25/00 (2006.01); A61P 25/16 (2006.01); A61P 25/18 (2006.01); A61P 25/30 (2006.01); C07D 277/68 (2006.01); C07D 277/82 (2006.01)

CPC (invention and additional information)

C07D 277/68 (2013.01); C07D 277/82 (2013.01)

Citation (search report)

See references of WO 0000482A1

Designated contracting state (EPC)

AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

EPO simple patent family

WO 0000482 A1 20000106; AU 4832699 A 20000117; CA 2336150 A1 20000106; EP 1089990 A1 20010411; JP 2002519346 A 20020702

INPADOC legal status


2004-01-07 [18D] DEEMED TO BE WITHDRAWN

- Effective date: 20030701

2003-04-02 [17Q] FIRST EXAMINATION REPORT

- Effective date: 20030218

2001-04-11 [17P] REQUEST FOR EXAMINATION FILED

- Effective date: 20010122

2001-04-11 [AK] DESIGNATED CONTRACTING STATES:

- Kind Code of Ref Document: A1

- Designated State(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

2001-04-11 [AX] REQUEST FOR EXTENSION OF THE EUROPEAN PATENT TO

- Free text: AL PAYMENT 20010122;LT PAYMENT 20010122;LV PAYMENT 20010122;MK PAYMENT 20010122;RO PAYMENT 20010122;SI PAYMENT 20010122