EP 1090113 A1 20010411 - METHODS FOR TRANSFERRING THE CAPABILITY TO PRODUCE A NATURAL PRODUCT INTO A SUITABLE PRODUCTION HOST
Title (en)
METHODS FOR TRANSFERRING THE CAPABILITY TO PRODUCE A NATURAL PRODUCT INTO A SUITABLE PRODUCTION HOST
Title (de)
METHODE ZUR ÜBERFÜHRUNG DER FÄHIGKEIT NATURSTOFFE ZU SYNTHETISIEREN IN GEEIGNETE WIRTSORGANISMEN
Title (fr)
PROCEDES DE TRANSFERT DE LA CAPACITE DE PRODUCTION D'UN PRODUIT NATUREL DANS UN HOTE DE PRODUCTION APPROPRIE
Publication
Application
Priority
- EP 99929199 A 19990614
- EP 9904079 W 19990614
- EP 98111506 A 19980623
- EP 99107554 A 19990415
Abstract (en)
[origin: WO9967374A1] The present invention provides a system for producing and modifying natural products produced by a large group of bacteria for the purpose of drug discovery, development and production. The method of the invention transfers the ability to produce a secondary metabolite from an actinomycete that is the original producer of the natural product, to a different production host that has desirable characteristics. The system involves the construction of a segment of the chromosome of the original producer in an artificial chromosome that can be stably maintained in a suitable production host. The present invention relates to recombinant DNA vectors useful for shuttling the genetic information necessary to synthesize a given natural product between a donor organism and a production host. The methods of the invention are useful in improving the yield, the purification process and for structural modification of a natural product.
IPC 1-7
C12N 15/10; C12N 15/52; C12N 15/70; C12N 15/76; C12N 1/21; C12P 19/62; C12P 17/18
IPC 8 full level
C12N 1/21 (2006.01); C12N 15/09 (2006.01); C12N 15/10 (2006.01); C12N 15/52 (2006.01); C12N 15/70 (2006.01); C12N 15/76 (2006.01); C12P 17/18 (2006.01); C12P 19/62 (2006.01); C12R 1/465 (2006.01); C12R 1/645 (2006.01)
CPC (source: EP KR)
C12N 15/1034 (2013.01 - EP); C12N 15/52 (2013.01 - EP); C12N 15/70 (2013.01 - EP); C12N 15/76 (2013.01 - EP KR); C12P 17/188 (2013.01 - EP); C12P 17/189 (2013.01 - EP); C12P 19/62 (2013.01 - EP)
Citation (search report)
See references of WO 9967374A1
Designated contracting state (EPC)
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
DOCDB simple family (publication)
WO 9967374 A1 19991229; AU 4609699 A 20000110; AU 743003 B2 20020117; CA 2330543 A1 19991229; EP 1090113 A1 20010411; IL 140021 A0 20020210; JP 2002518045 A 20020625; KR 20010083061 A 20010831
DOCDB simple family (application)
EP 9904079 W 19990614; AU 4609699 A 19990614; CA 2330543 A 19990614; EP 99929199 A 19990614; IL 14002199 A 19990614; JP 2000556019 A 19990614; KR 20007014621 A 20001222