Global patent index - EP 1090113 A1

EP 1090113 A1 2001-04-11 - METHODS FOR TRANSFERRING THE CAPABILITY TO PRODUCE A NATURAL PRODUCT INTO A SUITABLE PRODUCTION HOST

Title (en)

METHODS FOR TRANSFERRING THE CAPABILITY TO PRODUCE A NATURAL PRODUCT INTO A SUITABLE PRODUCTION HOST

Title (de)

METHODE ZUR ÜBERFÜHRUNG DER FÄHIGKEIT NATURSTOFFE ZU SYNTHETISIEREN IN GEEIGNETE WIRTSORGANISMEN

Title (fr)

PROCEDES DE TRANSFERT DE LA CAPACITE DE PRODUCTION D'UN PRODUIT NATUREL DANS UN HOTE DE PRODUCTION APPROPRIE

Publication

EP 1090113 A1 (EN)

Application

EP 99929199 A

Priority

  • EP 99929199 A
  • EP 9904079 W
  • EP 98111506 A
  • EP 99107554 A

Abstract (en)

[origin: WO9967374A1] The present invention provides a system for producing and modifying natural products produced by a large group of bacteria for the purpose of drug discovery, development and production. The method of the invention transfers the ability to produce a secondary metabolite from an actinomycete that is the original producer of the natural product, to a different production host that has desirable characteristics. The system involves the construction of a segment of the chromosome of the original producer in an artificial chromosome that can be stably maintained in a suitable production host. The present invention relates to recombinant DNA vectors useful for shuttling the genetic information necessary to synthesize a given natural product between a donor organism and a production host. The methods of the invention are useful in improving the yield, the purification process and for structural modification of a natural product.

IPC 1-7 (main, further and additional classification)

C12N 15/10; C12N 1/21; C12N 15/52; C12N 15/70; C12N 15/76; C12P 17/18; C12P 19/62

IPC 8 full level (invention and additional information)

C12N 15/09 (2006.01); C12N 1/21 (2006.01); C12N 15/10 (2006.01); C12N 15/52 (2006.01); C12N 15/70 (2006.01); C12N 15/76 (2006.01); C12P 17/18 (2006.01); C12P 19/62 (2006.01); C12R 1/465 (2006.01); C12R 1/645 (2006.01)

CPC (invention and additional information)

C12P 17/189 (2013.01); C12N 15/1034 (2013.01); C12N 15/52 (2013.01); C12N 15/70 (2013.01); C12N 15/76 (2013.01); C12P 17/188 (2013.01); C12P 19/62 (2013.01)

Citation (search report)

See references of WO 9967374A1

Designated contracting state (EPC)

AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

EPO simple patent family

WO 9967374 A1 19991229; AU 4609699 A 20000110; AU 743003 B2 20020117; CA 2330543 A1 19991229; EP 1090113 A1 20010411; IL 140021 D0 20020210; JP 2002518045 A 20020625

INPADOC legal status

2005-02-02 [18D] DEEMED TO BE WITHDRAWN

- Ref Legal Event Code: 18D

- Effective date: 20040730

2004-05-06 [17Q] FIRST EXAMINATION REPORT

- Ref Legal Event Code: 17Q

- Effective date: 20040319

2003-07-30 [RAP1] TRANSFER OF RIGHTS OF AN EP PUBLISHED APPLICATION

- Owner name: VICURON PHARMACEUTICALS, INC.

- Ref Legal Event Code: RAP1

2001-04-11 [17P] REQUEST FOR EXAMINATION FILED

- Ref Legal Event Code: 17P

- Effective date: 20001129

2001-04-11 [AK] DESIGNATED CONTRACTING STATES:

- Ref Legal Event Code: AK

- Designated State(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE