EP 1091726 A2 20010418 - ANALOGS OF 2-PHTHALIMIDINOGLUTARIC ACID AND THEIR USE AS INHIBITORS OF ANGIOGENESIS
Title (en)
ANALOGS OF 2-PHTHALIMIDINOGLUTARIC ACID AND THEIR USE AS INHIBITORS OF ANGIOGENESIS
Title (de)
ANALOGE DER 2-PHTHALIMIDINOGLUTARSÄURE UND IHRE VERWENDUNG ALS INHIBITOREN DER ANGIOGENESE
Title (fr)
ANALOGUES DE L'ACIDE 2-PHTHALIMIDINOGLUTARIQUE
Publication
Application
Priority
- US 9910287 W 19990511
- US 8503798 P 19980511
- US 9738498 P 19980821
- US 10803798 P 19981112
Abstract (en)
[origin: WO9958096A2] The invention provides new and useful analogs of 2-phthalimidinoglutaric acid. These analogs include DL-2- methyl-2- phthalimidinoglutaric acid and hydroxylated analogs of 2-phthalimidinoglutaric. The invention also provides processes for making these analogs. The invention also provides the two individual enantiomers of DL-2- methyl-2- phthalimidinoglutaric acid, (R)-(+)-2- methyl-2- phthalimidinoglutaric acid and (S)-(-)-2-methyl-2-phthalimidinoglutaric acid, and processes for separating these individual enantiomers from the racemate. Further, the invention provides methods for inhibiting angiogenesis and treating angiogenesis-associated diseases, including cancer and macular degeneration, by administering one or more of these compounds.
IPC 1-7
IPC 8 full level
A61K 31/403 (2006.01); A61K 31/4035 (2006.01); A61P 9/00 (2006.01); A61P 17/06 (2006.01); A61P 19/02 (2006.01); A61P 25/00 (2006.01); A61P 27/02 (2006.01); A61P 27/06 (2006.01); A61P 29/00 (2006.01); A61P 31/00 (2006.01); A61P 31/22 (2006.01); A61P 35/00 (2006.01); A61P 35/02 (2006.01); A61P 37/02 (2006.01); A61P 43/00 (2006.01); C07D 209/46 (2006.01)
CPC (source: EP)
A61P 9/00 (2017.12); A61P 17/06 (2017.12); A61P 19/02 (2017.12); A61P 25/00 (2017.12); A61P 27/02 (2017.12); A61P 27/06 (2017.12); A61P 29/00 (2017.12); A61P 31/00 (2017.12); A61P 31/22 (2017.12); A61P 35/00 (2017.12); A61P 35/02 (2017.12); A61P 37/02 (2017.12); A61P 43/00 (2017.12); C07D 209/46 (2013.01)
Citation (search report)
See references of WO 9958096A2
Designated contracting state (EPC)
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
DOCDB simple family (publication)
WO 9958096 A2 19991118; WO 9958096 A3 20000518; WO 9958096 A9 20000713; AU 4183799 A 19991129; AU 749356 B2 20020627; CA 2331461 A1 19991118; CA 2331461 C 20081007; EP 1091726 A2 20010418; JP 2002514578 A 20020521; KR 100699968 B1 20070328; KR 20010052332 A 20010625
DOCDB simple family (application)
US 9910287 W 19990511; AU 4183799 A 19990511; CA 2331461 A 19990511; EP 99925585 A 19990511; JP 2000547948 A 19990511; KR 20007012550 A 20001109