Title (en)

CARBOXYLIC AND HYDROXAMIC ACID COMPOUNDS INHIBITING METALLOPROTEASES, METHOD FOR PREPARING SAME AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM

Title (de)

HYDROXAMSAÜRE- UND CARBONSAÜREVERBINDUNGEN ALS METALLPROTEASEINHIBITOREN, VERFAHREN ZU IHRER HERSTELLUNG UND DIE ENTHALTENDE PHARMAZEUTISCHE ZUSAMMENSETZUNGEN

Title (fr)

COMPOSES ACIDES CARBOXYLIQUES ET HYDROXAMIQUES INH IBITEURS DE METALLOPROTEASES, PROCEDE POUR LEUR PREPARATION ET LES COMPOSITIONS PHARMACEUTIQUES LES CONTENANT

Publication

EP 1091937 A1 20010418 (FR)

Application

EP 99926559 A 19990629

Priority

• FR 9901556 W 19990629
• FR 9808301 A 19980630

Abstract (en)

[origin: FR2780402A1] (Hetero)aryl-substituted amino-carboxylic or -hydroxamic acid derivatives (I) are new. Carboxylic or hydroxamic acid derivatives of formula (I) and their enantiomers, diastereomers, acid addition salts and base addition salts are new. n = 0 or 1; R1-R4 = H or alkyl; or R1 + R3 = group completing a 5-8C cycloalkyl ring, in which case R2 = R4 = H; R5 = H, alkyl, 3-8C cycloalkyl or cycloalkyl-(3-8C)-alkyl or -CO-R6, or aryl, aralkyl, heteroaryl, heteroaralkyl, heterocycloalkyl or heterocycloalkylalkyl (all optionally substituted); R6 = R7, OR7 or NR7R8; or R5 + R6 together with the nitrogen atom and Z' = group completing a 5-16 membered, saturated, partially unsaturated or unsaturated, mono-, bi- or tricyclic ring system, containing 1-7 heteroatoms selected from N, O, S, SO and SO2 and optionally substituted by 1-7 of halo, alkyl, NH2, OH, alkoxy, NO2, SH, alkylthio, CN, =O, =NH, =S, COOH, alkoxycarbonyl, CONH2 and mono- or dialkylcarbamoyl; R7 = aryl, aralkyl heteroaryl or heteroaralkyl (all optionally substituted); R8 = alkyl; or aryl, aralkyl, heteroaryl, heteroaralkyl, heterocycloalkyl or heterocycloalkylalkyl (all optionally substituted); R10 = H; or OH, in which case R1-R4 = H or alkyl; Z' = CO or SO2; Y = OH, alkoxy, alkenyloxy, benzyloxy or NHOR; R = H, alkyl, alkenyl or benzyl; X = (i) S, SO or SO2, in which case R3 and R4 are other than alkyl; (ii) COO, in which case R1 + R3 complete cycloalkyl; or (iii) O; W = W1-(A)p or W1-B-W2-(A)p; W1, W2 = aryl or heteroaryl; A = ring substituent selected from halo, alkyl, alkoxy, OH, SH, CN, NH2, NO2, cyanoalkyl and thioalkyl; B = direct bond; or alkylene, alkenylene or alkynylene (all optionally having one C replaced by O); p = 0-5; T1, T2 = direct bond, alkylene, alkenylene or alkynylene; provided that if T2 = bond and n = 0 in the case that R1-R4 = H, then R5 + R6 = group completing a bicyclic heterocycle (as defined above) other than 1,3-dioxo-2,3-dihydro-1H-2-isoindolyl, 2,5-pyrrolidinedione or optionally substituted 2,5-dioxo-1-imidazolinyl. An Independent claims is included for the preparation method of (I).

IPC 1-7

C07D 209/48; C07D 471/04; C07D 209/46; C07D 275/06; C07D 237/32; C07D 253/08; C07D 265/26; C07D 239/96; C07D 263/44; C07D 233/74; C07D 277/34; C07D 253/04; C07D 209/66; C07D 221/14; A61K 31/40

IPC 8 full level

A61K 31/18 (2006.01); A61K 31/197 (2006.01); A61K 31/403 (2006.01); A61K 31/4035 (2006.01); A61K 31/425 (2006.01); A61K 31/426 (2006.01); A61K 31/428 (2006.01); A61K 31/517 (2006.01); A61K 31/53 (2006.01); A61K 31/535 (2006.01); A61K 31/536 (2006.01); A61K 31/537 (2006.01); A61P 19/02 (2006.01); A61P 29/00 (2006.01); A61P 35/00 (2006.01); A61P 35/04 (2006.01); C07D 253/04 (2006.01); A61P 43/00 (2006.01); C07C 233/82 (2006.01); C07C 233/83 (2006.01); C07C 259/10 (2006.01); C07C 311/29 (2006.01); C07D 209/48 (2006.01); C07D 209/66 (2006.01); C07D 231/22 (2006.01); C07D 233/72 (2006.01); C07D 233/74 (2006.01); C07D 237/32 (2006.01); C07D 239/96 (2006.01); C07D 253/08 (2006.01); C07D 265/06 (2006.01); C07D 265/16 (2006.01); C07D 275/04 (2006.01); C07D 275/06 (2006.01); C07D 277/20 (2006.01); C07D 277/34 (2006.01); C07D 401/12 (2006.01); C07D 403/12 (2006.01); C07D 409/12 (2006.01); C07D 471/04 (2006.01)

CPC (source: EP US)

A61P 19/02 (2018.01 - EP); A61P 29/00 (2018.01 - EP); A61P 35/00 (2018.01 - EP); A61P 35/04 (2018.01 - EP); A61P 43/00 (2018.01 - EP); C07C 233/82 (2013.01 - EP US); C07C 259/10 (2013.01 - EP US); C07C 311/29 (2013.01 - EP US); C07D 209/48 (2013.01 - EP US); C07D 231/22 (2013.01 - EP US); C07D 237/32 (2013.01 - EP US); C07D 239/96 (2013.01 - EP US); C07D 253/08 (2013.01 - EP US); C07D 275/06 (2013.01 - EP US); C07D 403/12 (2013.01 - EP US); C07D 409/12 (2013.01 - EP US); C07D 471/04 (2013.01 - EP US)

Designated contracting state (EPC)

AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

DOCDB simple family (publication)

US 6605604 B1 20030812; AU 4376299 A 20000117; AU 760456 B2 20030515; BR 9912499 A 20010502; CA 2335921 A1 20000106; CN 1307564 A 20010808; EP 1091937 A1 20010418; FR 2780402 A1 19991231; FR 2780402 B1 20010427; HU P0103221 A2 20020128; HU P0103221 A3 20031128; JP 2002519342 A 20020702; NO 20006611 D0 20001222; NO 20006611 L 20010202; PL 345101 A1 20011203; WO 0000473 A1 20000106; ZA 200007491 B 20010612

DOCDB simple family (application)

US 72085000 A 20001226; AU 4376299 A 19990629; BR 9912499 A 19990629; CA 2335921 A 19990629; CN 99808104 A 19990629; EP 99926559 A 19990629; FR 9808301 A 19980630; FR 9901556 W 19990629; HU P0103221 A 19990629; JP 2000557234 A 19990629; NO 20006611 A 20001222; PL 34510199 A 19990629; ZA 200007491 A 20001214