Global Patent Index - EP 1091949 A2

EP 1091949 A2 2001-04-18 - 6-(4-ARYLALKYLPIPERAZIN-1-YL)BENZODIOXANE AND 6-(4-ARYLALKYLPIPERAZIN-1-YL)CHROMANE DERIVATIVES: DOPAMINE RECEPTOR SUBTYPE SPECIFIC LIGANDS

Title (en)

6-(4-ARYLALKYLPIPERAZIN-1-YL)BENZODIOXANE AND 6-(4-ARYLALKYLPIPERAZIN-1-YL)CHROMANE DERIVATIVES: DOPAMINE RECEPTOR SUBTYPE SPECIFIC LIGANDS

Title (de)

6-(ARYLALKYLPIPERAZIN-1-YL)BENZODIOXANDERIVATE UND 6-(4-ARYLALKYLPIPERAZIN-1-YL)CHROMANDERIVATE :DOPAMIN REZEPTOR SUBTYP SPEZIFISCHE LIGANDEN

Title (fr)

DERIVES DE 6-(4-ARYLALKYLPIPERAZINE-1-YL)BENZODIOXANE ET DE 6-(4-ARYLALKYLPIPERAZINE-1-YL)CHROMANE EN TANT QUE LIGANDS SPECIFIQUE DU SOUS-TYPE DU RECEPTEUR DE LA DOPAMINE

Publication

EP 1091949 A2 (EN)

Application

EP 99930727 A

Priority

  • US 9914426 W
  • US 10924298 A

Abstract (en)

[origin: WO0000489A2] Disclosed are compounds of formula (I) or the pharmaceutically acceptable acid addition salts thereof, wherein: R1, R2, R3, R4 and R5 are the same or different and represent hydrogen, halogen, C1-C6 alkyl, C1-C6 alkoxy, C1-C4 alkylthio, hydroxy, amino, mono- or di(C1-C6)alkylamino, cyano, nitro, trifluoromethyl or trifluoromethoxy; and X is oxygen, a bond, C1-C2 alkylene or methyleneoxy, which compounds are useful for the treatment and/or prevention of neuropsychological disorders including, but not limited to, schizophrenia, mania, dementia, depression, anxiety, compulsive behavior, substance abuse, Parkinson-like motor disorders and motion disorders related to the use of neuroleptic agents.

IPC 1-7 (main, further and additional classification)

C07D 311/04; C07D 307/79; C07D 313/08; C07D 319/18; C07D 321/10; C07D 405/04

IPC 8 full level (invention and additional information)

A61K 31/496 (2006.01); A61P 25/00 (2006.01); A61P 25/16 (2006.01); A61P 25/18 (2006.01); A61P 25/22 (2006.01); A61P 25/24 (2006.01); A61P 25/28 (2006.01); A61P 25/30 (2006.01); A61P 43/00 (2006.01); C07D 307/79 (2006.01); C07D 311/58 (2006.01); C07D 313/08 (2006.01); C07D 319/18 (2006.01); C07D 321/10 (2006.01); C07D 405/04 (2006.01)

CPC (invention and additional information)

C07D 319/18 (2013.01); C07D 311/58 (2013.01); C07D 313/08 (2013.01); C07D 321/10 (2013.01)

Citation (search report)

See references of WO 0000489A3

Designated contracting state (EPC)

AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

EPO simple patent family

WO 0000489 A2 20000106; WO 0000489 A3 20000210; AU 4720499 A 20000117; CA 2336089 A1 20000106; EP 1091949 A2 20010418; JP 2002519350 A 20020702

INPADOC legal status


2002-09-25 [18D] DEEMED TO BE WITHDRAWN

- Effective date: 20020326

2001-10-31 [17Q] FIRST EXAMINATION REPORT

- Effective date: 20010913

2001-04-18 [17P] REQUEST FOR EXAMINATION FILED

- Effective date: 20010122

2001-04-18 [AK] DESIGNATED CONTRACTING STATES:

- Kind Code of Ref Document: A2

- Designated State(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

2001-04-18 [AX] REQUEST FOR EXTENSION OF THE EUROPEAN PATENT TO

- Free text: AL PAYMENT 20010122;LT PAYMENT 20010122;LV PAYMENT 20010122;MK PAYMENT 20010122;RO PAYMENT 20010122;SI PAYMENT 20010122