Global patent index - EP 1093367 A1

EP 1093367 A1 2001-04-25 - PROTEASE INHIBITORS

Title (en)

PROTEASE INHIBITORS

Title (de)

PROTEASEINHIBITOREN

Title (fr)

INHIBITEURS DE PROTEASES

Publication

EP 1093367 A1 (EN)

Application

EP 99930779 A

Priority

  • US 9914561 W
  • US 9049398 P

Abstract (en)

[origin: WO9966925A1] The present invention provides diacyl hydrazine compounds, and pharmaceutically acceptable salts, hydrates and solvates thereof, which inhibit proteases, including cathepsin K, pharmaceutical compositions of such compounds, novel intermediates of such compounds, and methods for treating diseases of excessive bone loss or cartilage or matrix degradation, including osteoporosis; gingival disease including gingivitis and periodontitis; arthritis, more specifically, osteoarthritis and rheumatoid arthritis; Paget's disease; hypercalcemia of malignancy; and metabolic bone disease, comprising inhibiting said bone loss or excessive cartilage or matrix degradation by administering to a patient in need thereof a compound of the present invention.

IPC 1-7 (main, further and additional classification)

A61K 31/34; A61K 31/36; A61K 31/38; A61K 31/39; A61K 31/41; A61K 31/415; A61K 31/425; A61K 31/445; A61K 31/505; A61K 31/535; C07D 215/14; C07D 231/12; C07D 263/32; C07D 277/10; C07D 277/66; C07D 285/06; C07D 307/80; C07D 317/50; C07D 319/20; C07D 333/78; C07D 401/12

IPC 8 full level (invention and additional information)

C07D 239/42 (2006.01); A61K 31/426 (2006.01); A61K 31/427 (2006.01); A61K 31/428 (2006.01); A61K 31/4365 (2006.01); A61K 31/4402 (2006.01); A61K 31/4418 (2006.01); A61K 31/4439 (2006.01); A61K 31/4709 (2006.01); A61K 31/506 (2006.01); A61K 31/5377 (2006.01); A61P 1/02 (2006.01); A61P 3/14 (2006.01); A61P 19/02 (2006.01); A61P 19/08 (2006.01); A61P 19/10 (2006.01); A61P 29/00 (2006.01); A61P 43/00 (2006.01); C07D 213/30 (2006.01); C07D 213/55 (2006.01); C07D 213/80 (2006.01); C07D 213/82 (2006.01); C07D 231/12 (2006.01); C07D 277/20 (2006.01); C07D 277/56 (2006.01); C07D 277/64 (2006.01); C07D 307/68 (2006.01); C07D 417/12 (2006.01); C07D 417/14 (2006.01); C07D 495/04 (2006.01)

CPC (invention and additional information)

C07D 417/12 (2013.01)

Designated contracting state (EPC)

BE CH DE ES FR GB IT LI NL

EPO simple patent family

WO 9966925 A1 19991229; AR 018915 A1 20011212; AU 4723799 A 20000110; CA 2335876 A1 19991229; EP 1093367 A1 20010425; EP 1093367 A4 20030305; JP 2002518444 A 20020625

INPADOC legal status

2003-11-19 [18D] DEEMED TO BE WITHDRAWN

- Ref Legal Event Code: 18D

- Effective date: 20030410

2003-03-05 [A4] SUPPLEMENTARY SEARCH REPORT

- Ref Legal Event Code: A4

- Effective date: 20030122

2001-04-25 [17P] REQUEST FOR EXAMINATION FILED

- Ref Legal Event Code: 17P

- Effective date: 20010123

2001-04-25 [AK] DESIGNATED CONTRACTING STATES:

- Ref Legal Event Code: AK

- Designated State(s): BE CH DE ES FR GB IT LI NL