EP 1093367 A1 20010425 - PROTEASE INHIBITORS
Title (en)
PROTEASE INHIBITORS
Title (de)
PROTEASEINHIBITOREN
Title (fr)
INHIBITEURS DE PROTEASES
Publication
Application
Priority
- US 9914561 W 19990624
- US 9049398 P 19980624
Abstract (en)
[origin: WO9966925A1] The present invention provides diacyl hydrazine compounds, and pharmaceutically acceptable salts, hydrates and solvates thereof, which inhibit proteases, including cathepsin K, pharmaceutical compositions of such compounds, novel intermediates of such compounds, and methods for treating diseases of excessive bone loss or cartilage or matrix degradation, including osteoporosis; gingival disease including gingivitis and periodontitis; arthritis, more specifically, osteoarthritis and rheumatoid arthritis; Paget's disease; hypercalcemia of malignancy; and metabolic bone disease, comprising inhibiting said bone loss or excessive cartilage or matrix degradation by administering to a patient in need thereof a compound of the present invention.
IPC 1-7
A61K 31/34; A61K 31/36; A61K 31/38; A61K 31/39; A61K 31/41; A61K 31/415; A61K 31/425; A61K 31/445; A61K 31/505; A61K 31/535; C07D 215/14; C07D 231/12; C07D 263/32; C07D 277/10; C07D 277/66; C07D 285/06; C07D 307/80; C07D 317/50; C07D 319/20; C07D 333/78; C07D 401/12
IPC 8 full level
A61K 31/426 (2006.01); A61K 31/427 (2006.01); A61K 31/428 (2006.01); A61K 31/4365 (2006.01); A61K 31/4402 (2006.01); A61K 31/4418 (2006.01); A61K 31/4439 (2006.01); A61K 31/4709 (2006.01); A61K 31/506 (2006.01); A61K 31/5377 (2006.01); A61P 1/02 (2006.01); A61P 3/14 (2006.01); A61P 19/02 (2006.01); A61P 19/08 (2006.01); A61P 19/10 (2006.01); A61P 29/00 (2006.01); A61P 43/00 (2006.01); C07D 213/30 (2006.01); C07D 213/55 (2006.01); C07D 213/80 (2006.01); C07D 213/82 (2006.01); C07D 231/12 (2006.01); C07D 239/42 (2006.01); C07D 277/20 (2006.01); C07D 277/56 (2006.01); C07D 277/64 (2006.01); C07D 307/68 (2006.01); C07D 417/12 (2006.01); C07D 417/14 (2006.01); C07D 495/04 (2006.01)
CPC (source: EP)
A61P 1/02 (2017.12); A61P 3/14 (2017.12); A61P 19/02 (2017.12); A61P 19/08 (2017.12); A61P 19/10 (2017.12); A61P 29/00 (2017.12); A61P 43/00 (2017.12); C07D 417/12 (2013.01)
Designated contracting state (EPC)
BE CH DE ES FR GB IT LI NL
DOCDB simple family (publication)
WO 9966925 A1 19991229; AR 018915 A1 20011212; AU 4723799 A 20000110; CA 2335876 A1 19991229; EP 1093367 A1 20010425; EP 1093367 A4 20030305; JP 2002518444 A 20020625
DOCDB simple family (application)
US 9914561 W 19990624; AR P990102984 A 19990622; AU 4723799 A 19990624; CA 2335876 A 19990624; EP 99930779 A 19990624; JP 2000555611 A 19990624