Global Patent Index - EP 1093580 A1

EP 1093580 A1 2001-04-25 - DIAGNOSIS OF PREDISPOSITION TO EPILEPSY AND MONITORING OF ANTIEPILEPTIC TREATMENT

Title (en)

DIAGNOSIS OF PREDISPOSITION TO EPILEPSY AND MONITORING OF ANTIEPILEPTIC TREATMENT

Title (de)

DIAGNOSE DER PRÄDISPOSITION ZUR EPILEPSIE UND ÜBERWACHUNG EINER ANTI-EPILEPTISCHEN BEHANDLUNG

Title (fr)

DIAGNOSTIC DE LA PREDISPOSITION A L'EPILEPSIE ET SURVEILLANCE DE TRAITEMENT ANTI-EPILEPTIQUE

Publication

EP 1093580 A1 (EN)

Application

EP 99919514 A

Priority

  • IL 9900252 W
  • IL 12444498 A

Abstract (en)

[origin: WO9958968A1] A method and a diagnostic system for the detection of a predisposition to epilepsy in a patient, for the diagnosis of clinical epilepsy itself and for monitoring of antiepileptic treatment. The method includes the steps of obtaining a sample in a patient, preferably a blood sample, determining a concentration in the sample of at least two kynurenine metabolites selected from the group consisting of TRP, L-KYN, KA, 3HOAA, AA and QUIN, those having functionally opposite properties, and correlating the concentration of these metabolites in the sample and the ratio between them with a range of values of these concentrations and ratios between them in normal individuals. In addition, the level of activity of enzymes in peripheral tissues such as blood cells can also be used to diagnose seizure disorders in the subject, as well as to detect a predisposition to such seizure disorders in the subject. For monitoring of antiepileptic treatment, the range of values of two of the metabolites and the ratio between them are compared with the ranges of values of concentrations and the ratio between them in epileptic patients well controlled or non-controlled by antiepileptic drugs.

IPC 1-7 (main, further and additional classification)

G01N 33/00; G01N 33/48

IPC 8 full level (invention and additional information)

A61K 45/00 (2006.01); A61P 25/08 (2006.01); G01N 33/15 (2006.01); G01N 33/487 (2006.01); G01N 33/53 (2006.01); G01N 33/68 (2006.01)

CPC (invention and additional information)

G01N 33/5308 (2013.01); G01N 33/6896 (2013.01); G01N 2800/2857 (2013.01); G01N 2800/52 (2013.01)

Designated contracting state (EPC)

AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

EPO simple patent family

WO 9958968 A1 19991118; AU 3727799 A 19991129; CA 2332021 A1 19991118; EP 1093580 A1 20010425; EP 1093580 A4 20010912; IL 124444 D0 19981206; JP 2002538412 A 20021112

INPADOC legal status


2003-03-05 [18D] DEEMED TO BE WITHDRAWN

- Effective date: 20020803

2002-07-17 [17Q] FIRST EXAMINATION REPORT

- Effective date: 20020123

2001-09-12 [A4] SUPPLEMENTARY SEARCH REPORT

- Effective date: 20010726

2001-09-12 [AK] DESIGNATED CONTRACTING STATES:

- Kind Code of Ref Document: A4

- Designated State(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

2001-09-12 [RIC1] CLASSIFICATION (CORRECTION)

- Free text: 7G 01N 33/00 A, 7G 01N 33/48 B, 7G 01N 33/68 B

2001-04-25 [17P] REQUEST FOR EXAMINATION FILED

- Effective date: 20001211

2001-04-25 [AK] DESIGNATED CONTRACTING STATES:

- Kind Code of Ref Document: A1

- Designated State(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE