EP 1094064 A1 20010425 - 5-arylindolederivatives and their use as serotonin(5-ht1)agonists

Title (en)

5-arylindolederivatives and their use as serotonin(5-ht1)agonists

Title (de)

5-Arylindol-Derivate und ihre Verwendung als Serotonin(5-ht1)-Agonisten

Title (fr)

Dérives de 5-arylindole et leur utilisation comme agonistes de la serotonine(5-ht1)

Publication

EP 1094064 A1 20010425 (EN)

Application

EP 00124422 A 19931019

Priority

EP 93923389 A 19931019
US 97075892 A 19921102

Abstract (en)

A compound of the formula <CHEM> wherein R1 is <CHEM> n is 0, 1, or 2; A, B, C, and D are each independently nitrogen or carbon; R2, R3, R4, and R5 are each independently hydrogen, C1 to C6 alkyl, aryl, C1 to C3 alkyl-aryl, halogen, cyano, nitro, -(CH2)mNR14R15, -(CH2)mOR9, -SR9, -SO2NR14R15, -(CH2)mNR14SO2R15, -(CH2)mNR14CO2R9, -(CH2)mNR14COR9, -(CH2)mNR14CONHR9, -CONR14R15, or -CO2R9; R2 and R3, R3 and R4, or R4 and R5 may be taken together to form a five- to seven-membered alkyl ring, a six-membered aryl ring, a five- to seven-membered heteroalkyl ring having 1 heteroatom of N, O, or S, or a five- to six-membered heteroaryl ring having 1 or 2 heteroatoms of N, O, or S; R6 is hydrogen, -OR10, or -NHCOR10; R7, R8, R14, and R15 are each independently hydrogen, C1 to C6 alkyl, -(CH2)xOR11, C1 to C3 alkyl-aryl, aryl; R7 and R8 or R14 and R15 may be taken together to form a three- to six-membered ring; R9 is hydrogen, C1 to C6 alkyl, C1 to C3 alkyl-aryl, or aryl; R10 is hydrogen, C1 to C6 alkyl, or C1 to C3 alkyl-aryl; R11 is hydrogen, C1 to C6 alkyl, or C1 to C3 alkyl-aryl; m is 0, 1, 2, or 3; x is 2 or 3; a broken line represents an optional double bond; and the above aryl groups and the aryl moieties of the above alkyl-aryl groups are independently phenyl or substituted phenyl, wherein said substituted phenyl may be substituted with one to three of C1 to C4 alkyl, halogen, hydroxy, cyano, carboxamido, nitro, or C1 to C4 alkoxy; or a pharmaceutically acceptable satt thereof.

IPC 1-7

C07D 471/04; C07D 403/04; C07D 403/14; C07D 401/14; A61K 31/415; A61K 31/44

IPC 8 full level

A61K 31/415 (2006.01); A61K 31/4184 (2006.01); A61K 31/4188 (2006.01); A61K 31/437 (2006.01); A61K 31/44 (2006.01); A61K 31/4427 (2006.01); A61K 31/454 (2006.01); A61P 3/04 (2006.01); A61P 9/12 (2006.01); A61P 25/00 (2006.01); A61P 25/04 (2006.01); A61P 25/06 (2006.01); A61P 25/24 (2006.01); A61P 43/00 (2006.01); C07D 401/14 (2006.01); C07D 403/04 (2006.01); C07D 403/14 (2006.01); C07D 471/04 (2006.01); C07D 487/04 (2006.01)

CPC (source: EP KR US)

A61P 3/04 (2018.01 - EP); A61P 9/12 (2018.01 - EP); A61P 25/00 (2018.01 - EP); A61P 25/04 (2018.01 - EP); A61P 25/06 (2018.01 - EP); A61P 25/24 (2018.01 - EP); A61P 43/00 (2018.01 - EP); C07D 401/14 (2013.01 - EP KR US); C07D 403/04 (2013.01 - EP US); C07D 403/14 (2013.01 - EP US); C07D 471/04 (2013.01 - EP KR US)

Citation (search report)

[DA] EP 0313397 A1 19890426 - WELLCOME FOUND [GB]
[A] EP 0465398 A2 19920108 - LUNDBECK & CO AS H [DK]
[A] WO 9206973 A1 19920430 - PFIZER [US]
[DA] WO 9118897 A1 19911212 - WELLCOME FOUND [GB]
[E] WO 9323396 A1 19931125 - MERCK SHARP & DOHME [GB], et al

Designated contracting state (EPC)

AT BE CH DE DK ES FR GB GR IE IT LI LU NL PT SE

DOCDB simple family (publication)

WO 9410171 A1 19940511; AT E202102 T1 20010615; AU 5329494 A 19940524; AU 685066 B2 19980115; BR 9307348 A 19990511; CA 2148380 A1 19940511; CA 2148380 C 20010814; CA 2340999 A1 19940511; CA 2340999 C 20050104; CN 1051313 C 20000412; CN 1094727 A 19941109; CZ 110895 A3 19951115; CZ 283001 B6 19971217; DE 69330351 D1 20010719; DE 69330351 T2 20010920; DK 0666858 T3 20010827; EG 20396 A 19990228; EP 0666858 A1 19950816; EP 0666858 B1 20010613; EP 1094064 A1 20010425; ES 2157224 T3 20010816; FI 111257 B 20030630; FI 20002505 A 20001115; FI 934825 A0 19931101; FI 934825 A 19940503; GR 3036579 T3 20011231; HU 222235 B1 20030528; HU T66011 A 19940829; IL 107386 A0 19940125; IL 107386 A 19990312; JP 2788551 B2 19980820; JP H07508759 A 19950928; KR 0163371 B1 19981201; KR 950704313 A 19951117; MY 109696 A 19970430; NO 309652 B1 20010305; NO 951633 D0 19950428; NO 951633 L 19950428; NZ 257059 A 19970727; PL 176091 B1 19990430; PL 308669 A1 19950821; PT 666858 E 20010928; RU 2134266 C1 19990810; RU 95109927 A 19970110; TW 251284 B 19950711; US 5886008 A 19990323; ZA 938137 B 19950502

DOCDB simple family (application)

US 9309790 W 19931019; AT 93923389 T 19931019; AU 5329494 A 19931019; BR 9307348 A 19931019; CA 2148380 A 19931019; CA 2340999 A 19931019; CN 93120716 A 19931101; CZ 110895 A 19931019; DE 69330351 T 19931019; DK 93923389 T 19931019; EG 69793 A 19931102; EP 00124422 A 19931019; EP 93923389 A 19931019; ES 93923389 T 19931019; FI 20002505 A 20001115; FI 934825 A 19931101; GR 20010401436 T 20010911; HU 9303118 A 19931102; IL 10738693 A 19931025; JP 51110193 A 19931019; KR 19950701729 A 19950502; MY PI19932280 A 19931101; NO 951633 A 19950428; NZ 25705993 A 19931019; PL 30866993 A 19931019; PT 93923389 T 19931019; RU 95109927 A 19931019; TW 82108604 A 19931016; US 42435795 A 19950427; ZA 938137 A 19931101