EP 1095046 A1 20010502 - IMPROVED PROCESS FOR THE PREPARATION OF SALTS AND ESTERS OF CLAVULANIC ACID
Title (en)
IMPROVED PROCESS FOR THE PREPARATION OF SALTS AND ESTERS OF CLAVULANIC ACID
Title (de)
VERBESSERTES VERFAHREN ZUR HERSTELLUNG VON CLAVULANSÄURE-SALZEN UND -ESTERN
Title (fr)
PROCEDE AMELIORE DE PREPARATION DE SELS ET D'ESTERS D'ACIDE CLAVULANIQUE
Publication
Application
Priority
- EP 99940010 A 19990713
- EP 9905026 W 19990713
- EP 98202390 A 19980716
Abstract (en)
[origin: WO0004028A1] A process for the production of an amine salt of clavulanic acid and the conversion thereof into a pharmaceutically acceptable salt or ester thereof has been provided. During the crystallisation phase of the amine salt of clavulanic acid either a clavulanic acid containing solution, optionally with a cosolvent, is added to the amine or both reactants are added together to a cristallisation vessel. Also the application of a temperature profile (decreasing in time), profile of speed of addition (increasing in time) and a profile of the ratio amine/clavulanic acid (increasing in time) for this cristallisation process has been provided for.
IPC 1-7
IPC 8 full level
C07D 503/00 (2006.01); C12P 17/18 (2006.01)
CPC (source: EP)
C07D 503/00 (2013.01); C12P 17/188 (2013.01)
Citation (search report)
See references of WO 0004028A1
Designated contracting state (EPC)
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
DOCDB simple family (publication)
WO 0004028 A1 20000127; AU 5411099 A 20000207; CA 2337072 A1 20000127; CN 1312814 A 20010912; EP 1095046 A1 20010502; TR 200100082 T2 20010621
DOCDB simple family (application)
EP 9905026 W 19990713; AU 5411099 A 19990713; CA 2337072 A 19990713; CN 99809491 A 19990713; EP 99940010 A 19990713; TR 200100082 T 19990713