Global Patent Index - EP 1095046 A1

EP 1095046 A1 2001-05-02 - IMPROVED PROCESS FOR THE PREPARATION OF SALTS AND ESTERS OF CLAVULANIC ACID

Title (en)

IMPROVED PROCESS FOR THE PREPARATION OF SALTS AND ESTERS OF CLAVULANIC ACID

Title (de)

VERBESSERTES VERFAHREN ZUR HERSTELLUNG VON CLAVULANSÄURE-SALZEN UND -ESTERN

Title (fr)

PROCEDE AMELIORE DE PREPARATION DE SELS ET D'ESTERS D'ACIDE CLAVULANIQUE

Publication

EP 1095046 A1 (EN)

Application

EP 99940010 A

Priority

  • EP 99940010 A
  • EP 9905026 W
  • EP 98202390 A

Abstract (en)

[origin: WO0004028A1] A process for the production of an amine salt of clavulanic acid and the conversion thereof into a pharmaceutically acceptable salt or ester thereof has been provided. During the crystallisation phase of the amine salt of clavulanic acid either a clavulanic acid containing solution, optionally with a cosolvent, is added to the amine or both reactants are added together to a cristallisation vessel. Also the application of a temperature profile (decreasing in time), profile of speed of addition (increasing in time) and a profile of the ratio amine/clavulanic acid (increasing in time) for this cristallisation process has been provided for.

IPC 1-7 (main, further and additional classification)

C07D 503/00; C12P 17/18

IPC 8 full level (invention and additional information)

C07D 503/00 (2006.01); C12P 17/18 (2006.01)

CPC (invention and additional information)

C12P 17/188 (2013.01); C07D 503/00 (2013.01)

Citation (search report)

See references of WO 0004028A1

Designated contracting state (EPC)

AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

EPO simple patent family

WO 0004028 A1 20000127; AU 5411099 A 20000207; CA 2337072 A1 20000127; CN 1312814 A 20010912; EP 1095046 A1 20010502; TR 200100082 T2 20010621

INPADOC legal status


2002-09-11 [18D] DEEMED TO BE WITHDRAWN

- Effective date: 20020312

2001-10-17 [17Q] FIRST EXAMINATION REPORT

- Effective date: 20010831

2001-05-02 [17P] REQUEST FOR EXAMINATION FILED

- Effective date: 20001222

2001-05-02 [AK] DESIGNATED CONTRACTING STATES:

- Kind Code of Ref Document: A1

- Designated State(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

2001-05-02 [AX] REQUEST FOR EXTENSION OF THE EUROPEAN PATENT TO

- Free text: AL PAYMENT 20001222;LT PAYMENT 20001222;LV PAYMENT 20001222;MK PAYMENT 20001222;RO PAYMENT 20001222;SI PAYMENT 20001222