EP 1095134 A1 20010502 - METHOD TO PREPARE C-TERMINAL MODIFIED PEPTIDES
Title (en)
METHOD TO PREPARE C-TERMINAL MODIFIED PEPTIDES
Title (de)
VERFAHREN ZUR HERSTELLUNG VON C-TERMINAL MODIFIZIERTEN PEPTIDEN
Title (fr)
PROCEDE DE PREPARATION DE PEPTIDES MODIFIES A TERMINAL C
Publication
Application
Priority
- GB 9901855 W 19990611
- GB 9812675 A 19980611
Abstract (en)
[origin: WO9964574A1] Non-peptide molecules of formula (I) may be used to mimic the structure of peptides and to bind with proteins which naturally bind peptide ligands. In said formula, C' is a substituted or unsubstituted carbon atom; X is a C1 to C4 chain in which each of the carbon atoms may be substituted or unsubstituted; and R<1> and R<2> are groups mimicking the side chains of a natural or unnatural amino acid. The molecules may either be used on their own, or may be incorporated into larger molecules such as polypeptides. In either case, they may be used as therapeutics to alter the activity of the protein. Additionally, they may be used to assay the proteins or to act as affinity ligands in their purification. Methods of manufacturing polypeptides incorporating the molecules of the invention are also described.
IPC 1-7
IPC 8 full level
A61K 47/48 (2006.01); A61P 43/00 (2006.01); C07K 1/04 (2006.01); C07K 1/107 (2006.01); C07K 19/00 (2006.01); C12N 9/90 (2006.01)
CPC (source: EP)
A61K 47/62 (2017.07); A61P 43/00 (2017.12); C07K 1/04 (2013.01); C07K 1/1077 (2013.01); C12N 9/90 (2013.01)
Citation (search report)
See references of WO 9964574A1
Designated contracting state (EPC)
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
DOCDB simple family (publication)
WO 9964574 A1 19991216; AU 4282599 A 19991230; EP 1095134 A1 20010502; GB 9812675 D0 19980812; JP 2002517233 A 20020618
DOCDB simple family (application)
GB 9901855 W 19990611; AU 4282599 A 19990611; EP 99955499 A 19990611; GB 9812675 A 19980611; JP 2000553564 A 19990611