EP 1095138 A2 20010502 - PRESENILIN 2 SPECIFIC RIBOZYME
Title (en)
PRESENILIN 2 SPECIFIC RIBOZYME
Title (de)
PRESENILIN 2-SPEZIFISCHES RIBOZYM
Title (fr)
RIBOZYME SPECIFIQUE DE PRESENILINE 2
Publication
Application
Priority
- EP 99934633 A 19990708
- EP 9904804 W 19990708
- EP 98112653 A 19980709
- US 12620099 P 19990325
Abstract (en)
[origin: WO0003004A2] The present invention relates to substances capable of inhibiting presenilin 2 expression in neurodegenerative diseases and in Alzheimer's disease. Ribozymes capable of cleaving presenilin 2-specific RNA are disclosed. Preferably, the invention concerns fusion ribozymes comprising a presenilin 2-specific ribozyme and an autocatalytical hammerhead ribozyme. Furthermore, recombinant DNA molecules coding for said ribozymes, a recombinant vector comprising the cDNA corresponding to said ribozymes and a host cell comprising said recombinant vector are disclosed. Additionally, the invention pertains to pharmaceutical compositions comprising said substance or ribozyme or recombinant vector and a pharmaceutically acceptable carrier. The invention also comprises the use of said substance or ribozyme or recombinant vector for the treatment of neurodegenerative diseases or for the treatment of Alzheimer's disease.
IPC 1-7
IPC 8 full level
A61K 31/7088 (2006.01); A61K 45/00 (2006.01); A61K 48/00 (2006.01); A61P 25/00 (2006.01); A61P 25/28 (2006.01); C12N 9/00 (2006.01); C12N 15/09 (2006.01); C12N 15/11 (2006.01); C12N 15/113 (2010.01); A61K 38/00 (2006.01)
CPC (source: EP)
A61P 25/00 (2017.12); A61P 25/28 (2017.12); C12N 15/113 (2013.01); A61K 38/00 (2013.01); C12N 2310/111 (2013.01); C12N 2310/121 (2013.01)
Citation (search report)
See references of WO 0003004A2
Designated contracting state (EPC)
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
DOCDB simple family (publication)
WO 0003004 A2 20000120; WO 0003004 A3 20000420; AR 020329 A1 20020508; AU 5033999 A 20000201; CA 2332497 A1 20000120; EP 1095138 A2 20010502; JP 2002520016 A 20020709
DOCDB simple family (application)
EP 9904804 W 19990708; AR P990103296 A 19990707; AU 5033999 A 19990708; CA 2332497 A 19990708; EP 99934633 A 19990708; JP 2000559226 A 19990708