Global Patent Index - EP 1095138 A2

EP 1095138 A2 2001-05-02 - PRESENILIN 2 SPECIFIC RIBOZYME

Title (en)

PRESENILIN 2 SPECIFIC RIBOZYME

Title (de)

PRESENILIN 2-SPEZIFISCHES RIBOZYM

Title (fr)

RIBOZYME SPECIFIQUE DE PRESENILINE 2

Publication

EP 1095138 A2 (EN)

Application

EP 99934633 A

Priority

  • EP 99934633 A
  • EP 9904804 W
  • EP 98112653 A
  • US 12620099 P

Abstract (en)

[origin: WO0003004A2] The present invention relates to substances capable of inhibiting presenilin 2 expression in neurodegenerative diseases and in Alzheimer's disease. Ribozymes capable of cleaving presenilin 2-specific RNA are disclosed. Preferably, the invention concerns fusion ribozymes comprising a presenilin 2-specific ribozyme and an autocatalytical hammerhead ribozyme. Furthermore, recombinant DNA molecules coding for said ribozymes, a recombinant vector comprising the cDNA corresponding to said ribozymes and a host cell comprising said recombinant vector are disclosed. Additionally, the invention pertains to pharmaceutical compositions comprising said substance or ribozyme or recombinant vector and a pharmaceutically acceptable carrier. The invention also comprises the use of said substance or ribozyme or recombinant vector for the treatment of neurodegenerative diseases or for the treatment of Alzheimer's disease.

IPC 1-7 (main, further and additional classification)

C12N 15/11

IPC 8 full level (invention and additional information)

C12N 15/09 (2006.01); A61K 31/7088 (2006.01); A61K 45/00 (2006.01); A61K 48/00 (2006.01); A61P 25/00 (2006.01); A61P 25/28 (2006.01); C12N 9/00 (2006.01); C12N 15/113 (2010.01); A61K 38/00 (2006.01)

CPC (invention and additional information)

C12N 15/113 (2013.01); A61K 38/00 (2013.01); C12N 2310/111 (2013.01); C12N 2310/121 (2013.01)

Citation (search report)

See references of WO 0003004A3

Designated contracting state (EPC)

AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

EPO simple patent family

WO 0003004 A2 20000120; WO 0003004 A3 20000420; AR 020329 A1 20020508; AU 5033999 A 20000201; CA 2332497 A1 20000120; EP 1095138 A2 20010502; JP 2002520016 A 20020709

INPADOC legal status


2004-08-25 [18D] DEEMED TO BE WITHDRAWN

- Effective date: 20040201

2003-11-19 [17Q] FIRST EXAMINATION REPORT

- Effective date: 20031008

2001-05-02 [17P] REQUEST FOR EXAMINATION FILED

- Effective date: 20010209

2001-05-02 [AK] DESIGNATED CONTRACTING STATES:

- Kind Code of Ref Document: A2

- Designated State(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

2001-05-02 [AX] REQUEST FOR EXTENSION OF THE EUROPEAN PATENT TO

- Free text: LT;LV;RO;SI