Global Patent Index - EP 1095279 A1

EP 1095279 A1 2001-05-02 - METHOD FOR IDENTIFYING A PRESENILINASE INHIBITOR

Title (en)

METHOD FOR IDENTIFYING A PRESENILINASE INHIBITOR

Title (de)

VERFAHREN ZUM NACHWEIS VON PRESENILINASE-INHIBITOREN

Title (fr)

METHODE D'IDENTIFICATION D'UN INHIBITEUR DE LA PRESENILINASE

Publication

EP 1095279 A1 (EN)

Application

EP 99934634 A

Priority

  • EP 99934634 A
  • EP 9904805 W
  • EP 98112688 A

Abstract (en)

[origin: WO0003248A1] The present invention pertains to methods for identifying a substance capable of reducing or eliminating the activity of the presenilinase wherein a cell or a cell line is cultivated expressing said presenilinase activity and a fusion-protein comprising the full-length presenilin 1 or presenilin 2 and a reporter is measured. The invention is furthermore concerned with substances identifiable with said methods, pharmaceutical compositions comprising said substances and the use of said substances in the manufacture of a medicament for the treatment of neurodegenerative diseases or Alzheimer's disease.

IPC 1-7 (main, further and additional classification)

G01N 33/68; A01K 67/027; C07K 14/47; G01N 33/573

IPC 8 full level (invention and additional information)

G01N 33/50 (2006.01); A01K 67/027 (2006.01); A61K 31/711 (2006.01); A61K 45/00 (2006.01); A61K 48/00 (2006.01); A61P 25/28 (2006.01); A61P 43/00 (2006.01); C07K 14/47 (2006.01); C12N 9/99 (2006.01); C12N 15/09 (2006.01); C12Q 1/02 (2006.01); G01N 33/15 (2006.01); G01N 33/573 (2006.01); G01N 33/68 (2006.01)

CPC (invention and additional information)

G01N 33/573 (2013.01); G01N 33/6896 (2013.01)

Citation (search report)

See references of WO 0003248A1

Designated contracting state (EPC)

AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

EPO simple patent family

WO 0003248 A1 20000120; AR 020107 A1 20020410; AU 5034099 A 20000201; CA 2332344 A1 20000120; EP 1095279 A1 20010502; JP 2002520031 A 20020709; UY 25604 A1 20000223

INPADOC legal status


2003-08-06 [18D] APPLICATION DEEMED TO BE WITHDRAWN

- Effective date: 20030201

2001-05-02 [17P] REQUEST FOR EXAMINATION FILED

- Effective date: 20010209

2001-05-02 [AK] DESIGNATED CONTRACTING STATES:

- Kind Code of Ref Document: A1

- Designated State(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

2001-05-02 [AX] REQUEST FOR EXTENSION OF THE EUROPEAN PATENT TO:

- Free text: LT;LV;RO;SI