EP 1095279 A1 20010502 - METHOD FOR IDENTIFYING A PRESENILINASE INHIBITOR
Title (en)
METHOD FOR IDENTIFYING A PRESENILINASE INHIBITOR
Title (de)
VERFAHREN ZUM NACHWEIS VON PRESENILINASE-INHIBITOREN
Title (fr)
METHODE D'IDENTIFICATION D'UN INHIBITEUR DE LA PRESENILINASE
Publication
Application
Priority
- EP 99934634 A 19990708
- EP 9904805 W 19990708
- EP 98112688 A 19980709
Abstract (en)
[origin: WO0003248A1] The present invention pertains to methods for identifying a substance capable of reducing or eliminating the activity of the presenilinase wherein a cell or a cell line is cultivated expressing said presenilinase activity and a fusion-protein comprising the full-length presenilin 1 or presenilin 2 and a reporter is measured. The invention is furthermore concerned with substances identifiable with said methods, pharmaceutical compositions comprising said substances and the use of said substances in the manufacture of a medicament for the treatment of neurodegenerative diseases or Alzheimer's disease.
IPC 1-7
IPC 8 full level
A01K 67/027 (2006.01); A61K 31/711 (2006.01); A61K 45/00 (2006.01); A61K 48/00 (2006.01); A61P 25/28 (2006.01); A61P 43/00 (2006.01); C07K 14/47 (2006.01); C12N 9/99 (2006.01); C12N 15/09 (2006.01); C12Q 1/02 (2006.01); G01N 33/15 (2006.01); G01N 33/50 (2006.01); G01N 33/573 (2006.01); G01N 33/68 (2006.01)
CPC (source: EP)
A61P 25/28 (2017.12); A61P 43/00 (2017.12); G01N 33/573 (2013.01); G01N 33/6896 (2013.01)
Citation (search report)
See references of WO 0003248A1
Designated contracting state (EPC)
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
DOCDB simple family (publication)
WO 0003248 A1 20000120; AR 020107 A1 20020410; AU 5034099 A 20000201; CA 2332344 A1 20000120; EP 1095279 A1 20010502; JP 2002520031 A 20020709; UY 25604 A1 20000223
DOCDB simple family (application)
EP 9904805 W 19990708; AR P990103295 A 19990707; AU 5034099 A 19990708; CA 2332344 A 19990708; EP 99934634 A 19990708; JP 2000559432 A 19990708; UY 25604 A 19990709