EP 1098659 A2 20010516 - LIBRARIES OF POLYHYDROXAMATES AND THEIR ANALOGS
Title (en)
LIBRARIES OF POLYHYDROXAMATES AND THEIR ANALOGS
Title (de)
POLYHYDROXAMATBANKEN UND IHRE ANALOGA
Title (fr)
BANQUES DE POLYHYDROXAMATES ET LEURS ANALOGUES
Publication
Application
Priority
- US 9916848 W 19990723
- US 9388398 P 19980723
Abstract (en)
[origin: WO0004868A2] A method of synthesizing desired polyhydroxamates and polyhydroxamate analogs is provided. The method comprises linking a first component of the desired polyhydroxamate or polyhydroxamate analog to a support matrix under conditions effective to form a first matrix-bound intermediate of said desired polyhydroxamate or analog, extending said first matrix-bound intermediate using reagents and reaction conditions effective to form one or more additional matrix-bound intermediates of said desired polyhydroxamate or analog, thereby forming a matrix-bound precursor of the desired polyhydroxamate or polyhydroxamate analog. Protective groups used during synthesis of the precursor are removed and the matrix-bound precursor is cleared from the support matrix, thereby synthesizing the desired polyhydroxamate or polyhydroxamate analog. Methods of making, screening and selecting libraries of candidate polyhydroxamates, the libraries and polyhydroxamates, polyhydroxamate analogs, their intermediates, and methods for using such compounds and their compositions are also disclosed.
IPC 1-7
A61K 38/00; G01N 33/53; G01N 33/567; G01N 33/566; G01N 33/543; C07K 5/00; C07C 233/00; C07C 239/00; C07C 241/00; C07C 255/00; C07C 259/04; C07C 259/06
IPC 8 full level
A61K 31/16 (2006.01); A61K 38/00 (2006.01); A61K 49/04 (2006.01); A61K 51/00 (2006.01); A61P 7/00 (2006.01); A61P 9/00 (2006.01); A61P 9/10 (2006.01); A61P 15/06 (2006.01); A61P 17/02 (2006.01); A61P 19/02 (2006.01); A61P 25/16 (2006.01); A61P 25/18 (2006.01); A61P 25/24 (2006.01); A61P 29/00 (2006.01); A61P 39/02 (2006.01); A61P 43/00 (2006.01); C07C 259/06 (2006.01); C07K 5/00 (2006.01); C08L 101/00 (2006.01); G01N 33/15 (2006.01); G01N 33/50 (2006.01); G01N 33/566 (2006.01); C07B 61/00 (2006.01)
CPC (source: EP)
A61P 7/00 (2017.12); A61P 9/00 (2017.12); A61P 9/10 (2017.12); A61P 15/06 (2017.12); A61P 17/02 (2017.12); A61P 19/02 (2017.12); A61P 25/16 (2017.12); A61P 25/18 (2017.12); A61P 25/24 (2017.12); A61P 29/00 (2017.12); A61P 39/02 (2017.12); A61P 43/00 (2017.12); C07C 259/06 (2013.01); C07B 2200/11 (2013.01); C40B 40/00 (2013.01); Y02P 20/55 (2015.11)
Designated contracting state (EPC)
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
DOCDB simple family (publication)
WO 0004868 A2 20000203; WO 0004868 A3 20000504; AU 5229599 A 20000214; CA 2337756 A1 20000203; EP 1098659 A2 20010516; EP 1098659 A4 20041124; JP 2002521319 A 20020716
DOCDB simple family (application)
US 9916848 W 19990723; AU 5229599 A 19990723; CA 2337756 A 19990723; EP 99937465 A 19990723; JP 2000560861 A 19990723