EP 1098888 A1 20010516 - PIPERAZINONE DERIVATIVES AND THEIR USES
Title (en)
PIPERAZINONE DERIVATIVES AND THEIR USES
Title (de)
PIPERAZINONEN DERIVATE UND DEREN VERWENDUNGEN
Title (fr)
DERIVES DE PIPERAZINONES ET LEURS APPLICATIONS
Publication
Application
Priority
- FR 9901747 W 19990716
- FR 9809168 A 19980717
Abstract (en)
[origin: FR2781220A1] 1-(4-amidino phenyl)-4-substituted piperazinone derivatives (I) are new. (I) are of formula (Q): R1 = H, 1-4C alkyl, or phenyl 1-4C alkyl; oxo group = may be in position 2 or 3 of the piperazine ring; R2 = H, OH, or a group protecting the amidino group; R3 = H, 1-5C alkyl, 3-12C mono- or bicyclic cycloalkyl, 2-4C alkenyl, or alkynyl, (these groups being optionally substituted by halogens or OH), 6-14C mono- bi- or tri-cyclic aryl, pyridyl, thienyl, furanyl, quinolyl, benzodioxanyl, benzodioxolyl, benzothienyl, benzofuranyl, pyrazinyl, phenyl 1-4C alkyl, naphthyl 1-4C alkyl, (both optionally substituted on the aryl ring) or piperonyl; R4 and R5 = H, 1-5C alkyl or, together with the N atom, form piperidinyl or morpholinyl, aryl and heteroaryl groups being optionally substituted by halogens, 1-4C alkyl, CF3, 1-4C alkylthio, alkoxy, alkylsulfonyl, NO2, -COOR, -CH2-COOR, or -O-CH2-COOR, and R = 1-4C alkyl.
IPC 1-7
IPC 8 full level
A61K 31/495 (2006.01); A61K 31/496 (2006.01); A61P 7/02 (2006.01); A61P 43/00 (2006.01); C07D 241/08 (2006.01); C07D 401/12 (2006.01); C07D 405/12 (2006.01)
CPC (source: EP US)
A61P 7/02 (2017.12 - EP); A61P 43/00 (2017.12 - EP); C07D 241/08 (2013.01 - EP US); C07D 401/12 (2013.01 - EP US); C07D 405/12 (2013.01 - EP US); Y02P 20/55 (2015.11 - EP US)
Citation (search report)
See references of WO 0004000A1
Designated contracting state (EPC)
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
DOCDB simple family (publication)
FR 2781220 A1 20000121; FR 2781220 B1 20001013; AU 4629199 A 20000207; AU 752632 B2 20020926; BR 9912839 A 20010605; CA 2337849 A1 20000127; CA 2337849 C 20090317; CN 1188402 C 20050209; CN 1309648 A 20010822; EA 003511 B1 20030626; EA 200100151 A1 20010625; EP 1098888 A1 20010516; JP 2002520401 A 20020709; NZ 509166 A 20040130; US 6344456 B1 20020205; WO 0004000 A1 20000127
DOCDB simple family (application)
FR 9809168 A 19980717; AU 4629199 A 19990716; BR 9912839 A 19990716; CA 2337849 A 19990716; CN 99808703 A 19990716; EA 200100151 A 19990716; EP 99929496 A 19990716; FR 9901747 W 19990716; JP 2000560107 A 19990716; NZ 50916699 A 19990716; US 74341101 A 20010110