Global Patent Index - EP 1098888 A1

EP 1098888 A1 2001-05-16 - PIPERAZINONE DERIVATIVES AND THEIR USES

Title (en)

PIPERAZINONE DERIVATIVES AND THEIR USES

Title (de)

PIPERAZINONEN DERIVATE UND DEREN VERWENDUNGEN

Title (fr)

DERIVES DE PIPERAZINONES ET LEURS APPLICATIONS

Publication

EP 1098888 A1 (FR)

Application

EP 99929496 A

Priority

  • FR 9901747 W
  • FR 9809168 A

Abstract (en)

[origin: FR2781220A1] 1-(4-amidino phenyl)-4-substituted piperazinone derivatives (I) are new. (I) are of formula (Q): R1 = H, 1-4C alkyl, or phenyl 1-4C alkyl; oxo group = may be in position 2 or 3 of the piperazine ring; R2 = H, OH, or a group protecting the amidino group; R3 = H, 1-5C alkyl, 3-12C mono- or bicyclic cycloalkyl, 2-4C alkenyl, or alkynyl, (these groups being optionally substituted by halogens or OH), 6-14C mono- bi- or tri-cyclic aryl, pyridyl, thienyl, furanyl, quinolyl, benzodioxanyl, benzodioxolyl, benzothienyl, benzofuranyl, pyrazinyl, phenyl 1-4C alkyl, naphthyl 1-4C alkyl, (both optionally substituted on the aryl ring) or piperonyl; R4 and R5 = H, 1-5C alkyl or, together with the N atom, form piperidinyl or morpholinyl, aryl and heteroaryl groups being optionally substituted by halogens, 1-4C alkyl, CF3, 1-4C alkylthio, alkoxy, alkylsulfonyl, NO2, -COOR, -CH2-COOR, or -O-CH2-COOR, and R = 1-4C alkyl.

IPC 1-7 (main, further and additional classification)

C07D 241/08; A61K 31/495; C07D 401/12; C07D 405/12

IPC 8 full level (invention and additional information)

A61K 31/495 (2006.01); A61K 31/496 (2006.01); A61P 7/02 (2006.01); A61P 43/00 (2006.01); C07D 241/08 (2006.01); C07D 401/12 (2006.01); C07D 405/12 (2006.01)

CPC (invention and additional information)

C07D 401/12 (2013.01); C07D 241/08 (2013.01); C07D 405/12 (2013.01); Y02P 20/55 (2015.11)

Citation (search report)

See references of WO 0004000A1

Designated contracting state (EPC)

AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

EPO simple patent family

FR 2781220 A1 20000121; FR 2781220 B1 20001013; AU 4629199 A 20000207; AU 752632 B2 20020926; BR 9912839 A 20010605; CA 2337849 A1 20000127; CA 2337849 C 20090317; CN 1188402 C 20050209; CN 1309648 A 20010822; EA 003511 B1 20030626; EA 200100151 A1 20010625; EP 1098888 A1 20010516; JP 2002520401 A 20020709; NZ 509166 A 20040130; US 6344456 B1 20020205; WO 0004000 A1 20000127

INPADOC legal status


2006-07-26 [18W] WITHDRAWN

- Effective date: 20060608

2002-08-07 [17Q] FIRST EXAMINATION REPORT

- Effective date: 20020620

2001-05-16 [17P] REQUEST FOR EXAMINATION FILED

- Effective date: 20010102

2001-05-16 [AK] DESIGNATED CONTRACTING STATES:

- Kind Code of Ref Document: A1

- Designated State(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

2001-05-16 [AX] REQUEST FOR EXTENSION OF THE EUROPEAN PATENT TO

- Free text: AL;LT;LV;MK;RO;SI